A new variant of Norovirus GII.4/2007 and inter-genotype recombinant strains of NVGII causing acute watery diarrhoea among children in Kolkata, India

Nayak, Malabika; Chatterjee, Debarati; Nataraju, Seegekote Mariyappa; Pativada, Madhusudan; Mitra, U; Chatterjee, Mrinal Kanti; Saha, Tushar Kanti; Sarkar, Ujjal; Krishnan, Triveni

doi:10.1016/j.jcv.2009.04.018

Cited by 45 publications

(31 citation statements)

References 28 publications

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“…In the present study, SaV was detected in 2·7% of children with AG and in 1·9% of asymptomatic children. Our data is similar to other studies from eastern (Kolkata) and northern (Lucknow) India, wherein the frequency of detection of SaV in children with AG was reported between 0·9% and 3·2% [15,20]. SaV prevalence in asymptomatic controls was reported to be lower than in AG cases.…”

Section: Discussionsupporting

confidence: 91%

Epidemiological profile and genetic diversity of sapoviruses (SaVs) identified in children suffering from acute gastroenteritis in Pune, Maharashtra, Western India, 2007–2011

Lasure

Gopalkrishna

2016

Epidemiol. Infect.

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SUMMARYSapoviruses (SaVs) are responsible for sporadic cases and outbreaks of acute gastroenteritis. Despite this, few studies in India have focused on the epidemiological investigation of SaV in cases of acute gastroenteritis. The aim of this study was to understand the molecular epidemiology, genetic diversity and clinical impact of SaV in diarrhoeic children from Pune, Western India. Between 2007 and 2011, a total of 985 faecal samples from diarrhoeic cases and non-diarrhoeic controls were collected and examined for the presence of SaV by nested RT–PCR. SaV was detected in 2·7% (21/778) of the cases and 1·9% (4/207) of the controls. We observed that the majority of SaV mono-infections caused severe gastroenteritis (67%) with clinical manifestations of diarrhoea (100%), vomiting (73%) and dehydration (80%). All known human SaV genogroups were detected in the study. At least eight genotypes were identified from cases and controls. Genogroups GIV and GV, along with genotypes GI.5, GII.4 and GII.6, were discovered for the first time in India. Two GII.4 study strains were found to be 98·5–99% identical, having a novel intra-genogroup recombinant (GII.1/GII.4) recently reported from the Philippines, suggesting probable evidence of recombination. The circulation pattern of SaV genotypes varied during the study period, with GII.1 being predominant in 2007 and 2009, GIV.1 in 2008, and GV.1 in 2011.

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Section: Discussionsupporting

confidence: 91%

Epidemiological profile and genetic diversity of sapoviruses (SaVs) identified in children suffering from acute gastroenteritis in Pune, Maharashtra, Western India, 2007–2011

Lasure

Gopalkrishna

2016

Epidemiol. Infect.

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“…Hospital-based studies from India between 2003 and 2009 reported a 6% prevalence of NoV associated diarrhea among children 5 years of age, [21][22][23][24] which is lower than the current study. This variation could be a result of the detection method used.…”

Section: Discussioncontrasting

confidence: 89%

Norovirus Genogroup II Gastroenteritis in Hospitalized Children in South India

Menon

Sarkar

Moses

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Abstract. The distribution of norovirus (NoV) genogroup II in children 5 years of age admitted to a south Indian hospital with diarrhea was investigated. Viral RNA extracted from 282 stool samples were screened for NoV GII and positive amplicons sequenced. Twenty-eight (9.9%) had NoV GII infection with a median age of 6 months, with more severe episodes of diarrhea among infected (median Vesikari score 13, interquartile range [IQR] 10-15) than children without infection (median score 10, IQR 8-13, P = 0.002). The study documents NoV GII infections as an important cause of gastroenteritis and the genetic diversity of circulating strains.

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“…No evaluation for GII NoVs was performed in this study (25). Multiple epidemiologic investigations have been performed in eastern, western, and southern India (8,9,15,19,(21)(22)(23). The majority of these studies examined outpatient or hospitalized children with acute gastroenteritis for NoV infection by RT-PCR.…”

Section: Discussionmentioning

confidence: 99%

Noroviruses as a Cause of Diarrhea in Travelers to Guatemala, India, and Mexico

et al. 2010

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Noroviruses (NoVs) are increasingly being recognized as an important enteric pathogen of gastroenteritis worldwide. The prevalence of NoVs as a cause of diarrhea acquired by travelers in developing countries is not well known. We examined the prevalence and importance of NoV infection in three international traveler cohorts with diarrhea acquired in three developing regions of the world, Mexico, Guatemala, and India. We also characterized the demographics and symptoms associated with NoV diarrhea in these travelers. Stool samples from 571 international travelers with diarrhea were evaluated for traditional enteropathogens. NoVs were identified using reverse transcription-PCR and probe hybridization. NoVs were identified in 10.2% of cases of travelers' diarrhea and, overall, was the second most common pathogen, following diarrheagenic Escherichia coli. The detection of NoV diarrhea significantly varied over the three study time periods in Guadalajara, Mexico, ranging from 3 of 98 (3.0%) diarrheal stools to 12 of 100 (12.0%) fecal specimens (P ‫؍‬

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A new variant of Norovirus GII.4/2007 and inter-genotype recombinant strains of NVGII causing acute watery diarrhoea among children in Kolkata, India

Cited by 45 publications

References 28 publications

Epidemiological profile and genetic diversity of sapoviruses (SaVs) identified in children suffering from acute gastroenteritis in Pune, Maharashtra, Western India, 2007–2011

Epidemiological profile and genetic diversity of sapoviruses (SaVs) identified in children suffering from acute gastroenteritis in Pune, Maharashtra, Western India, 2007–2011

Norovirus Genogroup II Gastroenteritis in Hospitalized Children in South India

Noroviruses as a Cause of Diarrhea in Travelers to Guatemala, India, and Mexico

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