A new resource of hepatic protectant, nor-oleanane triterpenoid saponins from the fruit of Stauntonia brachyanthera

Meng, Dali; Xu, Li-huan; Chen, Chao; Yan, Dan; Fang, Zhong‐Ze; Cao, Yun‐Feng

doi:10.1016/j.jff.2015.04.003

Cited by 19 publications

(9 citation statements)

References 12 publications

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“…The chemical study on this fruit resulted in the isolation of triterpenoid saponins. This research provided useful clues for the fruit of S. brachyanthera as a new resource of food for hepatoprotection [40].…”

Section: Application and Characterization Of Surfactantsmentioning

confidence: 89%

Saponin-Based, Biological-Active Surfactants from Plants

Kręgiel¹,

Berłowska²,

Witońska³

et al. 2017

Application and Characterization of Surfactants

123

106

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Plants have the ability to synthesize almost unlimited number of substances. In many cases, these chemicals serve in plant defense mechanisms against microorganisms, insects, and herbivores. Generally, any part of the plant may contain the various active ingredients. Among the plant, active compounds are saponins, which are traditionally used as natural detergents. The name 'saponin' comes from the Latin word 'sapo,' which means 'soap' as saponins show the unique properties of foaming and emulsifying agents. Steroidal and triterpenoid saponins can be used in many industrial applications, from the preparation of steroid hormones in the pharmaceutical industry to utilization as food additives that exploit their non-ionic surfactant properties. Saponins also exhibit different biological activities. This chapter has been prepared by participants of the Marie Sklodowska-Curie Action-Research and Innovation Staff Exchange (RISE) in the framework of the proposal 'ECOSAPONIN.' Interactions between the participants, including chemists, physicists, technologists, microbiologists and botanists from four countries, will contribute to the development of collaborative ties and further promote research and development in the area of saponins in Europe and China. Although this chapter cannot provide a comprehensive account of the state of knowledge regarding plant saponins, we hope that it will help make saponins the focus of ongoing international cooperation.

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Section: Application and Characterization Of Surfactantsmentioning

confidence: 89%

Saponin-Based, Biological-Active Surfactants from Plants

Kręgiel¹,

Berłowska²,

Witońska³

et al. 2017

Application and Characterization of Surfactants

123

106

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“…Up to now, more than 50 nor-oleanane triterpenoids have been isolated from this plant in our previous studies 7 , 8 , among which YM 11 was the most characteristic component because of its highest content. Therefore, with the aim to support its traditional analgesic applications in China, and take full advantage of this valuable medicinal herb, a series of experiments were designed to evaluate the analgesic properties of both S. brachyanthera and YM 11 , and reveal their possible mechanisms.…”

Section: Introductionmentioning

confidence: 98%

The analgesic activities of Stauntonia brachyanthera and YM11 through regulating inflammatory mediators and directly controlling the sodium channel prompt

Meng

Wang

et al. 2017

Sci Rep

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The analgesic studies on Stauntonia brachyanthera, a traditional Chinese folk medicine used to treat headache, pains and inflammatory diseases in local areas, showed that the EtOH extracts (EESB) and the characteristic ingredient YM11 could significantly inhibit the acetic acid-induced writhing responses by 43.1% and 78.95%, and decrease the xylene-induced ear edemas by 48.9% and 21.4%, respectively. EESB could significantly increase pain threshold of mice in hot-plate test, but the effect of YM11 was not obviously. Further study in formalin test showed the inhibitory effect of YM11 in 2nd phase was more significant than that in 1st phase, revealed the peripheral analgesic activity of YM11. The ELISA and Western Blot analysis suggested that the analgesic mechanisms of YM11 were related to the inhibitions of the expressions of TNF-α, IL-1β and IL-6, and down-regulations of Nav1.8 protein in the left side of L4–6 DRG regulated by MAPKs, in which the levels of p-ERK, p-JNK and p-p38 were all decreased. In addition, the electrophysiological experiments indicated YM11 could reduce the Nav1.8 currents by 46.01% in small-diameter DRG neurons. Therefore, the analgesic activity of S. brachyanthera might be based on the regulation of inflammatory mediators and the directly control of the sodium channel prompt.

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“…(Table 1) showed that 1 had the same aglycone as that of brachyantheraoside A 2 . 18 The comparison of the NMR data of aglycone of 1 with those of brachyantheraoside A 2 suggested that the differences between them were the chemical shis of C-3 and C-28, in which the hydroxyl at C-3 in brachyantheraoside A 2 (Fig. 1), which was named as brachyantheraoside A 7 .…”

Section: Discussionmentioning

confidence: 99%

“…Nor-oleanane triterpenoids were the main compositions of S. brachyanthera based on our previous work. [14][15][16] Although multiple bioactivities had been conrmed, [17][18][19][20] KGA inhibitory effect had been unreported for this rare kind of triterpenoids. In this study, a series of nor-oleanane triterpenoids, including two new ones were isolated from S. brachyanthera by various chromatographic methods.…”

Section: Introductionmentioning

confidence: 99%

Brachyantheraoside A₈, a new natural nor-oleanane triterpenoid as a kidney-type glutaminase inhibitor fromStauntonia brachyanthera

Wei

Wang

et al. 2017

RSC Adv.

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A new resource of hepatic protectant, nor-oleanane triterpenoid saponins from the fruit of Stauntonia brachyanthera

Cited by 19 publications

References 12 publications

Saponin-Based, Biological-Active Surfactants from Plants

Saponin-Based, Biological-Active Surfactants from Plants

The analgesic activities of Stauntonia brachyanthera and YM11 through regulating inflammatory mediators and directly controlling the sodium channel prompt

Brachyantheraoside A₈, a new natural nor-oleanane triterpenoid as a kidney-type glutaminase inhibitor fromStauntonia brachyanthera

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A new resource of hepatic protectant, nor-oleanane triterpenoid saponins from the fruit of Stauntonia brachyanthera

Cited by 19 publications

References 12 publications

Saponin-Based, Biological-Active Surfactants from Plants

Saponin-Based, Biological-Active Surfactants from Plants

The analgesic activities of Stauntonia brachyanthera and YM11 through regulating inflammatory mediators and directly controlling the sodium channel prompt

Brachyantheraoside A8, a new natural nor-oleanane triterpenoid as a kidney-type glutaminase inhibitor fromStauntonia brachyanthera

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Brachyantheraoside A₈, a new natural nor-oleanane triterpenoid as a kidney-type glutaminase inhibitor fromStauntonia brachyanthera