2010
DOI: 10.1532/hsf98.20101071
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A New Practical Alternative for the Control of Sternal Bleeding during Cardiac Surgery: Ankaferd Blood Stopper

Abstract: The control of sternal bleeding during cardiac surgery can sometimes be a challenging and time-consuming problem for surgeons. Several alternatives for the control of sternal bleeding are on the market. Bone wax is a well-known alternative used by many cardiac surgeons for the control of bleeding. It is effective and cheap; however, it inhibits ossification of the sternum and can cause infections and sternal wound healing problems after cardiac surgery. Consequently, control of sternal bleeding without the use… Show more

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Cited by 21 publications
(17 citation statements)
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“…Besides its hemostatic activity, it possesses antiinflammatory actions, antimicrobial activity, antithrombin, antiplatelet, wound healing, and antioxidant characteristics, and antineoplastic properties in vitro, and it does not exhibit any side effects (1,3,5,18,19).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Besides its hemostatic activity, it possesses antiinflammatory actions, antimicrobial activity, antithrombin, antiplatelet, wound healing, and antioxidant characteristics, and antineoplastic properties in vitro, and it does not exhibit any side effects (1,3,5,18,19).…”
Section: Discussionmentioning
confidence: 99%
“…Hemostatic agents such as bone wax, Surgicel, Ostene, fibrin glue, and Ankaferd Blood Stopper (ABS) are frequently used in medicinal and dental surgery to control bleeding at diverse body sites (1,2). From these, ABS, an herbal extract used as a hemostatic agent, is a medicinal remedy for clinical management of surgery bleedings as well as immediate cessation of bleeding of external injuries based on upcoming clinical trials (3-5; www.ankaferd.…”
Section: Introductionmentioning
confidence: 99%
“…Three ABS phase III studies [4,10,12] on vascular port insertion bleeding, anterior epistaxis, and post-tonsillectomy hemorrhage have led to its approval as a hemostatic agent in Turkey. Use of ABS to control bleeding in gastrointestinal disorders [8,[24][25][26][27] and mediastinal bleeding [5,17] shed further light on its hemostatic efficacy. As such, the anti-hemorrhagic efficacy and safety of ABS was determined based on a wide variety of findings designed in different ways of clinical and experimental studies ABS has the diverse dynamic reversible actions of an EPCR and PAI-1 inside vascular endothelial cells in an HUVEC model.…”
Section: Discussionmentioning
confidence: 99%
“…As there are some anecdotal reports on the use of ABS in in different surgical interventions [17][18][19][20][21], elucidation of the surgical and histopathological effects of ABS will inform future research on this novel hemostatic agent. …”
Section: Introductionmentioning
confidence: 99%
“…В экспериментах разными авторами было показано, что костный воск замедляет регенерацию костной ткани, что препятствует заживлению грудины [20,44] и повыша-ет риск возникновения стернальной инфекции [31,39]. По данным B. Sudmann и соавт.…”
Section: методы борьбы с локальным кровотечением и их роль в возникноunclassified