A New Perspective on Fish Oil: The Prevention of Alcoholic Liver Disease

Yang, Suh‐Ching

doi:10.5650/jos.ess21216

Cited by 7 publications

(4 citation statements)

References 60 publications

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“…In our experimental paradigm, DHA accounted for approximately 2.5% of the total energy, which is in the range used in human clinical trials ( 76 ). We demonstrate here that DHA enrichment improved the metabolic status of male rats, as previously reported ( 42 , 77 ), as it normalized several metabolic markers that were increased by the HF diet. Moreover, it also prevented hypothalamic inflammation as all HF diet-induced increases of inflammatory markers were normalized under DHA.…”

Section: Discussionsupporting

confidence: 88%

Disruption of Pituitary Gonadotrope Activity in Male Rats After Short- or Long-Term High-Fat Diets Is Not Associated With Pituitary Inflammation

et al. 2022

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Overnutrition is associated with the activation of inflammatory pathways in metabolically linked organs and an early hypothalamic inflammation is now known to disrupt the central control of metabolic function. Because we demonstrated that fatty acids (FA) target the pituitary and affect gonadotropin synthesis, we asked whether overnutrition induces pituitary inflammation that may contribute to obesity-associated disorders in the control of reproduction. We analyzed pituitary inflammation and hypothalamic-pituitary-testicular axis in male rats fed a short- (4 weeks) or long-term (20 weeks) high-fat diet. The effect of diet enrichment with the ω3 polyunsaturated FA, DHA, was also analyzed. After only 4 weeks and before weight gain of rats, high-fat diet caused a significant decrease in pituitary gonadotropin and hypothalamic GnRH transcript levels despite unchanged testosterone and inhibin B levels. Contrasting with the hypothalamus, there was no concomitant increases in gene expression of pituitary inflammatory mediators and even a reduction of prototypical cytokines such as interleukin-1β and TNF-α. No inflammation was still detected in the pituitary after 20 weeks although gonadotropin transcripts and circulating levels were still altered. Gonadotropins were the only pituitary hormones remaining affected at this stage of the regimen, underlying a differential susceptibility of pituitary lineages to metabolic disorders. DHA enrichment of the diet did not prevent alterations of gonadotrope activity due to either a long- or a short-term high-fat diet although it blocked early hypothalamic inflammation and attenuated several metabolic effects. Taken together, our findings suggest that high-fat diet-induced defects in gonadotrope activity in male rats occurred despite a lack of pituitary inflammation.

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Section: Discussionsupporting

confidence: 88%

Disruption of Pituitary Gonadotrope Activity in Male Rats After Short- or Long-Term High-Fat Diets Is Not Associated With Pituitary Inflammation

et al. 2022

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“…Mounting evidence points to dietary lipids that can potentially serve as inexpensive interventions for the prevention and treatment of alcohol-induced liver Food & Function Paper dysfunction. 28,29 However, most studies on the above dietary lipids are limited to SFAs and PUFAs. Therefore, this study was conducted to clarify the influence of a MUFA enriched diet, represented by OO, on AFLD in the experimental C57BL/6J mice and explore its underlying mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Monounsaturated fatty acid-enriched olive oil exacerbates chronic alcohol-induced hepatic steatosis and liver injury in C57BL/6J mice

et al. 2023

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“…Furthermore, dietary fatty acids from deep-sea fish such as salmon, cod, sardines, and Antarctic krill organisms have attracted much attention for their human health benefits [28,35,[43][44][45][46][47]. Deep-sea fish oils are rich in unsaturated fatty acids, including the Omega-3 family of fatty acids, represented by EPA and DHA, which have received much attention because of their nutritional health functions [48]. Dietary Omega-3 polyunsaturated fatty acids in deep-sea fish oil supplementation improves hepatic lipid metabolism by regulating bile acid metabolism [49].…”

Section: Marine-derived Unsaturated Fatty Acidsmentioning

confidence: 99%

Advances in Research on Marine-Derived Lipid-Lowering Active Substances and Their Molecular Mechanisms

Liu,

Chen,

Chen

et al. 2023

Nutrients

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Hyperlipidemia (HLP) is a metabolic disorder caused by abnormal lipid metabolism. Recently, the prevalence of HLP caused by poor dietary habits in the population has been increasing year by year. In addition, lipid-lowering drugs currently in clinical use have shown significant improvement in blood lipid levels, but are accompanied by certain side effects. However, bioactive marine substances have been shown to possess a variety of physiological activities such as hypoglycemic, antioxidant, antithrombotic and effects on blood pressure. Therefore, the hypolipidemic efficacy of marine bioactive substances with complex and diverse structures has also attracted attention. This paper focuses on the therapeutic role of marine-derived polysaccharides, unsaturated fatty acids, and bioactive peptides in HLP, and briefly discusses the main mechanisms by which these substances exert their hypolipidemic activity in vivo.

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A New Perspective on Fish Oil: The Prevention of Alcoholic Liver Disease

Cited by 7 publications

References 60 publications

Disruption of Pituitary Gonadotrope Activity in Male Rats After Short- or Long-Term High-Fat Diets Is Not Associated With Pituitary Inflammation

Disruption of Pituitary Gonadotrope Activity in Male Rats After Short- or Long-Term High-Fat Diets Is Not Associated With Pituitary Inflammation

Monounsaturated fatty acid-enriched olive oil exacerbates chronic alcohol-induced hepatic steatosis and liver injury in C57BL/6J mice

Advances in Research on Marine-Derived Lipid-Lowering Active Substances and Their Molecular Mechanisms

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