A New Neuroimplantable Device: The Tulgar Implant. Initial Results of Animal Testing

Kalkan, Erdal; Arican, Mustafa; Kalkan, Sevda; Erayman, İbrahim; Erol, Atila; Tulgar, Ayse Oya; Tulgar, Metin

doi:10.1111/j.1525-1403.2005.00033.x

Cited by 1 publication

(2 citation statements)

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“…Tulgar implants were used after approval by the Ethical Committee of the Ministry of Health of the Republic of Turkey. Technical specifications of the implants are explained elsewhere [ 17 ]. The main goal of the Tulgar neuroimplant, which is a semi-implantable system, is that the implanted part is completely passive, containing neither a battery nor any active electronic components.…”

Section: Methodsmentioning

confidence: 99%

“…Whilst comprehensively considering scientific aspects of stimulation, the recently developed Tulgar neuroimplant system has made possible the opportunity to try parameters which are consistent with the nature of the human body [ 16 – 18 ]. This study is one of seven steps of a long-term research program related to Tulgar implants: (1) the development of a prototype model; (2) bench testing with the prototype; (3) laboratory tests; (4) environmental safety tests; (5) development of clinical model that is implantable in the living tissue; (6) animal testing [ 17 ]; and (7) pilot implantation in humans. The data presented in the present study covers the human implantation phase.…”

Section: Introductionmentioning

confidence: 99%

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The Human Body’s Own Language to be Considered for Safe and Effective Neurostimulation

Tulgar¹,

Bilgin²,

Yıldırım³

2012

Neurol Ther

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IntroductionThe general objective of this study was to provide an improved software for safer and more effective neurostimulation therapy.Materials and MethodsTulgar implants, employing combined modulation of stimulation synchronized with heart rate, breathing frequency, and position of the patient (HBP), were applied as vagus nerve stimulation (VNS) for the management of refractory epilepsy in 105 patients who were followed up for 1 year.ResultsFifty-nine out of 105 (56.19%) patients were seizure free, 34 (32.38%) patients had partial improvement in quality of life with a decrease in intensity and frequency of the seizures, and 12 (11.43%) patients did not respond to stimulation.DiscussionOther similar studies, undertaken with non-Tulgar equipment, reported a 10% full recovery, 60% partial improvement in quality of life, and 30% zero response. Comparisons of these results reveal an approximate fivefold increase in seizure freedom, and threefold decrease in the number of nonresponsive patients.ConclusionsThe findings of the present study imply that HBP-modulated mode of stimulation could be safer and more effective in neurostimulation, at least in VNS.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%