A new model of acute inflammation: Cobra venom factor induced paw oedema

Leyck, S.; Etschenberg, E.; Hadding, U.; Winkelmann, Johannes

doi:10.1007/bf02176411

Cited by 14 publications

(8 citation statements)

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“…while that of kappa-carrageenins is relatively low ( Table 2). The rat paw edema after iotacarrageenin is 2.5-fold weaker than the lambdacarrageenin rat paw edema [4]. Thus, there seems to be no positive or negative correlation between thrombogenic and edemogenic activity of various carrageenins.…”

Section: Effect Of Substances On Frequency and Extent Of Thrombosismentioning

confidence: 96%

Carrageenin-induced thrombosis in rats and mice: A model for testing antithrombotic substances?

1985

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Among different carrageenins, kappa-carrageenans were found to be thrombogenic, whereas lambda-carrageenins were inactive in this respect, although the latter substances exerted a stronger edemogenic activity. Kappa-carrageenin (Sigma) was the most potent thrombogen. As the consequence of thrombosis tail infarction became visible some minutes after i.v. administration, but it was delayed for about 3 hours after the i.p. route and for about 6 hours after subplantar injection. Infarction frequency as well as extent of infarction was inhibited by heparin, cyproheptadine, phentolamine and dibenamine. Other substances like aspirin and dipyridamole showed no or only weak effects. Advantages of the carrageenin-induced thrombosis model in rats and mice are: (i) simple induction in small laboratory animals, (ii) easy observation and quantification all the time without killing the animals, and (iii) possible external testing of antithrombotic agents by applying substances on the tail.

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Section: Effect Of Substances On Frequency and Extent Of Thrombosismentioning

confidence: 96%

Carrageenin-induced thrombosis in rats and mice: A model for testing antithrombotic substances?

1985

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“…This suggests that, in vivo, the cyclo-oxygenase-inhibitory activity of ebselen and/or its metabolites [18] is weak and contributes very little to the antiinflammatory action of the drug. However, in 3 h cobra venom factor (CVF)-induced paw oedema, a test originally established to test inhibitors of complement activation [19,20], ebselen proved to be a much more potent inhibitor than several NSAIDs, indometacin failing to give 50% inhibition at nontoxic doses ( Table 1). The fact that the dual cyclooxygenase/lipoxygenase inhibitors and antioxidants Inactive.…”

Section: Acute Paw Oedemasmentioning

confidence: 99%

The pharmacology of ebselen

Parnham¹,

Leyck²,

Graf³

et al. 1991

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“…Several attempts have been made to develop other inflammatory models. Among these attempts, cobra venom factor or zymosan were used to induce complementdependent inflammatory reactions in the skin (Konno & Tsurufuji, 1983), paws (Gemmel et al, 1979;Leyck et al, 1983;, and the pleural (Martins et al, 1989) or abdominal cavities of rats (Wood et al, 1988;Griffiths & Wood, 1989). To compare both models, we examined the peritonitis induced by zymosan and by carrageenin.…”

Section: Introductionmentioning

confidence: 99%

Kinins and peritoneal exudates induced by carrageenin and zymosan in rats

Damas

Bourdon

Remacle-Volon

et al. 1990

British J Pharmacology

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1 Kinins were measured by a radioimmunoassay in the inflammatory exudates induced by carrageenin or zymosan in the peritoneal cavity of normal Wistar rats and of kininogen-deficient Brown Norway rats. 2 After administration of carrageenin to normal rats, levels of immunoreactive kinins showed a single peak during the first two hours and then decreased. The presence of kinins preceded and accompanied the exudation of '25I-labelled albumin. Kinins were identified as bradykinin by chromatography. 2 Captopril, an inhibitor of kininase 2, increased the level of kinins and the volume of the exudates after carrageenin treatment. In Brown Norway rats, the volume of the exudates was small and contained little or undetectable amounts of immunoreactive kinins. 4 During zymosan-induced peritonitis, the exudates were devoid of immunoreactive kinins in both species. The volume of the exudates was larger in kininogen-deficient rats than in normal rats. 5 We conclude that in rats, the kinin system is a major factor responsible for the development of the inflammatory reactions induced by carrageenin, but is not involved in the reactions induced by zymosan.

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A new model of acute inflammation: Cobra venom factor induced paw oedema

Cited by 14 publications

References 0 publications

Carrageenin-induced thrombosis in rats and mice: A model for testing antithrombotic substances?

Carrageenin-induced thrombosis in rats and mice: A model for testing antithrombotic substances?

The pharmacology of ebselen

Kinins and peritoneal exudates induced by carrageenin and zymosan in rats

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