A new method for rapid mapping of the retinal thickness at the posterior pole.

Zeimer, Ran; Shahidi, Mahnaz; Mori, Marek; Zou, Shazhou; Asrani, Sanjay

doi:10.1016/s0002-9394(14)70413-1

Cited by 70 publications

(98 citation statements)

References 14 publications

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“…Since Zeimer et al (14) proposed to use macular thickness as an indicator of glaucoma severity, several studies have investigated this idea using technologies to measure retinal thickness such as OCT (18)(19)(20)(21)(22)(23)(24) . Such studies were conducted based on the theory that the macular thickness might be superior to circumpapillary RNFL for quantification of axonal loss, because retinal ganglion cell bodies are 10 to 20 times the diameter of their axons and because the retinal ganglion cell layer is more than one cell thick in the macula (25) .…”

Section: Discussionmentioning

confidence: 99%

Relationship between visual field sensitivity loss and quadrantic macular thickness measured with Stratus-Optical coherence tomography in patients with chiasmal syndrome

Moura¹,

Costa-Cunha²,

Malta³

et al. 2010

Arq. Bras. Oftalmol.

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Purpose: To correlate visual field sensitivity (VFS) loss on standard automated perimetry (SAP) and quadrantic macular thickness on optical coherence tomography (OCT) in patients with permanent temporal hemianopia from chiasmal compression. Methods: Forty eyes from 40 patients with chiasmal compression and 40 healthy eyes were submitted to standard automated perimetry and Stratus-OCT scanning. Raw data of the fast macular thickness scanning protocol were exported and macular thickness measurements were recorded and averaged for each quadrant and half of the central area. The correlation between visual field sensitivity loss and optical coherence tomography measurements was tested with Pearson's correlation coefficients and with linear regression analysis. Results: A significant association was found between each macular thickness parameter and the corresponding central VF mean sensitivity. The strongest association was observed between superonasal macular thickness and the inferotemporal mean defect measured both in decibel (R=0.47; p=0.001) and in 1/Lambert (R=0.59; p<0.0001) units. Conclusion: Stratus-OCT-measured macular thickness was topographically related with visual field sensitivity loss in patients with temporal hemianopia from chiasmal compression. Such measurements could prove clinically useful in the diagnosis and follow-up of patients with chiasmal compression. ClinicalTrial.gov identifier number: NCT0039122.Keywords: Tomography, optical coherence; Perimetry; Optic atrophy; Optic chiasm; Hemianopsia; Visual fields RESUMO Objetivo: Avaliar a correlação entre o defeito de campo visual ao exame de perimetria computadorizada e a espessura macular quadrântica ao exame de tomografia de coerência óptica (OCT) em pacientes com hemianopsia temporal permanente causada por compressão quiasmática. Métodos: Quarenta olhos de 40 pacientes com compressão quiasmática e 40 olhos de 40 indivíduos controles foram submetidos aos exames de perimetria computadorizada e tomografia de coerência óptica. Dados não processados foram exportados e as medidas de espessura macular foram calculadas para cada quadrante e metade da área macular central. A correlação entre o defeito campimétrico e as medidas de espessura macular foi avaliada por coeficiente de correlação de Pearson e por análise de regressão linear. Resultados: Associação significante foi encontrada entre os parâmetros de espessura macular e seus respectivos defeitos campimétricos. A correlação mais forte foi encontrada entre o parâmetro espessura macular nasal superior e o defeito campimétrico médio temporal inferior medido em decibel (R=0,47; p=0,001) e em 1/Lambert (R=0,59; p<0,0001). Conclusão: Medidas de espessura macular avaliada através da tomografia de coerência óptica foi topograficamente relacionada ao defeito campimétrico em pacientes com hemianopsia temporal por compressão quiasmática. Estas medidas podem provar a importância clínica no diagnóstico e seguimento dos pacientes com compressão quiasmática. ClinicalTrial.gov identifier number: NCT00391...

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Section: Discussionmentioning

confidence: 99%

Relationship between visual field sensitivity loss and quadrantic macular thickness measured with Stratus-Optical coherence tomography in patients with chiasmal syndrome

Moura¹,

Costa-Cunha²,

Malta³

et al. 2010

Arq. Bras. Oftalmol.

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“…These two peaks are later detected by a computer and the difference between them is measured, using this measure to map the posterior pole and calculate its thickness. 4 Optical coherence tomography (OCT) provides high-resolution cross-sectional images of the retina permitting visualization of abnormalities in the retinal structure. It projects an infrared light of 820 nm, which produces high-resolution (axial 10 mm, transversal 20 mm) interferometry cross-sectional images of the retina.…”

Section: Introductionmentioning

confidence: 99%

Macular thickness in patients with choroidal neovascularization determined by RTA and OCT3: Comparative results

Montero¹,

Ruiz-Moreno

2004

Eye

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Aims The authors conducted a study to compare retinal thickness in patients with choroidal neovascularization (CNV) using optical coherence tomography (OCT) and retinal thickness analyser (RTA). Methods In all, 11 eyes from 11 patients with subfoveal choroidal neovascularization were examined with OCT and RTA. Results Three patients could not be explored by RTA due to lack of fixation and high myopia. The mean foveal thickness was 289.9792.1 mm with OCT and 207.7760.8 mm with RTA. The mean perifoveal thickness was 293.8746.3 mm and 200.8761.3 mm, respectively. The maximal perifoveal thickness measured by OCT was 3357104.0 mm and 316786.8 mm by RTA. Conclusion OCT and RTA are able to detect increases in retinal thickness due to the presence of CNV and of fluid extravasation. They can be used in measuring retinal thickness in patients with CNV, although measures are not comparable between both systems.

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“…New methods with which to examine the retina, such as the retinal thickness analyzer (RTA) 5 and the retinal leakage analyzer (RLA), 6 have been recently introduced. These systems are able to measure reproducibly in a clinical setting changes in the thickness of the retina and localized alterations of the blood-retinal barrier (BRB).…”

mentioning

confidence: 99%

Alterations of the Blood-Retinal Barrier and Retinal Thickness in Preclinical Retinopathy in Subjects With Type 2 Diabetes

Lobo¹

2000

Arch Ophthalmol

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A new method for rapid mapping of the retinal thickness at the posterior pole.

Cited by 70 publications

References 14 publications

Relationship between visual field sensitivity loss and quadrantic macular thickness measured with Stratus-Optical coherence tomography in patients with chiasmal syndrome

Relationship between visual field sensitivity loss and quadrantic macular thickness measured with Stratus-Optical coherence tomography in patients with chiasmal syndrome

Macular thickness in patients with choroidal neovascularization determined by RTA and OCT3: Comparative results

Alterations of the Blood-Retinal Barrier and Retinal Thickness in Preclinical Retinopathy in Subjects With Type 2 Diabetes

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