A new protocol for a challenge test to assess the efficacy of live anticoccidial vaccines for chickens

Williams, R. B.; Catchpole, J.

doi:10.1016/s0264-410x(99)00387-4

Cited by 53 publications

(33 citation statements)

References 14 publications

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“…Cobb broilers were used in the present studies, while Ross broilers were used in the British trials, with potentially different effects on susceptibility to coccidiosis or on immune responses to the vaccine (see Williams & Catchpole, 2000). As male and female birds were reared separately in the Italian trials, rather than all males or as-hatched, there was an opportunity to observe whether there were any sex-specific differences between responses to the different anticoccidial treatments.…”

Section: Introductionmentioning

confidence: 99%

Comparison of an attenuated anticoccidial vaccine and an anticoccidial drug programme in commercial broiler chickens in Italy

Williams¹,

Gobbi²

2002

Avian Pathology

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A live attenuated anticoccidial vaccine (Paracox) was compared with a nicarbazin-monensin anticoccidial drug shuttle programme in three crops of Italian broilers, comprising a total of 290 405 chickens. All birds received the antibiotic growth promoter avilamycin. No coccidiosis was evident during the trials, but the occurrence of oocysts in the litter demonstrated that a natural challenge was present. Vaccinated birds consistently performed at least as well as those treated with the anticoccidial drug shuttle. The final mean weights of vaccinated birds were significantly greater (P < 0.001) than those of birds treated with anticoccidial drugs, both for females at 36/37 days and males at 56 days. Feed conversion ratios, total mortality including culls, the proportion of rejects at the processing plant, and the moisture content of the litter were not significantly different between the two control methods. Growth curves showed that there was no post-vaccinal growth check in the vaccinated birds and no intolerance of the anticoccidial drug treatment. There was no overall seasonal effect, regardless of treatment, on the performance of the three crops reared from November 1997 to July 1998. These findings suggest that the use of this vaccine is likely to enable the replacement of anticoccidial drug shuttle programmes in broilers reared under conditions similar to those used in these Italian flocks.

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Section: Introductionmentioning

confidence: 99%

Comparison of an attenuated anticoccidial vaccine and an anticoccidial drug programme in commercial broiler chickens in Italy

Williams¹,

Gobbi²

2002

Avian Pathology

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“…Another secondary criterion used in these polyvalent vaccine evaluations is the feed conversion ratio. Such experimental designs avoid the determination of the oocyst production and lesion score, following the controlled challenge with the virulent strains of Eimeria (Williams & Catchpole 2000).…”

Section: Attenuated Vaccinesmentioning

confidence: 99%

A Review of Approaches Targeting the Replacement of Coccidiostat Application in Poultry Production

Barbour

Ayyash

Iyer

et al. 2015

Rev. Bras. Cienc. Avic.

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The classical and the most commonly used approach for the prevention of coccidiosis in chickens is the incorporation of synthetic coccidiostats into their feed during the first weeks of their life. This approach has been challenged by consumers, objecting against residual antimicrobials and drug resistant microorganisms that may contaminate poultry products. Moreover, the coccidiostat application approach has been challenged in the last decade by the emerging regulations in the developed world, targeting the cessation of such a practice. The pressures from the consumers as well as from regulation agencies resulted in a great need for alternative methods to reduce, or completely replace the use of coccidiostats in modern chicken production. This replacement requires seeking for safer products that do not have any negative impact on the consumer's health. Such products are very much in demand, especially in organic poultry farming. The purpose of this review is to present approaches for the replacement of coccidiostat application in chickens through improvements in poultry house management, research in vaccine developments, and application of holistic natural products for the prevention of the economic losses resulting from coccidiosis.

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“…Traditionally, reduced lesion scores and oocyst shedding from challenged, vaccinated birds compared with unvaccinated control birds challenged similarly have been used as measures of protection against coccidiosis. 57 In addition, the severity of lesion scores has been correlated with the functional efficacy of vaccines. 57 In the case of vaccinated birds, lesions may appear because of challenge but may also be associated with pathophysiological changes and with the development of protective immunity.…”

Section: Conventional Vaccines: What Is Protection?mentioning

confidence: 99%

“…57 In addition, the severity of lesion scores has been correlated with the functional efficacy of vaccines. 57 In the case of vaccinated birds, lesions may appear because of challenge but may also be associated with pathophysiological changes and with the development of protective immunity. 58 This can be confounding, and therefore disrupt the ability to differentiate between actual lesions and a successful host immune response.…”

Section: Conventional Vaccines: What Is Protection?mentioning

confidence: 99%

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Coccidiosis: recent advancements in the immunobiology of Eimeria species, preventive measures, and the importance of vaccination as a control tool against these Apicomplexan parasites

Shivaramaiah¹,

Barta²,

Hernández-Velasco³

et al. 2014

VMRR

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Coccidiosis, caused by parasites of the genus Eimeria, is probably the most expensive parasitic disease of poultry. Species of Eimeria are ubiquitous where poultry are raised and are known to cause drastic reductions in performance and induce mortality, thereby affecting the overall health status of poultry. Chemotherapy has been the predominant form of disease control for many years, even though vaccination is steadily gaining importance as a feasible control method. The objective of this review is to highlight recent advancements in understanding the role of host immunity against coccidiosis. In addition, pros and cons associated with chemotherapy and the role of vaccination as an increasingly popular disease control method are discussed. Finally, the role played by recombinant vaccines as a potential vaccination tool is highlighted. With interest growing rapidly in understanding host-parasite biology, recent developments in designing recombinant vaccines and potential epitopes that have shown promise are mentioned.

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A new protocol for a challenge test to assess the efficacy of live anticoccidial vaccines for chickens

Cited by 53 publications

References 14 publications

Comparison of an attenuated anticoccidial vaccine and an anticoccidial drug programme in commercial broiler chickens in Italy

Comparison of an attenuated anticoccidial vaccine and an anticoccidial drug programme in commercial broiler chickens in Italy

A Review of Approaches Targeting the Replacement of Coccidiostat Application in Poultry Production

Coccidiosis: recent advancements in the immunobiology of Eimeria species, preventive measures, and the importance of vaccination as a control tool against these Apicomplexan parasites

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