A New Pyridoxal Derivative for Transamination of <i>N</i>‐Terminus of Proteins

Zhang, Meijuan; Zhang, Xuemei; Li, Juan; Guo, Qing‐Xiang; Xiao, Qin

doi:10.1002/cjoc.201180306

Cited by 14 publications

(13 citation statements)

References 36 publications

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“…Indeed, this underwent the modification of both sites when exposed to RS. Facing another recognised drawback of Francis methodology, namely low efficiency for bulky amino acid termini (Leu, Ile, Val), Zhang et al 621 have elaborated an efficient PLP analogue, FHMDP (Fig. 70), that demonstrated much higher efficiency in transamination thereof.…”

Section: A-amino Groupsmentioning

confidence: 99%

Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation

2015

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Bioconjugation methodologies have proven to play a central enabling role in the recent development of biotherapeutics and chemical biology approaches. Recent endeavours in these fields shed light on unprecedented chemical challenges to attain bioselectivity, biocompatibility, and biostability required by modern applications. In this review the current developments in various techniques of selective bond forming reactions of proteins and peptides were highlighted. The utility of each endogenous amino acid-selective conjugation methodology in the fields of biology and protein science has been surveyed with emphasis on the most relevant among reported transformations; selectivity and practical use have been discussed.

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Section: A-amino Groupsmentioning

confidence: 99%

Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation

2015

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“…[53][54][55] Using the abovementioned comprehensive molecular properties method, Wu and Huang [56] recently developed a micromechanics model describing hot-spot formation in the energetic crystal powders subjected to drop-weight impact. In their theory, contact deformation, friction and chemical reactions at the particle level during the impact loading process were considered and three hot-spot sources were included (see Fig.…”

Section: Molecular Properties and Micromechanics Methodsmentioning

confidence: 99%

“…Initial work at the NAWC was focused on the cook-off of an aluminized, RDX-based explosive, PBXN-109 that was initially confined in a tube with sealed ends. A modified version of this system was developed [90] UB3LYP/ 6-31G(d,p)// UHF/PM3 [90] UB3LYP/ 6-31G(d,p) UB3LYP/ 6-31þG(d) Spark energy (J) [55] at the NSWC. The design of these cook-off systems are relatively simple which facilitates the initial model development.…”

Section: Predictions Of Thermal Stabilitymentioning

confidence: 99%

Theoretical evaluation of sensitivity and thermal stability for high explosives based on quantum chemistry methods: A brief review

Yan

Zeman

2012

Int J of Quantum Chemistry

114

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Over the past 20 years, a number of scientists have conducted numerous fundamental investigations based on quantum chemistry theory into various mechanistic processes that seems to contribute to the sensitivity of energetic materials. A large number of theoretical methods that have been used to predict their mechanical and spark sensitivity are summarized in this article, in which the advantages and disadvantages of these methods, together with their scope of use are clarified. In addition, the theoretical models for thermal stability of explosives are briefly introduced as a supplement. It has been concluded that the current ability to predict sensitivity is merely based on a series of empirical rules, such as simple oxygen balance, molecular properties, and the ratios of C and H to oxygen for different classes of explosive compounds. These are valid only for organic classes of explosives, though some special models have been proposed for inorganic explosives, such as azides. An exact standard for sensitivity should be established experimentally by some new techniques for both energetic compounds and their mixtures. © 2013 Wiley Periodicals, Inc.

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“…3- O -methylpyridoxine (1) [11], 4′- O -methylpyridoxine (2) [9], and 5′- O -methylpyridoxine (3) [12,13] were synthesized as shown in Fig. 1.…”

Section: Methodsmentioning

confidence: 99%

The Generally Useful Estimate of Solvent Systems (GUESS) method enables the rapid purification of methylpyridoxine regioisomers by countercurrent chromatography

Liu

Friesen

Klein

et al. 2015

Journal of Chromatography A

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The TLC-based Generally Useful Estimate of Solvent Systems (GUESS) method was employed for countercurrent chromatography solvent system selection, in order to separate the three synthetic isomers: 3-O-methylpyridoxine, 4′-O-methylpyridoxine (ginkgotoxin) and 5′-O-methylpyridoxine. The Rf values of the three isomers indicated that ChMWat +2 (chloroformmethanol-water 10:5:5, v/v/v) was appropriate for the countercurrent chromatography. The isomer separation was highly selective and demonstrated that the TLC-based GUESS method can accelerate solvent system selection for countercurrent chromatography. Accordingly, the study re-emphasizes the practicality of TLC as a tool to facilitate the rapid development of new countercurrent and centrifugal partition chromatography methods for this solvent system. Purity and structure characterization of all samples was performed by quantitative 1H NMR.

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A New Pyridoxal Derivative for Transamination of N‐Terminus of Proteins

Cited by 14 publications

References 36 publications

Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation

Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation

Theoretical evaluation of sensitivity and thermal stability for high explosives based on quantum chemistry methods: A brief review

The Generally Useful Estimate of Solvent Systems (GUESS) method enables the rapid purification of methylpyridoxine regioisomers by countercurrent chromatography

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