A New Sensitive Method for Studying the Polymorphisms of the Human Low Density Lipoproteins

Bütler, R.; Brunner, E.

doi:10.1111/j.1423-0410.1966.tb04279.x

Cited by 32 publications

(12 citation statements)

References 2 publications

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“…By applying a specifically devised haemagglutination technique [2], an increasing number of new and specific Ag molecular heterogeneities was discovered. Today the Ag system is characterized by not 1 Supported by a research fellowship awarded by the Alexander-von-Humboldt-Stiftung.…”

Section: Introductionmentioning

confidence: 99%

A Population Genetic Study on the Ag Polymorphism in South African Indians and Negroids

Hitzeroth¹,

Bütler²,

Butler-Brunner³

1980

Hum Hered

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Two population samples from South Africa, i. e. 555 Bantu-speaking Negroids and 75 Indians, were tested for selected immunogenetic specificities comprising the Ag polymorphism. Within the Negroid sample a new Ag phenotype (i. e. the 49th) was discovered. Interpopulational comparisons involving the present two, as well as three previously studied samples, reveal characteristic differences in regard to the frequency distribution of Ag phenotypes, to the Ag allele frequencies and to the occurrence of Ag haplotypes. These results are discussed. All the data could be interpreted satisfactorily in terms of the genetic model regarding the Ag system as postulated by Bütler and his co-workers.

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Section: Introductionmentioning

confidence: 99%

A Population Genetic Study on the Ag Polymorphism in South African Indians and Negroids

Hitzeroth¹,

Bütler²,

Butler-Brunner³

1980

Hum Hered

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“…As previously stressed [4], important information on antibody specificities of anti-Ag sera may be gained from hemagglutination-inhibition tests, because in this particular assay system both specific LDL used in erythrocyte-coating and inhibiting sera may be varied. A total of 2 to 9 different LDL-preparations were used in testing each anti-Ag serum.…”

Section: Resultsmentioning

confidence: 99%

“…The present study offered an opportunity to test the usefulness of our passive hemagglutination method as a tool in the detection of LDL-polymorphism [4] on a large number of sera. One big advantage of the passive hemagglutination method over immunodiffusion tests is the drastically reduced requirement in the amount of monospecific anti sera for Ag-determinations; the reliability of hemagglutination assays equals that of immunodiffusion tests, provided that the system is cali brated optimally.…”

Section: Discussionmentioning

confidence: 99%

Comparative Studies on Anti-Ag Sera in Immunodiffusion and in Passive Hemagglutination Methods

Bütler¹,

Brunner²,

Vierucci³

et al. 1967

Vox Sanguinis

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“…The analysis of these sera was performed by means of the passive haemagglutination/inhibition test [2,3], which was previously shown to be optimal for the demonstration of different antibody specificities in polyspecific antiAg sera [4].…”

Section: Serological Behaviour Of Sera Tu and P 504mentioning

confidence: 99%

Ag(h), an Additional Factor of the Ag System

Bütler¹,

Brunner²,

Morganti³

et al. 1973

Vox Sanguinis

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A New Sensitive Method for Studying the Polymorphisms of the Human Low Density Lipoproteins

Cited by 32 publications

References 2 publications

A Population Genetic Study on the Ag Polymorphism in South African Indians and Negroids

A Population Genetic Study on the Ag Polymorphism in South African Indians and Negroids

Comparative Studies on Anti-Ag Sera in Immunodiffusion and in Passive Hemagglutination Methods

Ag(h), an Additional Factor of the Ag System

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