1999
DOI: 10.1109/23.775579
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A new X-ray computed tomography system for laboratory mouse imaging

Abstract: Two versions of a new high-resolution x-ray computed tomography system are being developed to screen mutagenized mice in the Oak Ridge National Laboratory Mammalian Genetics Research Facility. The first prototype employs a single-pixel cadmium zinc telluride detector with a pinhole collimator operating in pulse counting mode. The second version employs a phosphor screedCCD detector operating in current mode. The major system hardware includes a low-energy x-ray tube, two linear translation stages and a rotatio… Show more

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Cited by 92 publications
(40 citation statements)
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“…Next, the rats were euthanized by a 20 mEq intravenous injection of KCI solution. Heparinized saline (5000 units=100 cm 3 ) and a vasodilator (Lidocaine, 1 mg=kg) were used to ush the vascular system, followed by infusion of microÿl (a silicon polymer containing lead chromate) at 100 mm Hg pressure using a Harvard pump. As soon as the microÿl entered both venaecava and pulmonary artery, the pulmonary artery and aorta were clamped and the infusion was stopped.…”
Section: Specimen Preparationmentioning
confidence: 99%
See 1 more Smart Citation
“…Next, the rats were euthanized by a 20 mEq intravenous injection of KCI solution. Heparinized saline (5000 units=100 cm 3 ) and a vasodilator (Lidocaine, 1 mg=kg) were used to ush the vascular system, followed by infusion of microÿl (a silicon polymer containing lead chromate) at 100 mm Hg pressure using a Harvard pump. As soon as the microÿl entered both venaecava and pulmonary artery, the pulmonary artery and aorta were clamped and the infusion was stopped.…”
Section: Specimen Preparationmentioning
confidence: 99%
“…Modern micro-CT scanners can produce very large three-dimensional (3D) digital images of vascular trees [1][2][3][4]. A typical tree consists of hundreds of branches and many generations.…”
Section: Introductionmentioning
confidence: 99%
“…Tissue contrast in the head and brain could be improved if a lower setting were permitted. CT scanners specifically designed for small-animal imaging and operating at lower tube voltages [3] exhibit appreciably higher tissue contrast and could, therefore, potentially yield improved image registration compared to that observed in this work. The MR image contrast might also be improved with a similar effect on registration accuracy.…”
Section: Discussionmentioning
confidence: 76%
“…For these reasons, investigators have developed high resolution imaging systems specifically designed for small animal imaging. 111,112,[118][119][120] These include microCT systems 118,[121][122][123] that incorporate a low power X-ray tube and a phosphor-coupled CCD camera or similar two-dimensional x-ray imaging detector to achieve spatial resolutions as high as 25 microns or better. Similarly, high-resolution images can be obtained using microPET scanners 111,119 having high-resolution detectors operated in coincidence to obtain spatial resolutions in the range of 1 to 2 mm, whereas SPECT imaging of mice [124][125][126][127][128][129] can be performed using pinhole collimation to obtain spatial resolutions better than 1 millimetre.…”
Section: Small-animal Imaging Systemsmentioning
confidence: 99%