A new simple and rapid HPLC method for determination of DEHP in PVC packaging and releasing studies

Aignasse, M.F.; Prognon, Patrice; Stachowicz, M.; Gheyouche, R.; Pradeau, D.

doi:10.1016/0378-5173(94)00204-i

Cited by 40 publications

(18 citation statements)

References 5 publications

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“…Since only DEHP was found in some samples, the chromatographic system was set in order to determine DEHP only, in a shorter analysis time. 24 Table 2 presents the amount of plasticizers in the investigated materials. Only DEHP was found in the obtained extracts from the bags.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Migration of phthalate-based plasticizers from PVC and non-PVC containers and medical devices

Veiga¹,

Bohrer²,

Nascimento³

et al. 2012

J. Braz. Chem. Soc.

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A presença de cinco plastificantes derivados de ftalatos em equipamentos para administração intravenosa de soluções e em hemodialisadores (HD), que são feitos tanto de policloreto de vinila (PVC) quanto de outros materiais poliméricos, foi investigada. Destes ftalatos, o único autorizado por agências reguladoras é o di-(2-etilhexil) ftalato (DEHP) em equipamentos de PVC. A determinação foi feita por chromatografia líquida de alta eficiência (HPLC) com detecção UV. Os resultados mostraram que as bolsas para infusão que são feitas tanto de PVC quanto de etil vinil acetato (EVA) contêm apenas DEHP. Entretanto, as mangueiras dos equipos de infusão e dos HD, bem como as fibras capilares dos HD feitas de celulose, contêm não só DEHP, mas também ftalato de dibutila (DBP). Todos os cinco ftalatos investigados foram encontrados nos capilares dos HD feitos de polisulfona. A migração de DEHP para soluções (aminoácidos, glicose e salina) armazenadas em bolsas ocorreu com taxas diferentes para os dois polímeros. Enquanto que para as bolsas de PVC o DEHP foi encontrado em soluções já nos primeiros dias de contato, para as bolsas de EVA a migração iniciou após aproximadamente 6 meses de armazenamento. Como os dispositivos analisados, com exceção das bolsas, contém, além do DHEP, outros ftalatos, o risco posto aos pacientes deve ser motivo de preocupação.The presence of five plasticizer phthalates in bags and sets for intravenous administration and hemodialyzers (HD), which are made of polyvinyl chloride (PVC) and of other polymeric materials, was investigated. Di-(2-ethylhexyl) phthalate (DEHP) in PVC is the only authorized phthalate by regulatory agencies. Phthalate determination was carried out by high resolution liquid chromatograph (HPLC) with UV detection. The results showed that the infusion bags that are made of both PVC and ethylene vinyl acetate (EVA) contained only DEHP. In contrast, the tubing of infusion sets and of HD (as well as the cellulose capillaries of HD) contained not only DEHP but also dibutyl phthalate (DBP). Moreover, all five investigated phthalates were found in HD polysulfone capillaries. Migration of DEHP into the stored solutions (amino acids, glucose and saline) in bags occurred at different rates from one polymer to another. While DEHP from PVC bags was found in solutions within the first days of contact, the migration from EVA bags started only after approximately 6 months of solution storage. Since PVC and non-PVC devices (as well as capillaries of HD sets) contain DEHP and other phthalate-based plasticizers, the extent of the risk that they pose to patients remains a matter of concern.

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Section: Resultsmentioning

confidence: 99%

“…For the determination of DEHP alone, the mobile phase was acetonitrile:methanol (9:1, v/v) at a flow rate of 0.8 mL min -1 without gradient. 24,25 The measurement was carried out at 220 nm and a sample loop of 20 µL was used. A blank sample (hexane) was injected 6 times to calculate the limit of detection (LOD).…”

Section: Chromatographic Separationmentioning

confidence: 99%

Migration of phthalate-based plasticizers from PVC and non-PVC containers and medical devices

Veiga¹,

Bohrer²,

Nascimento³

et al. 2012

J. Braz. Chem. Soc.

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“…Levels of the most frequently studied plasticizer, diethylhexylphthalate, were analyzed with highperformance liquid chromatography involving a 150 ϫ 4.6 -mm ODS C18 column (Phe- nomenex, Torrance, CA); acetonitrile:methanol (90:10, v/v) mobile phase; 1.0 min/mL flow rate; and ultraviolet detection at 222 nm. The high-performance liquid chromatography method was adapted from (14) and validated for a minimum diethylhexylphthalate detection level of 0.003 g/mL. Diethylhexylphthalate concentrations below this were recorded as zero.…”

Section: Methodsmentioning

confidence: 99%

A wet-primed extracorporeal membrane oxygenation circuit with hollow-fiber membrane oxygenator maintains adequate function for use during cardiopulmonary resuscitation after 2 weeks on standby*

Karimova

Robertson

Cross

et al. 2005

Critical Care Medicine

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“…Several authors reported increasing DEHP release during the experimental period. [2][3][4] The extraction of DEHP was highly dependent on the temperature of the leaching solution, but also on the plasticized PVC formulation and on the initial quantity of DEHP.…”

Section: Introductionmentioning

confidence: 99%

Leaching of plasticized PVC: Effect of irradiation

Colombani

Herbette²,

Rossi

et al. 2009

J of Applied Polymer Sci

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Highly irradiated (2-26 MGy) polyvinyl chloride (PVC) was leached in an alkaline solution to investigate the impact of high doses on the leaching process and on the nature of the leaching products. The results show that leaching is controlled by diffusion phenomena as described by Fick's second law. The apparent diffusion coefficient (D a ) of plasticized PVC leaching products can be calculated for each sample. Irradiation at high dose causes D a to diminish; this can be attributed to crosslinking and grafting reactions occurring during irradiation.The material microstructure thus becomes less permeable during radiolysis, which slows down the migration of species. Organic products of leaching are plasticizers contained in plasticized PVC or their degradation products. The main organic leaching products are phthalic ions formed by the hydrolysis of phthalic esters in alkaline leaching solution.

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A new simple and rapid HPLC method for determination of DEHP in PVC packaging and releasing studies

Cited by 40 publications

References 5 publications

Migration of phthalate-based plasticizers from PVC and non-PVC containers and medical devices

Migration of phthalate-based plasticizers from PVC and non-PVC containers and medical devices

A wet-primed extracorporeal membrane oxygenation circuit with hollow-fiber membrane oxygenator maintains adequate function for use during cardiopulmonary resuscitation after 2 weeks on standby*

Leaching of plasticized PVC: Effect of irradiation

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