Clinopodium rankiniae, a new species from the SE region of Cuba, is described and illustrated. It appears to be closely related to the other endemic species of Cuba and Hispaniola (C. alpestre, C. banaoense, C. bucheri and C. ekmanianum), which grow isolated in mountainous ecosystems. It differs primarily by the disposition of the leaves (mostly on short, lateral brachyblasts), the colour of the corolla (white, with a very light purple tinge) and the hirsute to tomentose calyx.