A new type of antisweet principles occurring in

Yoshikawa, Kazuko; Arihara, Shigenobu; Matsuura, Kouji

doi:10.1016/s0040-4039(00)74887-8

Cited by 36 publications

(17 citation statements)

References 6 publications

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“…Pharmacological studies showed that G. sylvestre has hypoglycemic [4,5], anti-caries [6,7] and weight reducing [8,9,10] effects. Triterpenoids [11,12,13,14,15,16,17,18], cyclitols [19], flavonoids [20], peptides [21], pectin [22] and alkaloids [23,24] have been isolated from this plant. Some triterpene saponins from G. sylvestre were found to be able to attenuate hyperglycemia induced by pituitary growth hormone or adrenocorticotropic hormone [25,26] and to inhibit intestinal glucose absorption in diabetic rats [27,28,29,30].…”

Section: Introductionmentioning

confidence: 99%

New Pregnane Glycosides from Gymnema sylvestre

Yang

Zhang

et al. 2015

Molecules

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Abstract:Four new pregnane glycosides 1-4 were isolated from the ethanol extract of the stem of Gymnema sylvestre and named gymsylvestrosides A-D. Hydrolysis of compound 1 under the catalysis of Aspergilus niger β-glucosidase afforded compound 5 (gymsylvestroside E). Their structures were determined by spectroscopic methods such as HRESIMS, 1D and 2D NMR, as well as HMQC-TOCSY experiment. Compounds 1-4 were screened for Saccharomyces cerevisiae α-glucosidase inhibitory activity.

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Section: Introductionmentioning

confidence: 99%

New Pregnane Glycosides from Gymnema sylvestre

Yang

Zhang

et al. 2015

Molecules

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“…G. sylvestre leaf contains more than 20 saponin glycosides. The major saponin fraction comprises of gymnemic acid (the anti-sweet principle) which is a complex mixture of at least nine closely related acidic glycosides (Yoshikawa et al 1991), also 23-hydroxylongispinogenin, gymneastrogenin (pentahydroxyoleane-12-ene) and a few dammarane derivatives as aglycones, that makes the purification and characterization of gymnemic acid a difficult task. Neverthless, a quantitative analysis of gymnemic acid by HPLC analysis of gymnemagenin, the common aglycone obtained on hydrolysis has been reported by Toshihiro et al (1994).…”

Section: Introductionmentioning

confidence: 99%

Elicitor-enhanced production of gymnemic acid in cell suspension cultures of Gymnema sylvestre R. Br.

Veerashree

Anuradha

Kumar

2011

Plant Cell Tiss Organ Cult

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Cell suspension cultures of Gymnema sylvestre treated with four different elicitors, methyl jasmonate (MJ), yeast extract, chitin and pectin were studied for the production of gymnemic acid as gymnemagenin equivalent, that was analyzed by high performance liquid chromatography (HPLC). All the four tested elicitors induced gymnemic acid production in cell suspension cultures. Highest gymnemic acid content was achieved following treatment with yeast extract (100.47 ± 0.28 mg/l), this was followed by MJ (70.43 ± 0.26 mg/l), pectin (64.19 ± 0.23 mg/l) and chitin (62.72 ± 0.13 mg/l). The addition of elicitors has shown a significant influence on cell growth that affected cell growth compared to respective controls. The highest gymnemic acid production was obtained after 20 days of elicitation in cultures treated with 0.5 g l -l yeast extract, it was 5.25-folds greater than in control. These results suggest that the addition of an elicitor to Gymnema sylvestre cell suspension cultures could stimulate and enhance gymnemic acid production. In our present study we could able to overproduce gymnemic acid up to 51.97 ± 0.26 mg l -l (dry weight basis) in yeast extract treated cell suspension cultures.

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“…Kurihara et al [33] have suggested that the acyl groups might play an important role in the generation of the antisweet activity. However, it seems that acyl groups only increase the antisweet activity, but are not essential [34]. A 0.5 mM solution of gymnemic acids VIII ( 8 ), IX ( 9 ) and X ( 10 ) leads to a complete suppression of the sweet taste of 0.2 M sucrose.…”

Section: Triterpenoids From Gymnema Sylvestre and Their Pharmacolomentioning

confidence: 99%

Triterpenoids from Gymnema sylvestre and Their Pharmacological Activities

Fabio¹,

Romanucci²,

Marco³

et al. 2014

Molecules

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Because plants are estimated to produce over 200,000 metabolites, research into new natural substances that can be used in the pharmaceutical, agrochemical and agro-industrial production of drugs, biopesticides and food additives has grown in recent years. The global market for plant-derived drugs over the last decade has been estimated to be approximately 30.69 billion USD. A relevant specific example of a plant that is very interesting for its numerous pharmacological properties, which include antidiabetic, anticarcinogenic, and neuroprotective effects is Gymnema sylvestre, used as a medicinal plant in Asia for thousands of years. Its properties are attributed to triterpenoidic saponins. In light of the considerable interest generated in the chemistry and pharmacological properties of G. sylvestre triterpenes and their analogues, we have undertaken this review in an effort to summarise the available literature on these promising bioactive natural products. The review will detail studies on the isolation, chemistry and bioactivity of the triterpenoids, which are presented in the tables. In particular the triterpenoids oxidised at C-23; their isolation, distribution in different parts of the plant, and their NMR spectral data; their names and physico-chemical characterisation; and the biological properties associated with these compounds, with a focus on their potential chemotherapeutic applications.

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A new type of antisweet principles occurring in

Cited by 36 publications

References 6 publications

New Pregnane Glycosides from Gymnema sylvestre

New Pregnane Glycosides from Gymnema sylvestre

Elicitor-enhanced production of gymnemic acid in cell suspension cultures of Gymnema sylvestre R. Br.

Triterpenoids from Gymnema sylvestre and Their Pharmacological Activities

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