A New Xanthone from the Stems of <i>Garcinia Kola</i>

Terashima, Kenji; Kondo, Yoshihito; Aqil, Mohammad; Niwa, Masayuki

doi:10.1080/10575639908041215

Cited by 5 publications

(5 citation statements)

References 14 publications

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“…To our knowledge, there was no previous report on the antimicrobial activities on beta-lactamresistant bacteria or the chemical natures of the potentially antimicrobial compounds of the 12 plant species investigated in the present study. However, some studies revealed the presence of bergapten, coumarin, beta-sitosterol, beta-sitosterol glucopyranoside, oleanolic, naringenic acid, and prorepensin in D. picta [22]; flavonoids and xanthones in G. kola [23,24], cycloartane derivatives, anthocyane, flavonoids, saponins triterpenes and alkaloids in G. lucida [25][26][27], friedelin, taraxerone, epifriedelinol, taraxerol in B. micrantha [28,29], sterols in P. africanus [30]. It is probable that some of these compounds, alone or in combination, are responsible for the observed antimicrobial properties as previously shown.…”

Section: Discussionmentioning

confidence: 99%

The in-vitro antimicrobial activity of some medicinal plants against β-lactam-resistant bacteria

Gangoué-Piéboji

Eze

Djintchui

et al. 2009

J Infect Dev Ctries

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Background: In effort to identify novel bacterial agents, this study was initiated to evaluate the antimicrobial properties of 17 crude extracts from 12 medicinal plants against beta-lactam-resistant bacteria. Methodology: The antimicrobial activities of plant extracts were evaluated against clinically proved beta-lactam-resistant bacteria (Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, Serratia marcescens, Acinetobacter baumannii, Staphylococcus aureus and Enterococcus sp.) and reference strains of bacteria (Escherichia coli ATCC 35218, Enterobacter aerogenes ATCC 29751, E. aerogenes ATCC 13048, Pseudomonas aeruginosa ATCC 27853 and Enterococcus hirae ATCC 9790) by using disc-diffusion and agar-dilution assays. Results: The crude plant extracts demonstrated broad spectrum activity against all bacteria tested with inhibition zones in the range of 8-30 mm. The minimal inhibitory concentration (MIC) values of different plant extracts against the tested bacteria were found to range from ≤ 0.3 to ≥ 10 mg ml -1 . The most active plant extracts were from Dortenia picta and Bridelia micrantha (MIC: 1.25-10 mg ml -1 ) on beta-lactamresistant Gram-negative bacilli and the extracts from B. micrantha, Mallotus oppositifolius, Garcinia lucida, Garcinia. kola, Campylospermum densiflorum (leaves) and C. zenkeri (root) on beta-lactam-resistant Gram-positive cocci (MIC: ≤ 0.3-5 mg ml -1 ). Conclusion: Of the 17 plant extracts studied, seven showed good antimicrobial activity against the tested bacteria. The stem bark of B. micrantha and the leaves of D. picta were most active towards beta-lactamase producing Gram-negative bacilli. This study shows that medicinal plants could be sources of compounds which can be used to fight against beta-lactam resistant bacteria.

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Section: Discussionmentioning

confidence: 99%

The in-vitro antimicrobial activity of some medicinal plants against β-lactam-resistant bacteria

Gangoué-Piéboji

Eze

Djintchui

et al. 2009

J Infect Dev Ctries

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“…The roots were also found to contain cycloartenol ( 17 ) and 24-methylenecycloartenol ( 18 ). Several related xanthone analogues, namely 2-hydroxy-, 4-hydroxy-, 1,5-dihydoxy-, 1,2,8-trihydroxy-, 2-hydroxy-1-methoxy-, 3-hydroxy-4-methoxy-, 1,2-dimethoxy-, 2,5-dihydroxy-1-methoxy-, 2-hydroxy-1,8-dimethoxy-, and 1,3,5-trihydroxy-2-methoxy-xanthone ( 19–28 ) have been detected in the stems (Terashima et al 1999 ). Both the cycloartenol and xanthone derivatives are quite abundant in the plant kingdom (El-Seedi et al 2009 ; Gwatidzo et al 2014 ).…”

Section: Resultsmentioning

confidence: 99%

“…As it is also noted above G. kola also contains quite large number of xanthone derivatives, which are also widely distributed throughout the higher plants. Other xanthone-producing species from the Clusiaceae family include Hypericum , Calophyllum , Kielmeyera and Tovomita (Terashima et al 1999 ). These compounds are attracting a considerable research interest as they (e.g.…”

Section: Resultsmentioning

confidence: 99%

Garcinia kola: a critical review on chemistry and pharmacology of an important West African medicinal plant

et al. 2023

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Garcinia kola Heckel (Clusiaceae) is a tree indigenous to West and Central Africa. All plant parts, but especially the seeds, are of value in local folklore medicine. Garcinia kola is used in treatment of numerous diseases, including gastric disorders, bronchial diseases, fever, malaria and is used to induce a stimulating and aphrodisiac effect. The plant is now attracting considerable interest as a possible source of pharmaceutically important drugs. Several different classes of compounds such as biflavonoids, benzophenones, benzofurans, benzopyran, vitamin E derivatives, xanthones, and phytosterols, have been isolated from G. kola, of which many appears to be found only in this species, such as garcinianin (found in seeds and roots), kolanone (fruit pulp, seeds, roots), gakolanone (stem bark), garcinoic acid, garcinal (both in seeds), garcifuran A and B, and garcipyran (all in roots). They showed a wide range of pharmacological activities (e.g. analgesic, anticancer, antidiabetic, anti-inflammatory, antimalarial, antimicrobial, hepatoprotective and neuroprotective effects), though this has only been confirmed in animal models. Kolaviron is the most studied compound and is perceived by many studies as the active principle of G. kola. However, its research is associated with significant flaws (e.g. too high doses tested, inappropriate positive control). Garcinol has been tested under better conditions and is perhaps showing more promising results and should attract deeper research interest (especially in the area of anticancer, antimicrobial, and neuroprotective activity). Human clinical trials and mechanism-of-action studies must be carried out to verify whether any of the compounds present in G. kola may be used as a lead in the drug development.

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“…There appear to have been no previous reports on the anti-β-lactamase activities, or the chemical natures of the potentially inhibitory compounds of the 16 plant species investigated in the present study. However, some studies revealed the presence of coumarins, flavonoids and xanthones in M. africana (Ouahouo et al, 2004;Gangoué-Piéboji et al, 2006), flavonoids and xanthones in G. kola (Terashima et al, 1999;Iwu et al, 2002), cycloartane derivatives, anthocyane, flavonoids, saponins and triterpenes (Nyemba et al, 1990;Guedje, 2002), friedelin, taraxerone, epifriedelinol, taraxerol in B. micrantha (Pegel and Rogers, 1968;Kouam et al, 2005). It is probable that some of these compounds are responsible for the observed anti β-lactamase activities.…”

Section: Resultsmentioning

confidence: 99%

Screening of some medicinal plants from cameroon for β‐Lactamase inhibitory activity

Gangoué-Piéboji

Baurin

Frère

et al. 2007

Phytotherapy Research

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In efforts to find new bioactive beta-lactamase inhibitors, this study investigated 16 Cameroonian plants belonging to 10 families which were evaluated for anti-beta-lactamase activity. The investigation showed that extracts 2, 6, 3 and 5 of the 16 plants investigated presented interesting in vitro beta-lactamase inhibition (over 90%), respectively, of the beta-lactamases TEM-1, OXA-10, IMP-1 and P99. These extracts were from Mammea africana (all beta-lactamases), Garcinia lucida, G. kola (OXA-10, IMP-1 and P99), Bridelia micrantha (OXA-10, P99), Ochna afzelii (OXA-10, P99), Prunus africana (IMP-1) and Adenia lobata (TEM-1). After elimination of tannins (according to the European Pharmacopoeia) the extracts from B. micrantha, G. lucida and M. africana were tested further for their anti-beta-lactamase activity. The extracts from B. micrantha and G. lucida exhibited potent inhibitory activity, respectively, of beta-lactamase OXA-10 (IC(50) = 0.02 mg/mL) and P99 (IC(50) = 0.01 mg/mL). The anti-beta-lactamase activity of M. africana extract was weak. The isolation and the structural elucidation of the active constituents of G. lucida and B. micrantha will provide useful leads in the development of beta-lactamase inhibitors.

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A New Xanthone from the Stems of Garcinia Kola

Cited by 5 publications

References 14 publications

The in-vitro antimicrobial activity of some medicinal plants against β-lactam-resistant bacteria

The in-vitro antimicrobial activity of some medicinal plants against β-lactam-resistant bacteria

Garcinia kola: a critical review on chemistry and pharmacology of an important West African medicinal plant

Screening of some medicinal plants from cameroon for β‐Lactamase inhibitory activity

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