The driving device of the main steam and feed water isolation valves is one of the most important electromechanical equipment in nuclear power plants, and its motion performances are related to the safety of nuclear power plants. This article proposes an optimization methodology to research the motion performances. In the methodology, inputs are the motion performance indexes and the major influencing parameters with no need for complex mathematical models of the electromechanical equipment; the co-simulation model or the prototype are adopted to illustrate the influence rules of major parameters on the motion performance indexes; objective functions for optimization, which combine motion performances with weight factors, can reveal the influence rule curves. Then based on the methodology, motion performances of the equipment are analyzed and the key indexes are selected. Besides, the maximum pressure of the driving device is chosen as the major parameter and a dimensionless objective function synthesizing the motion performance indexes is proposed. Finally, the influence rule curve where the dimensionless function varies with the maximum pressure is obtained by the co-simulation and the experimental study on the prototype verifies the results, which provides references for the further research and development in the engineering application. For other electromechanical equipment, the method is an efficient tool to design, verify, and optimize the performances.