A new method for inducing hypothermia during cardiac arrest

Zviman, Menekhem; Roguin, Ariel; Jacobs, Avrum; Rent, Kenneth C.; Lardo, Albert C.; Halperin, Henry R.

doi:10.1097/01.ccm.0000139461.46564.51

Cited by 15 publications

(7 citation statements)

References 36 publications

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“…Other cooling techniques include the infusion of IV cold fluids, which are used in preclinical settings after cardiac arrest and ROSC [ 43 ]. Another approach is an extracorporeal system with rapid cooling rates, further supplying oxygen and drugs [ 44 , 45 ]. More invasive possibilities are cold peritoneal lavages, intraventricular cerebral hypothermia, and nasal and gastric lavages [ 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model

Weuster

Mommsen

Pfeifer

et al. 2015

Mediators of Inflammation

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Background. The deterioration of hemodynamics instantly endangers the patients' life after polytrauma. As accidental hypothermia frequently occurs in polytrauma, therapeutic hypothermia still displays an ambivalent role as the impact on the cardiopulmonary function is not yet fully understood. Methods. We have previously established a porcine polytrauma model including blunt chest trauma, penetrating abdominal trauma, and hemorrhagic shock. Therapeutic hypothermia (34°C) was induced for 3 hours. We documented cardiovascular parameters and basic respiratory parameters. Pigs were euthanized after 15.5 hours. Results. Our polytrauma porcine model displayed sufficient trauma impact. Resuscitation showed adequate restoration of hemodynamics. Induced hypothermia had neither harmful nor major positive effects on the animals' hemodynamics. Though heart rate significantly decreased and mixed venous oxygen saturation significantly increased during therapeutic hypothermia. Mean arterial blood pressure, central venous pressure, pulmonary arterial pressure, and wedge pressure showed no significant differences comparing normothermic trauma and hypothermic trauma pigs during hypothermia. Conclusions. Induced hypothermia after polytrauma is feasible. No major harmful effects on hemodynamics were observed. Therapeutic hypothermia revealed hints for tissue protective impact. But the chosen length for therapeutic hypothermia was too short. Nevertheless, therapeutic hypothermia might be a useful tool for intensive care after polytrauma. Future studies should extend therapeutic hypothermia.

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Section: Discussionmentioning

confidence: 99%

Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model

Weuster

Mommsen

Pfeifer

et al. 2015

Mediators of Inflammation

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“…39,43,44 Another invasive method of inducing hypothermia, referred to as endovascular cooling, was developed in 2004 by Zviman and colleagues. 45 With this method, a balloon catheter is inserted into the femoral vein and cools the patient's blood as it circulates past an internal cooling unit. 46 Catheters are used to reduce temperatures at rates approaching 4 °C per hour.…”

Section: Cooling Methodsmentioning

confidence: 99%

Therapeutic hypothermia for out-of-hospital cardiac arrest

Lee

Asare

2010

American Journal of Health-System Pharmacy

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“…Five minutes after experimental heart arrest, the blood was withdrawn from one of the catheters, cooled externally, then returned the circulation through another catheter. The authors claimed that this method could provide a rapid induction of mild hypothermia in the setting of cardiac arrest (Zviman et al 2004). At the clinical level, a small study of patients suffering cardiac arrest, hypothermia was applied by direct cooling of the blood using a coil (Nagao et al 2000).…”

Section: Cooling Methodsmentioning

confidence: 99%

Hypothermia as a cytoprotective strategy in ischemic tissue injury

Tang¹,

Yenari²

2010

Ageing Research Reviews

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Hypothermia is a well established cytoprotectant, with remarkable and consistent effects demonstrated across multiple laboratories. At the clinical level, it has recently been shown to improve neurological outcome following cardiac arrest and neonatal hypoxia ischemia. It is increasingly being embraced by the medical community, and could be considered an effective neuroprotectant. Conditions such as brain injury, hepatic encephalopathy and cardiopulmonary bypass seem to benefit from this intervention. It's role in direct myocardial protection is also being explored. A review of the literature has demonstrated that in order to appreciate the maximum benefits of hypothermia, cooling needs to begin soon after the insult, and maintained for relatively long period periods of time. In the case of ischemic stroke, cooling should ideally be applied in conjunction with the reestablishment of cerebral perfusion. Translating this to the clinical arena can be challenging, given the technical challenges of rapidly and stably cooling patients. This review will discuss the application of hypothermia especially as it pertains to its effects neurological outcome, cooling methods, and important parameters in optimizing hypothermic protection.

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A new method for inducing hypothermia during cardiac arrest

Cited by 15 publications

References 36 publications

Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model

Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model

Therapeutic hypothermia for out-of-hospital cardiac arrest

Hypothermia as a cytoprotective strategy in ischemic tissue injury

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