Pancreatic cancer is the third most common cancer in the gastrointestinal tract and the fourth leading cause of cancer death in most western or industrialized countries [1] . Over 95% of pancreatic malignancies originate in the pancreatic ducts and are adenocarcinomas by histology. The 5-year survival rate is < 5%, and of the 10%-20% of patients with resectable disease, only approximately 1 in 5 will survive the next 5 years. Despite great scientific effort and large increases in knowledge of the cellular events leading to pancreatic adenocarcinoma, survival rates have not changed significantly over the last 20 years. Furthermore, our understanding of the biology of this carcinoma, such as initiation, progression, and metastasis formation remains to be elusive. Only 5%-10% of all pancreatic adenocarcinomas have a clear hereditary association, and cigarette smoking, chronic pancreatitis and adult onset diabetes of less than two years' duration are the only consistently identified and modifiable risk factors [2][3][4]