“…The possibility of having a lesion absence in the image can be presented, resulting in the consideration of patients as normal and healthy, therefore; no segmentation is required. Besides, we assessed statistically the segmentation quality of the proposed against GraphCut, Watershed, and MSA, by picking: Accuracy [37] , Sensitivity [38] , F-Measure [38] , Precision [39] , MCC (Mathew Correlation Coefficient) [38] , Dice [40] , Jaccard [40] , and Specificity [38] . By definition, higher values on these indexes imply a better quality of segmentation.…”