A non‐linear asymmetric error function‐based least mean square approach for the analysis of multicomponent mass spectra measured by membrane inlet mass spectrometry

Ketola, Raimo A.; Ojala, Marja; Komppa, Veikko; Kotiaho, Tapio; Juujärvi, Jouni; Heikkonen, Jukka

doi:10.1002/(sici)1097-0231(19990430)13:8<654::aid-rcm537>3.3.co;2-9

Cited by 12 publications

(20 citation statements)

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“…2, the non‐unit resolution of the Micropole analyzer makes it very difficult to analyze multicomponent air samples. Using the Omnistar mass spectrometer, isotopic peaks are nicely separated and analysis of multicomponent mixtures is possible 22. Figure 3 shows that the repeatability of the Omnistar mass spectrometer is rather better than that of the Micropole instrument.…”

Section: Performance Characteristics Of the Micropole Analyzer And Thmentioning

confidence: 99%

Comparison of analytical performances of a micro‐array quadrupole instrument and a conventional quadrupole mass spectrometer equipped with membrane inlets

Ketola

Kiuru

Tarkiainen

et al. 2003

Rapid Comm Mass Spectrometry

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Section: Performance Characteristics Of the Micropole Analyzer And Thmentioning

confidence: 99%

Comparison of analytical performances of a micro‐array quadrupole instrument and a conventional quadrupole mass spectrometer equipped with membrane inlets

Ketola

Kiuru

Tarkiainen

et al. 2003

Rapid Comm Mass Spectrometry

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“…Previous researchers employing residual gas analysis to study gas mixtures used mathematical methods such as function‐based least mean square regression, parallel factor analysis or the use of an internal standard . However, this approach can be problematic as Turner et al .…”

Section: Resultsmentioning

confidence: 99%

Study of solid/gas phase photocatalytic reactions by electron ionization mass spectrometry

2014

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This paper describes a novel methodology for the real-time study of solid-gas phase photocatalytic reactions in situ. A novel reaction chamber has been designed and developed to facilitate the investigation of photoactive materials under different gas compositions. UV irradiation in the wavelength of ranges 376-387 and 381-392 nm was provided using specially designed high efficiency light emitting diode arrays. The experiments used air containing 190 ppm NO2 in a moist environment with a relative humidity of 0.1%. Photocatalytic samples consisting of pressed pellets of rutile and anatase crystalline forms of TiO2 were monitored over a period of 150 min. An ultra-high vacuum right angled bleed valve allowed a controlled flow of gas from the main reaction chamber at atmospheric pressure to a residual gas analyser operating at a vacuum of 10(-5) mbar. The apparatus and methodology have been demonstrated to provide high sensitivity (ppb). The rate of degradation of NO2 attributed to reaction at the TiO2 surface was sensitive to both crystal structures (anatase or rutile) and wavelength of irradiation.

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“…The individual VOCs can be identified from the electron ionization PAM mass spectra (Fig. 2) by using the custom‐made Solver software 18. In this study the PAM‐MS method combined with the Solver software was compared with a P&T‐GC/MS method in identification of VOCs from two different pharmaceutical products.…”

Section: Resultsmentioning

confidence: 99%

Analysis of residual solvents in pharmaceuticals with purge-and-membrane mass spectrometry

Ojala

Poutanen

Mattila

et al. 2000

Rapid Commun. Mass Spectrom.

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A method using purge-and-membrane mass spectrometry (PAM-MS) was developed for the analysis of residual solvents in pharmaceutical products. The method combines dynamic headspace and membrane inlet mass spectrometry. The limits of detection for the compounds studied, benzene, toluene, chloroform, 2-pentene and 2-methyl- and 3-methylpentane, were 0.05-0.1 mg/kg. In quantitative analysis the method showed good linearity (r(2) > 0.998) and acceptable within-day (RSD = 7.9-18%) and between-day (RSD = 6.8-10%) repeatability. The PAM-MS method combined with the custom-made Solver program was compared with a method using purge-and-trap gas chromatography/mass spectrometry (P&T-GC/MS) for identification of residual solvents from authentic samples. The results showed that PAM-MS/Solver provides reliable identification of the main volatile organic compounds (VOCs) in the pharmaceuticals, but VOCs with low concentrations (below 0.5 mg/kg) were better identified by P&T-GC/MS. Other advantages of the PAM-MS method were short analysis times and non-requirement for pre-treatment of samples.

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A non‐linear asymmetric error function‐based least mean square approach for the analysis of multicomponent mass spectra measured by membrane inlet mass spectrometry

Cited by 12 publications

References 0 publications

Comparison of analytical performances of a micro‐array quadrupole instrument and a conventional quadrupole mass spectrometer equipped with membrane inlets

Comparison of analytical performances of a micro‐array quadrupole instrument and a conventional quadrupole mass spectrometer equipped with membrane inlets

Study of solid/gas phase photocatalytic reactions by electron ionization mass spectrometry

Analysis of residual solvents in pharmaceuticals with purge-and-membrane mass spectrometry

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