A new quantitative method for estimating glomerular filtration rate and its clinical value

Cheng, Mu-Hua; Zeng, Feng-Wei; Xie, Liangjun; Li, Jianfang; Zhang, Feng; Jiang, Hang

doi:10.1111/cpf.12204

Cited by 5 publications

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From 1982 to 1984, Gates established a method of measuring the GFR and improved on it to make it more consummate (18)(19)(20)(21). Subsequently, 99m Tc-DTPA dynamic renal scintigraphy became a widely used technique in the quantitative evaluation of differential renal function (22)(23)(24)(25)(26).…”

Section: Discussionmentioning

confidence: 99%

Does baseline renal function always decrease after unilateral ureteral severe obstruction? —experimental validation and novel findings by Tc-99m diethylene triamine pentaacetate acid (DTPA) dynamic renal scintigraphy

Yang¹,

Wang²,

Gao³

et al. 2019

Quant. Imaging Med. Surg.

View full text Add to dashboard Cite

Background: There is a lack of consensus concerning changes in renal function after unilateral ureteral obstruction. The aim of this study was to assess the influence of ureteral obstruction on renal morphology and function and to explore the effectiveness of dynamic renal scintigraphy in evaluating obstructive renal function. Methods: We established a model of right ureteral obstruction using New Zealand white rabbits. We measured the glomerular filtration rate (GFR) before the operation and from days 1 to 82 after obstruction, observed the changes in bilateral kidney sizes and the GFR, and then compared the differences between the left and right kidneys. Results: The difference between left and right kidney sizes was not significant before obstruction (t=−0.430, P=0.674); the right kidneys increased in size after obstruction and were larger than the left kidneys (P≤0.001). Obstructed kidneys demonstrated a morphological process of decelerated expansion and retraction. The difference in GFR between the left and right kidneys was not significant before obstruction (t=1.77, P=0.098); during days 1-21 and 42-82 after obstruction, the GFR of the right kidneys decreased and was lower than that of the left kidneys (P<0.001); on day 28, the GFR difference between the left and right kidneys (t=1.62, P=0.130) and the difference in the right kidney GFR before and after obstruction (t=1.03, P=0.323) were not significant. The GFR of obstructed kidneys rapidly declined initially, experienced a tortuous process of repeated dormancies and multiple self-recoveries, and then gradually declined. Conclusions: The GFR in hydronephrotic kidneys is fluctuating. Thus, evaluating the true function of hydronephrotic kidneys using only baseline GFR is difficult; however, combining baseline GFR with renal morphology to assess obstructive renal function and its recoverability can provide more meaningful results.

show abstract

Section: Discussionmentioning

confidence: 99%

Does baseline renal function always decrease after unilateral ureteral severe obstruction? —experimental validation and novel findings by Tc-99m diethylene triamine pentaacetate acid (DTPA) dynamic renal scintigraphy

Yang¹,

Wang²,

Gao³

et al. 2019

Quant. Imaging Med. Surg.

View full text Add to dashboard Cite

show abstract

“…However, they are just estimating equations; clinicians who use them should be familiar with their strengths and weaknesses and understand their potential for significant inaccuracy. Perhaps new methods for determining GFR will eventually make their way into clinical practice (54)(55)(56).…”

Section: Discussionmentioning

confidence: 99%

Clinical Decision Making in a Patient with Stage 5 CKD—Is eGFR Good Enough?

Berns

2015

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

The development and widespread use of serum creatinine concentration-based prediction equations to calculate eGFR have been major advances for detection of patients with CKD and the epidemiologic study of CKD and its outcomes. However, these equations as well as those that also incorporate serum cystatin C concentration provide GFR estimates that, although reasonably precise on average, can differ markedly and in clinically important ways from actual GFR. Thus, it is important that clinicians who use these equations for clinical decisionmaking be familiar with their strengths and weaknesses and have an appreciation of their potential for error. More precise knowledge of actual GFR is important in certain clinical circumstances, including, as presented in this Attending Rounds, patients with stage 5 CKD, in whom decisions regarding dialysis initiation are necessary. Nephrologists should have the ability to accurately determine GFR when needed if clinical circumstances suggest inaccuracy of the calculated eGFR reported by the clinical laboratory.

show abstract

A different scintigraphic approach to evaluate the glomerular filtration rate

Hacıosmanoğlu¹,

Karaçalıoğlu²,

Eyıleten³

et al. 2017

Revista Española de Medicina Nuclear e Imagen Molecular

View full text Add to dashboard Cite

A new quantitative method for estimating glomerular filtration rate and its clinical value

Abstract: The new method for estimating GFR had the better performances compared with the Gates' method and creatinine clearance as estimated by Cockcroft-Gault and MDRD method.

Cited by 5 publications

References 27 publications

Does baseline renal function always decrease after unilateral ureteral severe obstruction? —experimental validation and novel findings by Tc-99m diethylene triamine pentaacetate acid (DTPA) dynamic renal scintigraphy

Does baseline renal function always decrease after unilateral ureteral severe obstruction? —experimental validation and novel findings by Tc-99m diethylene triamine pentaacetate acid (DTPA) dynamic renal scintigraphy

Clinical Decision Making in a Patient with Stage 5 CKD—Is eGFR Good Enough?

A different scintigraphic approach to evaluate the glomerular filtration rate

Contact Info

Product

Resources

About