A New Presentation of Neonatal Lupus: 5 Cases of Isolated Mild Endocardial Fibroelastosis Associated with Maternal Anti-SSA/Ro and Anti-SSB/La Antibodies

Abstract

Middle-term prognosis of isolated autoantibody-associated EFE may be better than previously reported, although the longterm prognosis remains unknown. We hypothesize that a fetal insult can lead to DCM.

Pregnancy implications for systemic lupus erythematosus and the antiphospholipid syndrome

“…Other life-threatening cardiopathies have been described less frequently, like endocardial fibroelastosis and dilated cardiomyopathy [31]. Cardiac NL is less common than other NL manifestations, affecting approximately 2% of exposed offspring [32].…”

Description of 214 cases of autoimmune congenital heart block: Results of the French neonatal lupus syndrome

“…Cardiac manifestations include congenital heart block (CHB), endocardial fibroelastosis (EFE) and dilated cardiomyopathy (DCM) [1][2][3][4][5][6][7][8][9]. CHB is defined by atrio-ventricular block occurring in utero or in the neonatal period (b 28 days of life) [9].…”

Resolved Mystery of Difficult Neonatal Resuscitation

“…Non cardiac manifestations of NLE usually resolve within few months coincident within the clearance of the maternal antibodies from child's circulation. NLE may cause isolated CHB or associated with endocardial fibroelastosis, long QT syndrome and cardiomyopathy 6 . Fetal heart rate is an important indicator of the prognosis of the disease during the neonatal period.…”