A Nickel-Containing Polyoxomolybdate as an Efficient Antibacterial Agent for Water Treatment

Abstract

In view of the water pollution issues caused by pathogenic microorganisms and harmful organic contaminants, nontoxic, environmentally friendly, and efficient antimicrobial agents are urgently required. Herein, a nickel-based Keggin polyoxomolybdate [Ni(L)(HL)]2H[PMo12O40] 4H2O (1, HL = 2-acetylpyrazine thiosemicarbazone) was prepared via a facile hydrothermal method and successfully characterized. Compound 1 exhibited high stability in a wide range of pH values from 4 to 10. 1 demonstrated significant antibacterial activity, with minimum inhibitory concentration (MIC) values in the range of 0.0019–0.2400 µg/mL against four types of bacteria, including Staphylococcus aureus (S. aureus), Bacillus subtilis (B. subtilis), Escherichia coli (E. coli), and Agrobacterium tumefaciens (A. tumefaciens). Further time-kill studies indicated that 1 killed almost all (99.9%) of E. coli and S. aureus. Meanwhile, the possible antibacterial mechanism was explored, and the results indicate that the antibacterial properties of 1 originate from the synergistic effect between [Ni(L)(HL)]+ and [PMo12O40]3−. In addition, 1 presented effective adsorption of basic fuchsin (BF) dyes. The kinetic data fitted a pseudo-second-order kinetic model well, and the maximum adsorption efficiency for the BF dyes (29.81 mg/g) was determined by the data fit of the Freundlich isotherm model. The results show that BF adsorption was dominated by both chemical adsorption and multilayer adsorption. This work provides evidence that 1 has potential to effectively remove dyes and pathogenic bacteria from wastewater.

Zeolitic imidazolate framework-8 encapsulated with Mo-based polyoxometalates as surfaces with antibacterial activity against Escherichia coli

“…26,28,29 Additionally, they can decrease the reduced glutathione pole, sensitizing the bacterial cells to oxidative stress. 26,29,63 The observed synergism between PMA and ZIF-8 can be attributed to their distinct but complementary abilities to target multiple mechanisms. Hence, further research is needed to explore the potential bacterial protein targets of PMA@ZIF-8, which could shed light on the specic molecular pathways involved in its enhanced antibacterial activity.…”

“…26,27 POMs are water-soluble agents, that can cause their antibacterial activity by penetration of the outer membrane, 27,28 causing oxidation of different electron carriers (e.g., NADH), leading to paralysis of the bacterial respiratory chain. 26,29 POMs are also strong oxidizing agents which can create ROS. 26,29 The recent literature has extensively studied the PMA and ZIF-8 antimicrobial properties, 14,26 yet their combined synergistic effect has not been reported.…”

Large Ultrathin Polyoxomolybdate-Decorated Boron Nitride Nanosheets with Enhanced Antibacterial Activity for Infection Control

“…15,16 Several POMs, especially polyoxomolybdates, have recognizable antibacterial activity against both Gramnegative and Gram-positive bacteria, depending on their composition, morphology, and size. 17,18 Ammonium molybdate, a kind of polyoxometalate, can be regarded as a watersoluble metal oxide with an oxygen-rich surface, whose structure, composition, and charge properties can be adjusted. 19 However, the excellent water solubility of POMs limits their processability and leads to leaching concerns during applications.…”

“…Polyoxometalates (POMs) are unique polyanionic clusters composed of early transition metal ions bridged by oxygen atoms, which are considered promising metallodrugs due to their wide range of tunable structures and biological effects . In particular, POMs have demonstrated surprising biological advantages in the treatment of infections associated with bacteria, which exert antibacterial activity through penetration. , Several POMs, especially polyoxomolybdates, have recognizable antibacterial activity against both Gram-negative and Gram-positive bacteria, depending on their composition, morphology, and size. , Ammonium molybdate, a kind of polyoxometalate, can be regarded as a water-soluble metal oxide with an oxygen-rich surface, whose structure, composition, and charge properties can be adjusted . However, the excellent water solubility of POMs limits their processability and leads to leaching concerns during applications.…”

Nanomaterials as carriers to improve the photodynamic antibacterial therapy

“…To this day, antibiotics are still used for the treatment of various bacterial infectious diseases. However, due to the widespread use of antibiotics and the rapid mutation of bacteria, the emergence of bacterial resistance has exposed the limitations of antibiotic application (Ma et al, 2018;Mil-Homens et al, 2021;Chang et al, 2022;Chawla et al, 2022). Routinely developed new antibacterial drugs, due to their single target, cannot alleviate the generation of bacterial resistance, and will lead to a decrease in the antibacterial efficiency of the drug over time (Xu and Yang, 2020).…”