A new tissue adhesive for laceration repair in children

Bruns, Thomas; Smith, R. C.; Kile, Dale L.; Davis, Derek; Sullivan, KM; Quinn, Jim V.

doi:10.1097/00006527-199919040-00012

Cited by 7 publications

(14 citation statements)

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“…Nineteen articles were selected as potentially relevant. [11][12][13][14][15][16][17][18][19][20][21][22][23][32][33][34][35][36][37] One additional article, 38 identified through the Cochrane Wounds Group Specialized Trials Register, was considered potentially relevant based on the title. The reviewers identified two additional abstracts 24,39 during regular review of a current emergency medicine journal, which had yet to be indexed in Medline.…”

Section: Resultsmentioning

confidence: 99%

“…4 There is an increasing amount of literature supporting the use of TAs for various minor lacerations, [5][6][7][8][9][10] including a number of randomized controlled trials (RCTs) that support TAs in their respective study populations. [11][12][13][14][15][16][17][18][19][20][21][22][23][24] However, due to the wide variation in study parameters, there are no generalizable, definitive answers about the effectiveness of TAs.…”

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confidence: 99%

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Tissue Adhesives for Traumatic Lacerations: A Systematic Review of Randomized Controlled Trials

et al. 2003

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Objective: To summarize the best available evidence for the effect of tissue adhesives (TAs) in managing traumatic lacerations in children and adults. Methods: A search was conducted using the Cochrane Controlled Trials Register, Medline, and EMBase for relevant studies. The authors also searched the citations of selected studies and contacted relevant authors and manufacturers. The search included randomized controlled trials (RCTs) comparing a TA versus standard wound closure (sutures, staples, adhesive strips) (SWC) or two TAs for acute, linear, low-tension, traumatic lacerations in an emergency or primary care setting. Data were extracted by one reviewer and checked for accuracy by a second reviewer. Two reviewers independently assessed masked copies for quality. Outcomes of cosmesis (subgroups of age, wound location, and need for deep sutures), pain, procedure time, ease of use, and complications were analyzed separately for two comparisons: 1) TA versus SWC; and 2) TA versus TA. Results: Eight studies compared a TA with SWC. No significant difference was found for cosmesis at any time point examined. Subgroup analysis was possible only for age; no significant difference was found. Pain scores [Parent Visual Analogue Scale weighted mean difference (VAS WMD) ¼ ÿ15.7 mm; 95% CI ¼ ÿ21.9 to ÿ9.5] and procedure time (WMD ¼ ÿ5.7 minutes; 95% CI ¼ ÿ8.2 to ÿ3.1) significantly favored TAs. Small, statistically significant risk differences were found for dehiscence [favoring SWC; number needed to harm (NNH) ¼ 25; 95% CI ¼ 14 to 100] and erythema (favoring TAs; NNH ¼ 8; 95% CI ¼ 4 to 100). Only one study compared two TAs (butylcyanoacrylate versus octylcyanoacrylate) for pediatric facial lacerations. No significant difference was found for cosmesis, pain, procedure time, or complications. Conclusions: TAs are an acceptable alternative to SWC for simple traumatic lacerations. No difference in cosmesis was found between TAs and SWC, or between different TAs. Tissue adhesives offer the benefits of decreased procedure time and less pain, compared with SWC. A small increased rate of dehiscence with TAs must be considered when choosing the closure method (NNH ¼ 25).

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Tissue Adhesives for Traumatic Lacerations: A Systematic Review of Randomized Controlled Trials

et al. 2003

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“…6,7 Since then extensive descriptive and comparative studies have been conducted to confirm their role as a favourable option in closing superficial wounds. [8][9][10][11][12][13] Different cyanoacrylate compounds have been synthesised which are unique in their clinical properties. The cyanoacrylates have been found to be safe for clinical use with no reports of adverse effects or carcinogenicity.…”

Section: Introductionmentioning

confidence: 99%

Economic aspect of tissue glue in thyroid surgeries

Pillai

2018

Int J Otorhinolaryngol Head Neck Surg

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Background: Tissue glue or adhesives are the recent advances in closure of the skin wound. They have been used as an alternative to the sutures, staples and plasters. They have been found to be cosmetically better compared to other modes of wound closure. Whether the tissue glues are economically feasible for routine use has to be found out. The aims and objectives of this study is to find out the cost-effectiveness of tissue glue in comparison with traditional suture technique in thyroid surgeries.Methods: This is a prospective study to find out the economic aspect of tissue glue in comparison with silk suture in fifty three patients who underwent thyroidectomy at Kasturba Medical College, Manipal. Results: The overall cost for tissue glue procedure was significantly less when compared to silk suture technique. Conclusions: Iso amyl-2-cyanoacrylate is excellent tissue glue. Though the initial cost of tissue glue is higher compared to silk sutures, the overall cost including the anaesthetic cost, hospital stay and reviews is considerably less. Thus we conclude that the tissue glue is economically cheaper compared to suture methods.

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“…Pineros-Fernandez et al (10) used CyAc to repair peripheral nerves, Bruns et al (11) used it to repair skin lacerations, and Gulalp et al (12) used it to repair incisions of the skin and mucosa. Several papers have reported satisfactory aesthetic and functional results using CyAc (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

“…Several papers have reported satisfactory aesthetic and functional results using CyAc (10)(11)(12). Some studies have reported increased inflammation and fibrosis, but primarily, when first-generation short-chain materials were used.…”

Section: Introductionmentioning

confidence: 99%

Histopathological Effects of Fibrin Glue and Cyanoacrylate on the Maxillary Sinus

Sarıkaya

Bişkin

Damar

et al. 2016

Turk Arch Otorhinolaryngol

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Objective: To compare the histopathological effects of fibrin glue (FbGl) and cyanoacrylate (CyAc) on the maxillary sinus mucosa.Methods: Twenty rabbits were divided into two groups of 10, and surgical defects were created in the maxillary sinuses. The right maxillary sinus was treated with FbGl in one group and with CyAc in the other group. As a control, the left maxillary sinuses of all rabbits were treated with sterile saline solution. One rabbit treated with CyAc died during the study and was excluded. On postoperative day 21, all animals were sacrificed. Maxillary sinus mucosa samples were studied to determine the extent of inflammation and fibrosis, foreign body reaction, cilia loss, increased osteogenesis in bony structures under the mucosa, and loss of serous glands.

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A new tissue adhesive for laceration repair in children

Cited by 7 publications

References 0 publications

Tissue Adhesives for Traumatic Lacerations: A Systematic Review of Randomized Controlled Trials

Tissue Adhesives for Traumatic Lacerations: A Systematic Review of Randomized Controlled Trials

Economic aspect of tissue glue in thyroid surgeries

Histopathological Effects of Fibrin Glue and Cyanoacrylate on the Maxillary Sinus

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