A new plant growth regulator of microbial origin

Voblikova, V. D.; Kobrina, N. S.; Gerasimova, Natalia; Pavlova, Z. N.; Dem'yanova, G. F.; Murygina, V. P.; Volosova, L. I.; Muromtsev, G. S.

doi:10.1007/bf00574213

Cited by 6 publications

(8 citation statements)

References 3 publications

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“…Studies of the factors affecting the germination and growth of plants have shown that the 1-ketooctyl derivative of alkylresorcinolic acid 93 , at a concentration of 3 μg/mL inhibits germination of seeds by 50%. As this compound was isolated from a fungal plant pathogen, the authors suggested the participation of resorcinolic lipids in infections and in the killing of organisms infected by fungi . The supposition that the occurrence of resorcinolic lipids in cereal grains might be responsible for the decreased growth of animals fed with them was raised for the first time in Wieringa's work .…”

Section: B Resorcinolic Lipids As Growth Regulators and In Host−paras...mentioning

confidence: 99%

“…As this compound was isolated from a fungal plant pathogen, the authors suggested the participation of resorcinolic lipids in infections and in the killing of organisms infected by fungi. 97 The supposition that the occurrence of resorcinolic lipids in cereal grains might be responsible for the decreased growth of animals fed with them was raised for the first time in Wieringa's work. 11 Later results, however, showed that the main cause of a retardation in the animal growth rate is more related to an antifeedant effect, namely alkylresorcinol-induced decrease of the appetite.…”

Section: A Antimicrobial Antiparasitic and Cytotoxic Activitymentioning

confidence: 99%

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Resorcinolic Lipids, the Natural Non-isoprenoid Phenolic Amphiphiles and Their Biological Activity

1998

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Section: B Resorcinolic Lipids As Growth Regulators and In Host−paras...mentioning

confidence: 99%

Section: A Antimicrobial Antiparasitic and Cytotoxic Activitymentioning

confidence: 99%

Resorcinolic Lipids, the Natural Non-isoprenoid Phenolic Amphiphiles and Their Biological Activity

1998

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“…3,5-Dimethoxyphenylacetic acid (6) Compound 8 was subsequently demethylated using AlCl 3 in toluene under reflux, to give cytosporone A (1) with a good yield (90%). Cytosporone A tautomerism, reported by Voblikova et al, 5 was not detected in the 1 H NMR spectra using deuterated methanol as the solvent. Cytosporone B (2) was obtained in a quantitative yield from 1 after esterification in acid medium with ethanol.…”

Section: Synthesismentioning

confidence: 69%

“…), regulates seed germination factors at low concentrations, in addition to having herbicidal potential. 5 Inhibition of plant growth and development by compounds released in the environment by other plants or microorganisms is known as allelopathy. The term applies both to beneficial or detrimental interactions, involving either direct or indirect mechanisms.…”

Section: Staphylococcus Aureus Enterococcus Faecalis Andmentioning

confidence: 99%

Total synthesis and allelopathic activity of cytosporones A-C

Zamberlam¹,

Meza²,

Leite³

et al. 2012

J. Braz. Chem. Soc.

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A busca por herbicidas eficientes e ambientalmente corretos tem sido foco de numerosos estudos sobre a síntese de compostos isolados de fontes naturais. Citosporonas, as quais são lipídeos fenólicos isolados de fungos, apresentam notáveis propriedades biológicas. Este artigo relata a preparação das citosporonas A, B e C, através de uma rota sintética curta e com excelentes rendimentos. Os compostos sintetizados foram avaliados quanto às suas atividades alelopáticas em sementes de alface (Lactuca sativa L). Citosporona A e seu precursor metilado mostraram notável atividade alelopática, inibindo a germinação de sementes e crescimento das plântulas.The search for efficient, environmentally friendly herbicides has been the focus of numerous studies on the organic synthesis of compounds isolated from natural sources. Cytosporones, which are phenolic lipids isolated from fungi, exhibit noteworthy biological properties. This paper reports the preparation of cytosporones A-C from the same starting material through a short synthetic route, with good yields. All compounds were tested for allelopathic activity on lettuce (Lactuca sativa L) seeds. Cytosporone A and its methylated precursor showed remarkable allelopathic activity, inhibiting seed germination and plantule growth.

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“…At a dosage of 3 μg/mL, cytosporone A suppresses seed germination by 50%. 17 As aforementioned, cytosporone B acts as a natural agonist ligand for the nuclear orphan receptor Nur77 in eukaryotic cells, which controls apoptosis in cancer cells and sugar metabolism in mammals, establishing this resorcinolic lipid as a potent and selective cytotoxic agent. 7 Clardy et al also report bactericidal action of cytosporones D and E against Staphylococcus aureus, Enterococcus faecalis, and Escherichia coli, as well as fungicidal activity against Candida albicans.…”

Section: ■ Introductionmentioning

confidence: 97%

Chemotherapeutic Mechanism of Action of the Synthetic Resorcinolic Methyl 3,5-dimethoxy-2-octanoylbenzoate

Correa,

das Neves,

Oliveira

et al. 2024

Chem. Res. Toxicol.

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Resorcinolic lipids are described as potential examples of selective chemotherapeutic adjuvants that can enhance the effects of cyclophosphamide (CYC) while promoting cell death without causing DNA damage. Therefore, the current study attempted to describe how the resorcinolic lipid methyl 3,5-dimethoxy-2-octanoylbenzoate (AMS35BB) interacted with DNA (DNA docking) and how this compound affected genetic toxicology models and other biological characteristics when combined with CYC. We observed that AMS35BB, used alone (7.5 and 10 mg/kg), increases the frequency of genomic damage (comet assay) but not chromosomal damage (micronuclei assay), lowers phagocytosis, and promotes cell death in Swiss male mice. When used in association with CYC, AMS35BB can reduce the risk of genomic damage by up to 33.8% as well as chromosomal damage, splenic phagocytosis, cell death, and lymphocyte frequency. Molecular docking showed that AMS35BB had a higher affinity than the active metabolite of CYC for binding to the DNA double helix major groove. As a result, AMS35BB has the potential to be both an adjuvant when used in association with CYC and a therapeutic candidate for the development of a selective chemotherapeutic drug.

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A new plant growth regulator of microbial origin

Cited by 6 publications

References 3 publications

Resorcinolic Lipids, the Natural Non-isoprenoid Phenolic Amphiphiles and Their Biological Activity

Resorcinolic Lipids, the Natural Non-isoprenoid Phenolic Amphiphiles and Their Biological Activity

Total synthesis and allelopathic activity of cytosporones A-C

Chemotherapeutic Mechanism of Action of the Synthetic Resorcinolic Methyl 3,5-dimethoxy-2-octanoylbenzoate

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