A New Triterpene Hexaglycoside from the Bark of Kalopanax septemlobus (Thunb.) Koidz.

Abstract

The new triterpene glycoside 3-O-β-D-xylopyranosyl-(1→4)-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosylhederagenin 28-O-β-D-gluco-pyranosyl-(1→6)-β-D-glucopyranoside, named septemoside A (1), and the known 3-O-α-L-rhamnopyranosyl-(1→2)-O-α-L-arabinopyranoside-28-O-β-D-glucopyran-osyl-(1→6)-O-β-D-glucopyranosyl ester of hederagenin (2), were isolated from the bark of Kalopanax septemlobus. The structure elucidation of the compounds was based on spectroscopic evidence, including HRESIMS, 1D and 2D-NMR analysis.

Ethanol extract of Kalopanax septemlobus leaf induces caspase-dependent apoptosis associated with activation of AMPK in human hepatocellular carcinoma cells

“…(Araliacieae; common name: prickly castor oil tree), which is widely recognized in its native region of northeastern Asia as a treatment for rheumatic arthritis, nephritis edema, cholera, dysentery, and neurotic pain. The extracts and/or components that K. septemlobus possess have been confirmed recently to have pharmacological activities ranging from anti-oxidant, anti-inflammatory, and hypoglycemic functions to regulation of neurite outgrowth (43)(44)(45)(46). The molecular mechanisms underlying the effects of K. septemlobus extracts appear to involve apoptosis, but the precise pathways have not been elucidated to date.…”