A new model of allergic rhinitis in rats by topical sensitization and evaluation of H1-receptor antagonists

Sugimoto, Yukihiko; Kawamoto, Etsuko; Chen, Zhong; Kamei, Chiaki

doi:10.1016/s0162-3109(00)00173-9

Cited by 46 publications

(33 citation statements)

References 22 publications

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“…In addition, an increase in PCA titer, indicating the production of antigen-specific IgE antibody, was also noted (data not shown). Almost the similar findings in rats were reported by Sugimoto et al (15), who showed that the topical instillation of antigen resulted in a significant increase of sneezing and nasal rubbing as well as PCA titer in sensitized rats.…”

Section: Discussionsupporting

confidence: 85%

Participation of Histamine H3 Receptors in Experimental Allergic Rhinitis of Mice

et al. 2008

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Abstract. The present study was performed to study the participation of histamine H 3 receptors in nasal symptoms using Sch 50971, a potent and selective agonist of the H 3 receptor. Repeated topical application of antigen caused an increase in sneezing and nasal rubbing in sensitized mice. Oral administration of Sch 50971 and imetit, specific H 3 -receptor agonists, resulted in an inhibition of nasal symptoms induced by an antigen similar to an H 1 -receptor antagonist, cetirizine. Furthermore, simultaneous use of H 3 -receptor agonists, Sch 50971 or imetit, and an H 1 -receptor antagonist, cetirizine, caused a significant inhibitory effect on nasal symptoms at doses that showed no effect when used separately. The number of eosinophils in the nasal mucosa of mice sensitized with antigen was significantly decreased by cetirizine; however, Sch 50971 and imetit had no effect on eosinophil infiltration. These results clearly indicate that H 3 receptors are involved in the etiology of nasal allergy, and the stimulation of H 3 receptors may be useful as a novel therapeutic approach in nasal allergy.

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Section: Discussionsupporting

confidence: 85%

Participation of Histamine H3 Receptors in Experimental Allergic Rhinitis of Mice

et al. 2008

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“…[18][19][20][21] As a matter of course, there are some findings that histamine H 1 -receptor antagonists inhibited the symptoms of sneezing and nasal rubbing of allergic rhinitis model in mice and rats. 22,23) Moreover, other investigators have shown that the suppression of antigen-specific IgE production inhibited the nasal symptoms of an allergic rhinitis model. 24) Because, it is well known that IgE is one of the risk factors for the allergic rhinitis.…”

Section: Discussionmentioning

confidence: 98%

Effects of Lactobacillus acidophilus Strain L-55 on Experimental Allergic Rhinitis in BALB/c Mice

Sunada¹,

Nakamura²,

Kamei

2007

Biological & Pharmaceutical Bulletin

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We investigated the effect of Lactobacillus acidophilus strain L-55 isolated from infant feces on experimental allergic rhinitis in BALB/c mice. The heat-treated cells of strain L-55 were orally administrated for 4 consecutive weeks to mice sensitized by ovalbumin (OVA), and nasal symptoms (sneezing and nasal rubbing) induced by OVA challenge were evaluated. Strain L-55 at doses of 1 and 10 mg cells/mouse significantly inhibited nasal symptoms by repeated administration over a period of 2 weeks. Furthermore, we measured the level of OVA-specific IgE titers in the serum by passive cutaneous anaphylaxis (PCA) reaction. PCA titers in the sera from mice administrated strain L-55 were significantly lowered compared with the control. These results suggest that oral administration of strain L-55 may be useful for alleviating the nasal symptoms of allergic rhinitis.

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“…18) In our previous study, we observed that H 1 receptor antagonists potently depressed antigen antibody-induced sneezing and nasal rubbing in rats. 19) In order to clarify the mechanism of action of Pleurotus pulmonarius, we studied the effect of Pleurotus pulmonarius on sneezing and nasal rubbing induced by histamine in non-sensitized mice. Pleurotus pulmonarius caused no inhibition of the sneezing and nasal rubbing induced by histamine even at a high dose of 500 mg/kg (date not shown); therefore, it can be concluded that the inhibition of sneezing and nasal rubbing induced by Pleurotus pulmonarius is not ascribed to an H 1 -antagonistic effect.…”

Section: Discussionmentioning

confidence: 99%

Effect of Usuhiratake (Pleurotus pulmonarius) on Sneezing and Nasal Rubbing in BALB/c Mice

Yatsuzuka

Nakano

Jiang

et al. 2007

Biological & Pharmaceutical Bulletin

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The anti-rhinitis properties of Pleurotus pulmonarius were investigated in BALB/c mice. A single administration of Pleurotus Pulmonarius caused no significant effect on antigen-induced nasal rubbing and sneezing at a dose of 500 mg/kg, but a significant inhibition was observed after 2 weeks of repeated treatment at this dose, and at a dose of 200 mg/kg, it also caused a significant inhibition after repeated administration for 4 weeks. Pleurotus pulmonarius showed no significant inhibitory effect on the production of IgE. In addition, Pleurotus pulmonarius caused no inhibition of histamine-induced nasal rubbing and sneezing at a dose of 500 mg/kg, but in vitro study, it inhibited histamine release from rat mast cells induced by compound 48/80 at the soluble supernatant solution of 30 and 100 m mg/ml of Pleurotus pulmonarius suspended in PBS. These results demonstrated that Pleurotus pulmonarius may be effective in the relief of symptoms of allergic rhinitis through inhibition of histamine release.

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A new model of allergic rhinitis in rats by topical sensitization and evaluation of H1-receptor antagonists

Cited by 46 publications

References 22 publications

Participation of Histamine H3 Receptors in Experimental Allergic Rhinitis of Mice

Participation of Histamine H3 Receptors in Experimental Allergic Rhinitis of Mice

Effects of Lactobacillus acidophilus Strain L-55 on Experimental Allergic Rhinitis in BALB/c Mice

Effect of Usuhiratake (Pleurotus pulmonarius) on Sneezing and Nasal Rubbing in BALB/c Mice

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