A New Sesquiterpene Isolated from <i>Lindera aggregata</i> (S<small>IMS</small>) K<small>OSTERM</small>.

The Effect of the Aerial Part of Lindera akoensis on Lipopolysaccharides (LPS)-Induced Nitric Oxide Production in RAW264.7 Cells

“…Aporphines [1], alkaloids [2], sesquiterpenoids [3–5], flavonoids [6], butanolides [6], furanoids [7], chalconoids [8] and phenolic compounds [9,10] are widely distributed in the plants of the genus of Lindera . Some isolates exhibit biological activities, including suppressed the contraction of thoracic aorta [1], anti-mycobacterial [6], anti-inflammatory [11], against human lung cancer cell (SBC-3) [12], inhibitory osteoclast differentiation [10], slowing down of the progression of diabetic nephropathy in mice [12], anti-nociceptivity [13], inhibition on human acyl-coenzyme A cholesterol acyltransferase activity and antioxidation of low density lipoprotein [9].…”

Effects of Linderae radix extracts on a rat model of alcoholic liver injury

“…LR has been used in the treatment of various diseases ( 8 ), with certain studies reporting that LR extracts have a protective effect on ethanol-induced liver injury ( 12 , 20 , 22 ). The activities of ALT and AST are commonly used as reliable markers for clinical monitoring of liver injury or liver function ( 23 , 24 ).…”

“…In recent decades, the use of herbal medicine in the prevention of ALD has attracted increased attention since it is multitargeted and presents less toxic effects ( 5 , 7 ). Linderae radix (LR; known as Wuyao in Chinese), the dried root of Lindera aggregata (Sims) Kosterm., has been frequently used in traditional Chinese medicine for treating various diseases, including abdominal pain and frequent urination ( 8 , 9 ). LR consists of alkaloids, volatile oils and sesquiterpene esters, with alkaloids being the main active component ( 8 , 10 , 11 ).…”

“…Linderae radix (LR; known as Wuyao in Chinese), the dried root of Lindera aggregata (Sims) Kosterm., has been frequently used in traditional Chinese medicine for treating various diseases, including abdominal pain and frequent urination ( 8 , 9 ). LR consists of alkaloids, volatile oils and sesquiterpene esters, with alkaloids being the main active component ( 8 , 10 , 11 ). Previous studies have found that total alkaloids in LR exert an anti-inflammatory effect by blocking the nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways ( 10 , 11 ).…”

“…A water extract of LR has been found to exert a cytoprotective activity against ethanol-induced acute gastric injury, and this protective activity was possibly mediated by endogenous prostaglandins and the vagus nerve ( 13 ). Certain previous studies have identified the active ingredients of LR and their pharmacological effects, such as the anti-inflammatory effect of alkaloids in the cardiovascular system and the anti-fatigue effect of flavonoids ( 8 – 11 , 14 ); however, further research focusing on the protective effects of LR on the liver has rarely been reported.…”