A New Questionnaire for Gastroesophageal Reflux Disease

Locke, G. Richard; Talley, Nicholas J.; Weaver, Amy L.; Zinsmeister, Alan R.

doi:10.1016/s0025-6196(12)62245-9

Cited by 397 publications

(332 citation statements)

References 35 publications

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“…Internal consistency and test-retest reliability were acceptable (correlation coefficients >0.70). 38 An exception was the intra-class correlation coefficient in the HB group for the HB dimension (correlation coefficient = 0.66), which most probably reflects the small number of patients who had no change on esomeprazole treatment and were thus available to test stability over time (n = 14). We used known-groups validity to compare patient-reported symptom severity (RDQ) with physician-rated symptom severity.…”

Section: Discussionmentioning

confidence: 98%

Symptom overlap in patients with upper gastrointestinal complaints in the Canadian confirmatory acid suppression test (CAST) study: further psychometric validation of the reflux disease questionnaire

Zanten

Armstrong

Barkun

et al. 2007

Aliment Pharmacol Ther

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Section: Discussionmentioning

confidence: 98%

Symptom overlap in patients with upper gastrointestinal complaints in the Canadian confirmatory acid suppression test (CAST) study: further psychometric validation of the reflux disease questionnaire

Zanten

Armstrong

Barkun

et al. 2007

Aliment Pharmacol Ther

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“…The GERQ [13] is a self-administered validated instrument that identifies the onset of GERD symptoms and grades the frequency and severity of symptoms over a prior year. It was a long questionnaire containing 80 questions, making it inconvenient for use in clinical trials.…”

Section: Discussionmentioning

confidence: 99%

“…It was feasible to prevent the recall bias since McColl found that 1-mo was the maximum period over which patients could provide reliable data due to recall errors [14] . Four symptoms were included in the RDQ that may be somewhat different from the definition of the previous studies [10,[12][13] . It would be more accurate to include substernal chest pain and food regurgitation to make a diagnosis of GERD [9,15] .…”

Section: Discussionmentioning

confidence: 99%

Risk factors for gastroesophageal reflux disease, reflux esophagitis and non-erosive reflux disease among Chinese patients undergoing upper gastrointestinal endoscopic examination

Juan¹,

Du²,

Jiang³

et al. 2007

WJG

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AIM:To analyze the spectrum and risk factors of gastroesophageal reflux disease (GERD) based on presenting symptoms and endoscopic findings. METHODS:A cross-sectional survey in a cluster random sample was conducted from November 2004 to June 2005 using a validated Chinese version Reflux Disease Questionnaire (RDQ) and other items recording the demographic characteristics and potential risk factors for GERD. Subjects were defined as having GERD symptoms according to the RDQ score (> 12). All subjects were endoscopied and the definition and severity of erosive esophagitis were evaluated by Los Angeles classification. The statistical analysis was performed with SPSS13.0 programs. RESULTS:Of 2231 recruited participants, 701 (31.40%) patients were diagnosed as having GERD while 464 (20.80%) patients had objective findings of reflux esophagitis (RE). Of those 464 patients, only 291 (13.00%) were reported as subjects with GERD symptoms. A total of 528 (23.70%) patients were found to have GERD symptoms, including 19.50% patients with grade A or B reflux esophagitis, 0.90% with grade C and 0.40% with grade D. On multivariate analysis, old age, male, moderate working burden, divorced/widowed and strong tea drinking remained as significant independent risk factors for erosive esophagitis. Meanwhile, routine usage of greasy food and constipation were considered as significant independent risk factors for non-erosive reflux disease (NERD). CONCLUSION:GERD is one of the common GI diseases with a high occurrence rate in China and its main associated factors include sex, anthropometrical variables and sociopsychological characteristics.

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“…However, several studies have demonstrated the validity and reliability of these questions in identifying cases of GERD. 1,2,11,[26][27][28] Symptoms assessed by questionnaire have correlated with objective complications of GERD, such as esophagitis and esophageal adenocarcinoma. 29,30 Furthermore, to improve our specificity for GERD we restricted our primary endpoint to women who reported at least weekly symptoms.…”

Section: Commentmentioning

confidence: 99%

Postmenopausal Hormone Use and Symptoms of Gastroesophageal Reflux

Jacobson

Moy

Colditz

et al. 2009

Obstetrical &Amp; Gynecological Survey

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Context-Previous studies suggest that elevated levels of estrogen and progesterone, either through endogenous or exogenous sources, increase gastroesophageal reflux.Objective-To evaluate the relationship between symptoms of gastroesophageal reflux disease and postmenopausal hormone therapy, including the use of selective estrogen receptor modulators and over-the-counter hormone preparations.Design, setting, and participants-Prospective cohort study of 51,637 postmenopausal women enrolled in the Nurses' Health Study who provided data on the use of hormone therapy biennially since 1976, and information about symptoms of gastroesophageal reflux in 2002.Main outcome measure-Self-reported symptoms of heartburn or acid-regurgitation occurring at least once a week in the previous year (reflux symptoms).Results-Among eligible participants, 12,018 (23%) women reported reflux symptoms. Compared to women who never used postmenopausal hormones, the multivariate odds ratio (OR) for the risk of reflux symptoms was 1.46 (95% CI 1.36-1.56) for past hormone users, 1.66 (95% CI 1.54-1.79) for current users of estrogen only, and 1.41 (95% CI 1.29-1.54) for current users of combined estrogen and progesterone. The risk of reflux symptoms increased significantly with increasing estrogen dose (P < 0.001) and increasing duration of estrogen use (P < 0.001). Moreover, current selective estrogen receptor modulator users experienced an OR of 1.39 (95% CI 1.22-1.59) for reflux symptoms, and women currently using over-the-counter hormone preparations had an OR of 1.37 (95% CI 1.16-1.62). Conclusions-Postmenopausal use of estrogens, selective estrogen receptor modulators, or overthe-counter hormone preparations is associated with an increased risk of symptoms of gastroesophageal reflux. This suggests a hormonal component to the pathophysiology of gastroesophageal reflux in women.

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A New Questionnaire for Gastroesophageal Reflux Disease

Cited by 397 publications

References 35 publications

Symptom overlap in patients with upper gastrointestinal complaints in the Canadian confirmatory acid suppression test (CAST) study: further psychometric validation of the reflux disease questionnaire

Symptom overlap in patients with upper gastrointestinal complaints in the Canadian confirmatory acid suppression test (CAST) study: further psychometric validation of the reflux disease questionnaire

Risk factors for gastroesophageal reflux disease, reflux esophagitis and non-erosive reflux disease among Chinese patients undergoing upper gastrointestinal endoscopic examination

Postmenopausal Hormone Use and Symptoms of Gastroesophageal Reflux

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