A nomogram for rate correction of the Q-T interval in the electrocardiogram

Kissin, Milton; Schwarzschild, Myron M.; Bakst, Hyman

doi:10.1016/0002-8703(48)90598-5

Cited by 60 publications

(13 citation statements)

References 3 publications

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“…On the lead II rhythm strip the QT interval was measured for 3-5 consecutive heart beats, corrected for heart rate using the nomogram of Kissin et al [12] and averaged for each reinfusion cycle.…”

Section: Methodsmentioning

confidence: 99%

Laboratory and Clinical Effects of the Infusion of ACD Solution During Plateletpheresis

Olson¹,

Cox²,

McCullough³

1977

Vox Sanguinis

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Transfusion of massive amounts of citrate anticoagulated blood during plateletpheresis with the intermittent flow centrifuge can produce symptoms and electrocardiographic changes suggestive of hypocalcemia. Following 15 procedures the ionized calcium decreased by an average of 32.4%, the average postpheresis serum citrate was 26.7 mg/dl and the QT interval was prolonged by 0.08 sec. Twelve plateletphereses performed with half-strength ACD solution caused an average decrease in ionized calcium of 16%, serum citrate levels of 12.5 mg/dl and QT prolongation of 0.04 sec. No donors experienced significant clinical symptoms with citrate infusion rates of less than 65 mg/kg/h. Solutions with citrate concentrations lower than ACD-A should be developed for use in plateletpheresis procedures involving citrate infusion rates greater than this.

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Section: Methodsmentioning

confidence: 99%

Laboratory and Clinical Effects of the Infusion of ACD Solution During Plateletpheresis

Olson¹,

Cox²,

McCullough³

1977

Vox Sanguinis

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“…In 16 chronic schizophrenic patients on fluphenazine decanoate (proportion of females and age not given), ECG abnormalities occurred in 31%, one of them showing a QT prolongation > 400 ms (Turbott et al, 1987). The study used a nomogram (Kissin et al, 1948) for rate correction of the QT interval.…”

Section: Fluphenazinementioning

confidence: 99%

Antipsychotic drugs and QT prolongation

Stöllberger¹,

Huber²,

Finsterer

2005

International Clinical Psychopharmacology

152

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Antipsychotic drugs (AD) are effective and frequently prescribed to more females than males. AD may cause serious cardiovascular side-effects, including prolonged QT interval, eventually leading to torsades de pointes (TdP) and sudden death. Epidemiologic data and case-control studies indicate an increased rate of sudden death in psychiatric patients taking AD. This review summarizes current knowledge about the QT prolonging effects of AD and gives practical suggestions. Amisulpride, clozapine, flupenthixol, fluphenazine, haloperidol, melperone, olanzapine, perphenazine, pimozide, quetiapine, risperidone, sulpiride, thioridazine and ziprasidone cause a QT prolongation ranging from 4 ms for risperidone to 30 ms for thioridazine. Our knowledge about the QT-prolonging effects of many AD is still limited. Females are under-represented in most studies. Many studies were conducted or supported by pharmaceutical companies. To avoid prodysrhythmia caused by QT prolongation, other factors influencing QT interval have to be considered, such as other drugs affecting the same pathway, hypokalemia, hypomagnesemia, bradycardia, increased age, female sex, congestive heart failure and polymorphisms of genes coding ion channels or enzymes involved in drug metabolism. Because the response of a patient to AD is individual, an electrocardiogram recording the QT interval has to be performed at baseline, after AD introduction and after occurrence of any factor that might influence the QT interval.

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“…Any such minor differences are also nullified by the fact that there were approximately equal numbers of females in the two groups. The corresponding mean heart rate was similarly calculated and the rate-corrected QT (QTc) was read off from the nomogram of Kissin et al (1948).…”

Section: Rate-corrected Qt (Qtc) Estimations From Ecg Recordingsmentioning

confidence: 99%

Blood quinidine levels and cardiac effects in white British and Nigerian subjects.

Olatunde¹,

Da²

1982

Brit J Clinical Pharma

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1 Differences between whites and blacks have been described in the incidence and patterns of cardiac disease and in electrocardiographic features. 2 The objective of the present study was to see if the ECG response to the same plasma and red blood cell quinidine concentration differed between whites and blacks. 3 It was found that following a standard single oral dose of quinidine both plasma and red blood cell quinidine concentrations tended to be lower in seven healthy white British subjects than in seven healthy Nigerians. 4 The change in QTc interval (delta QTc) after quinidine, however, tended to be greater in the white British subjects than in the Nigerians. 5 At a single plasma quinidine concentration the delta QTc tended to be higher in white British subjects than in Nigerians. 6 At a single blood cell quinidine concentration, delta QTc was significantly higher in British white subjects than in Nigerians. 7 The inter‐ethnic differences found could be due to both environmental and genetic factors. Further work will be required to decide the relative importance of both these factors on plasma quinidine levels and QTc responses.

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A nomogram for rate correction of the Q-T interval in the electrocardiogram

Cited by 60 publications

References 3 publications

Laboratory and Clinical Effects of the Infusion of ACD Solution During Plateletpheresis

Laboratory and Clinical Effects of the Infusion of ACD Solution During Plateletpheresis

Antipsychotic drugs and QT prolongation

Blood quinidine levels and cardiac effects in white British and Nigerian subjects.

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