“…There are, however, several methods available for the estimation of the axis of rotation based on 3D landmarks, especially in the area of biomechanics (Halvorsen et al, 1999;Rancourt et al, 2000;Rivest, 2001; Gamage and Lasenby, 2002;Teu and Kim, 2006;Rivest et al, 2008;Ball and Greiner, 2012). In the statistical literature, estimation of rotation matrices has been studied in terms of spherical regression and its generalizations (Chang, 1986(Chang, , 1988(Chang, , 1989Chapman et al, 1995;Rivest, 1989Rivest, , 1998Rivest, , 2006Chang and Rivest, 2001).…”