A new, third generation, PVC/TTF–TCNQ composite amperometric biosensor for glucose determination

Cano, Manuel; Ávila, J.; Mayén, M.; Mena, M.L.; Pingarrón, José M.; Rodríguez‐Amaro, Rafael

doi:10.1016/j.jelechem.2007.11.032

Cited by 25 publications

(15 citation statements)

References 19 publications

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“…In all cases, the biosensors contained 24 units GOx and the final potential of 0.15 V exhibited the best response (shown in Fig. 1), in accordance with the previously optimized results for a composite GOx-TTF-TCNQ biosensor [29].…”

Section: Response To Glucose Of the Different Biosensorssupporting

confidence: 89%

“…We have obtained a value of 8.7 ± 0.5 mM for the apparent Michaelis-Menten constant, K app m , determined from the corresponding Lineaweaver-Burk plot. This value is similar to those reported on the free enzyme and to that obtained when using the TTF-TCNQ composite biosensor without gold [29], which clearly indicates that the gold nanoparticles environment does not affect the glucose affinity of the enzyme in the biosensor.…”

Section: Effect Of Au Concentration On the Biosensor Responsesupporting

confidence: 88%

“…11%). As this behavior is similar to that of the biosensor without gold nanoparticles [29], it is evident that the presence of the gold nanoparticles is entirely compatible with the bioactivity and stability of the immobilized GOx.…”

Section: Stabilitysupporting

confidence: 64%

“…1, the composites based on colloidal gold show an evident enhancing analytical performance in comparison with the biosensor without Au coll (curve a) [29], thus showing the catalytic effect of colloidal gold on the enzymatic reaction. The biosensor based on Au coll incorporated into the composite (curve e) shows a wider range of linearity as well as a greater sensitivity.…”

Section: Response To Glucose Of the Different Biosensorsmentioning

confidence: 91%

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A gold nanoparticle-modified PVC/TTF-TCNQ composite amperometric biosensor for glucose determination

Sánchez-Obrero

Ávila

Mayén

et al. 2009

Journal of Electroanalytical Chemistry

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Section: Response To Glucose Of the Different Biosensorssupporting

confidence: 89%

Section: Effect Of Au Concentration On the Biosensor Responsesupporting

confidence: 88%

Section: Stabilitysupporting

confidence: 64%

Section: Response To Glucose Of the Different Biosensorsmentioning

confidence: 91%

See 2 more Smart Citations

A gold nanoparticle-modified PVC/TTF-TCNQ composite amperometric biosensor for glucose determination

Sánchez-Obrero

Ávila

Mayén

et al. 2009

Journal of Electroanalytical Chemistry

Self Cite

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“…Nanomaterials as gold nanoparticles [14,15], carbon nanotubes [16] have also been used in order to improve the electronic transfer between the electroactive center of the enzyme and the surface electrode (3 rd generation sensor) [17]. These sensors would not need any mediator but in the most of the cases, those sensors with nanogolds or nanotubes need some compound as mediator [18,19], which can offer an improvement of sensitivity. The immobilization of the enzyme and the mediator is a very important step.…”

Section: Introductionmentioning

confidence: 99%

Enzymatic Sensor Using Mediator‐Screen‐Printed Carbon Electrodes

et al. 2010

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A new glucose sensor was developed using screen-printed ferrocyanide/carbon electrodes. The ferrocyanide is included in the carbon ink of the commercial screen-printed electrode. The immobilization of enzymes glucose oxidase (Gox) and horseradish peroxidase (HRP) were carried out in a very easy way. An aliquot of 10 mL of a Gox/ HRP mixture was deposited on the electrode surface and left there until dried (approximately 1 h) at room temperature. The ferricyanide generated enzymatically was detected amperometrically applying a potential of À0.1 V (vs. Ag pseudo reference electrode). The sensor, so constructed, shows a good sensitivity to glucose (À2.12 mA/mM) with a slope deviation of AE 0.06 mA/mM and a linear range comprised between 0.05 and 1 mM of glucose, with a limit of detection of 0.025 mM. These sensors show good intersensor reproducibility and a high stability. When they are stored at 4 8C, no significant changes in the slope value of the glucose calibration plot were found after 3 months. Glucose was determined in real samples as honey, blood, drink for babies and glucosed drink with a great accuracy.

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Volumetric Electron Transfer from Metabolites to Chemically Doped Polymer Electrodes

Tan

Lee

Rozylowicz

et al. 2023

Adv Funct Materials

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The development of sensor electrode materials for the detection of metabolites will enable point‐of‐care diagnostic devices for the monitoring and treatment of metabolic diseases such as diabetes. Current state‐of‐the‐art glucose sensing electrodes employ the organic salt tetrathiafulvene tetracyanoquinodimethane (TTF TCNQ) to receive electrons directly from enzymatic reactions of glucose. However, TTF TCNQ is insoluble in most solvents, making it challenging to deposit high‐quality electrodes. Furthermore, its hydrophobicity hinders its interface with aqueous solutions in physiological environments. To overcome these issues, TCNQ derivatives are introduced into an electron‐rich and hydrophilic conjugated polymer. Thus, a polymeric electrode is demonstrated that is easily solution processible and can undergo volumetric direct electron transfer with glucose reactions throughout its bulk. This study further elucidates the electron transfer mechanism during chemical doping and metabolite sensing reactions to inform general design rules for this new class of glucose sensing materials.

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A new, third generation, PVC/TTF–TCNQ composite amperometric biosensor for glucose determination

Cited by 25 publications

References 19 publications

A gold nanoparticle-modified PVC/TTF-TCNQ composite amperometric biosensor for glucose determination

A gold nanoparticle-modified PVC/TTF-TCNQ composite amperometric biosensor for glucose determination

Enzymatic Sensor Using Mediator‐Screen‐Printed Carbon Electrodes

Volumetric Electron Transfer from Metabolites to Chemically Doped Polymer Electrodes

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