A new potent antifungal agent from Actinoplanes sp

Chu, Min; Truumees, Imbi; Mierzwa, Ronald; Terracciano, Joseph; Patel, Mahesh; Das, Pradip R.; Puar, Mohindar S.; Chan, T. M.

doi:10.1016/s0040-4039(98)01696-7

Cited by 23 publications

(22 citation statements)

References 3 publications

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“…kibdelones X X X citreamicins X X [12,17] kigamicins X X [15,16] simaomicins X X [14,18] albofungins X X X [8,19] actinoplanones X X X [10,11] Sch54445/56036/42137 X [20][21][22] cervinomycins X [23,24] …”

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confidence: 99%

Kibdelones: Novel Anticancer Polyketides from a Rare Australian Actinomycete

Ratnayake

Lacey²,

Tennant³

et al. 2007

Chemistry A European J

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The kibdelones are a novel family of bioactive heterocyclic polyketides produced by a rare soil actinomycete, Kibdelosporangium sp. (MST-108465). Complete relative stereostructures were assigned to kibdelones A-C (1-3), kibdelone B rhamnoside (5), 13-oxokibdelone A (7), and 25-methoxy-24-oxokibdelone C (8) on the basis of detailed spectroscopic analysis and chemical interconversion, as well as mechanistic and biosynthetic considerations. Under mild conditions, kibdelones B (2) and C (3) undergo a facile equilibration to kibdelones A-C (1-3), while kibdelone B rhamnoside (5) equilibrates to a mixture of kibdelone A-C rhamnosides (4-6). A plausible mechanism for this equilibration is proposed and involves air oxidation, quinone/hydroquinone redox transformations, and a choreographed sequence of keto/enol tautomerizations that aromatize ring C via a quinone methide intermediate. Kibdelones exhibit potent and selective cytotoxicity against a panel of human tumor cell lines and display significant antibacterial and nematocidal activity.

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confidence: 99%

Kibdelones: Novel Anticancer Polyketides from a Rare Australian Actinomycete

Ratnayake

Lacey²,

Tennant³

et al. 2007

Chemistry A European J

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“…The rise in prevalence of fungal infections and drug resistance has exacerbated the need for new antifungal agents. The xanthone compound is present in many natural products, including some compounds that have activity against pathogenic fungi (21)(22)(23)(24). The pericarp of mangosteen is a concentrated source of xanthones.…”

Section: Discussionmentioning

confidence: 99%

Antifungal activity of alpha-mangostin against Candida albicans

2009

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This study was conducted to examine the activity of alpha-mangostin against Candida albicans, the most important microorganism implicated in oral candidiasis. Its activity was compared to Clotrimazole and Nystatin. Results showed that alphamangostin was effective against C. albicans, the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 1,000 and 2,000 µg/ml, respectively. The C. albicans killing activity of alpha-mangostin was more effective than Clotrimazole and Nystatin. The cytotoxicity of alphamangostin was determined and it was found that alphamangostin at 4,000 µg/ml was not toxic to human gingival fibroblast for 480 min. The strong antifungal activity and low toxicity of alpha-mangostin make it a promising agent for treatment of oral candidiasis. (J Oral Sci 51, [401][402][403][404][405][406] 2009)

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“…Furthermore, Actinoplanes spp. are a group of actinobacteria known for producing pharmaceutically important compounds, such as the antimicrobial teicoplanin ( 6 , 7 ) and anticancer ( 8 ) and antidiabetic drugs ( 9 ), emerging as an important genus to search for novel specialized metabolites by genome mining ( 9 , 10 ).…”

Section: Genome Announcementmentioning

confidence: 99%