A new vaccine adjuvant (BOS 2000) a potent enhancer mixed Th1/Th2 immune responses in mice immunized with HBsAg

Khajuria, Anamika; Gupta, Amit; Malik, Fayaz; Singh, Surjeet; Singh, Jaswant; Gupta, B. K.; Suri, K. A.; Suden, Pankaj; Srinivas, V. K.; Ella, Krishna M.; Qazi, G. N.

doi:10.1016/j.vaccine.2007.03.051

Cited by 45 publications

(28 citation statements)

References 17 publications

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“…Many polysaccharides have been shown to potentiate immune response, such as -inulin, a human polysaccharide for HBsAg [293], Advax, a inulin-based polysaccharide for Japanese encephalitis vaccine in mice [296], PAP, a water-soluble polysaccharide from the mycelium of Polyporus albicans (edible fungus) for subcutaneous immunization of mice with ovalbumin [297], BOS 2000 (polysaccharides from Boswellia serrata) for hepatitis B in mice [298], lentinan (a (1-3)-beta-D-glucan from the mushroom Lentinus edodes) or its sulfated form for Newcastle disease (ND) vaccine [299]. Their effects can be more effective than alum-based vaccine [296,298].…”

Section: Lipopolysaccharides/polysaccharidesmentioning

confidence: 99%

“…Their effects can be more effective than alum-based vaccine [296,298]. Intradermal administration of bovine serum albumin conjugated to microparticulate β-glucan (MG) from yeast Saccharomyces cerevisiae enhanced the primary IgG antibody response to BSA in a manner comparable to the prototypic complete Freund's adjuvant in mice [300].…”

Section: Lipopolysaccharides/polysaccharidesmentioning

confidence: 99%

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Selection of Adjuvants for Enhanced Vaccine Potency

Wang¹,

Singh²

2011

WJV

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Section: Lipopolysaccharides/polysaccharidesmentioning

confidence: 99%

Section: Lipopolysaccharides/polysaccharidesmentioning

confidence: 99%

Selection of Adjuvants for Enhanced Vaccine Potency

Wang¹,

Singh²

2011

WJV

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“…In addition, the number of adjuvant candidates isolated or purified from various medicinal plants e.g. Picrorhiza kurroa (61), Boswellia serrata (62), Emblica officinalis (19) etc., showed remarkable activity against a number of vaccine antigens.…”

Section: Example Of Plant-based Adjuvant-qs21mentioning

confidence: 99%

Vaccine Adjuvants: The Current Necessity of Life

Gupta

Chaphalkar

2015

Shiraz E-Med J

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Context:Vaccination is considered as the most cost effective method for the prevention of human diseases. For this prevention method, we need certain substances to increase or boost the antibody as well as cell-mediated immune response against various bacterial as well as viral pathogens. Until now, alum was considered as the safest adjuvant for human use, licensed by the United States Food and Drug Administration. Due to the poor adjuvanticity of alum, conventional vaccines require multiple recall injections, at different time intervals, to attain or sustain the optimal immune response. The present review discusses about the necessity of adjuvants for vaccines. Evidence Acquisition: A number of factors such as slow release of antigen (depot effect), more efficient delivery of antigen to draining lymph nodes, non-specific activation of antigen-presenting cells or of B and/or T-lymphocytes, increased uptake of antigen by antigenpresenting cells or increased recruitment of immune cells to the site where the antigen is present, can contribute to increased immune responses to immunization. Many of these factors involve the interaction of various immune system components and specific anatomical features, making them difficult to replicate in model systems in vitro. Results: Despite the development of many potent adjuvant formulations with vaccine antigen during the last 80 -90 years, aluminum compounds are still the only approved adjuvants used for routine human vaccines. Conclusions: Based on pre-clinical and preliminary clinical observations, it appears that the range of adjuvants accepted for human vaccines will expand in the coming years.

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“…After 3 days, splenic lymphocytes were stained with 5 ll of FITC-conjugated anti-CD4, followed by simultaneous staining with 5 ll of PE-conjugated anti-rat IFN-c antibody incubated for 30 min at 4°C in the presence of 19 FACS permeabilizing solution. Analysis was carried out on the flow cytometer (BD, LSR) using Cell Quest Pro software [17].…”

Section: Intracellular Ifn-cdetection By Flow Cytometry In Splenocytesmentioning

confidence: 99%