Effect of Usuhiratake (Pleurotus pulmonarius) on Sneezing and Nasal Rubbing in BALB/c Mice

Abstract

The anti-rhinitis properties of Pleurotus pulmonarius were investigated in BALB/c mice. A single administration of Pleurotus Pulmonarius caused no significant effect on antigen-induced nasal rubbing and sneezing at a dose of 500 mg/kg, but a significant inhibition was observed after 2 weeks of repeated treatment at this dose, and at a dose of 200 mg/kg, it also caused a significant inhibition after repeated administration for 4 weeks. Pleurotus pulmonarius showed no significant inhibitory effect on the production of IgE. In addition, Pleurotus pulmonarius caused no inhibition of histamine-induced nasal rubbing and sneezing at a dose of 500 mg/kg, but in vitro study, it inhibited histamine release from rat mast cells induced by compound 48/80 at the soluble supernatant solution of 30 and 100 m mg/ml of Pleurotus pulmonarius suspended in PBS. These results demonstrated that Pleurotus pulmonarius may be effective in the relief of symptoms of allergic rhinitis through inhibition of histamine release.

Establishment and characterization of a novel murine model for pollen allergy

“…immunization of the antigen with an alum adjuvant and then subsequent antigen challenges to the nose to obtain a strong and stable allergic status. 11,12) We did not find any apparent IgE induction in our present study when BALB/c mice were treated with the OVA solution, the reason for their different result from ours being unknown. Considering that the IgE level was expressed as units in their report, a small change in IgE concentration that we could not detect might have occurred in their study.…”

“…Yatsuzuka et al have also reported the anti-allergic properties of Usuhiratake (Pleurotus pulmonarius) by evaluating the inhibition of sneezing and nasal rubbing induced by the antigen in BALB/c mice that had been intraperitoneally sensitized with OVA, alum, and B. pertussis. 12) According to these reports, the effects of anti-allergic foods on such symptoms as sneezing could be evaluated using this model, although a difference in the induction mechanism of allergy might influence the mechanism causing the symptoms, resulting in a difference in the efficacy of anti-allergic foods on the symptoms. This model would therefore not be appropriate for evaluating the comprehensive effects of anti-allergic foods on pollen allergy, and it is necessary to use a more natural allergic model to evaluate anti-allergic foods.…”

Cultivation of oyster mushrooms (Pleurotus sp.) using organic waste: an example with Pleurotus pulmonarius (Fr.) Quel.

“…P. pulmonarius was first found by an scientist in India and then brought to China, where its cultivation began. Recently, there has been an increase in the importance of its cultivation in Japan (Yatsuzuka et al 2007). P. pulmonarius is especially popular in Western Europe, North America and New Zealand (Baggio et al 2010).…”

Antinociception of β-d-glucan from Pleurotus pulmonarius is possibly related to protein kinase C inhibition

“…Quel., an edible mushroom used in Chinese cuisine, revealed it contains several polysaccharides, alongside a high amount of proteins, essential amino acids and vitamins, but no lipids or starch [1,2]. Among these polysaccharides are xyloglucan, mannogalactan and ␤-d-glucan [3][4][5].…”