A non‐parametric method for the comparison of partial areas under ROC curves and its application to large health care data sets

Zhang, Dong D.; Zhou, Xia; Freeman, Daniel; Freeman, Jean L.

doi:10.1002/sim.1011

Cited by 117 publications

(61 citation statements)

References 30 publications

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“…Univariate and multivariate statistical analyses were performed to determine the significance of various factors using the Kaplan-Meier method and log-rank test [16]. P -values < 0.05 were considered statistically significant.…”

Section: Methodsmentioning

confidence: 99%

Long-term follow-up of papillary and follicular thyroid carcinomas with bone metastasis

Lin

Chen

et al. 2017

PLoS ONE

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The aims of this study were to investigate papillary and follicular thyroid carcinomas with bone metastasis in various clinical presentations and to determine the prognostic factors after multimodality treatment. A retrospective analysis was performed of 3,120 patients with papillary and follicular thyroid carcinoma. Of these patients, 131 (including 97 women, 71.8%) were diagnosed with bone metastasis and underwent follow-up at the Chang Gung Medical Center. Patients with bone metastasis were categorized into two groups. Group A was comprised of patients who were diagnosed with bone metastasis either before thyroidectomy or within 6 months of the initial thyroidectomy (90 patients, 68.7%). Group B was comprised of patients with bone metastasis who received a diagnosis 6 months post-thyroidectomy in the follow-up period (41 patients, 31.3%). After a mean follow-up period of 8.4 ± 7.0 years, there were 88 deaths (67.2%) attributed to thyroid cancer and 13 patients (9.9%) achieved disease-free status. A multivariate analysis showed that older age, early diagnosis, and brain metastasis were each associated with a poor prognosis. The difference in disease-specific mortality rates between groups A and B was significant (p < 0.0001). In conclusion, papillary and follicular thyroid cancers with bone metastasis have a high rate of mortality. Despite this high mortality, 9.9% patients still had an excellent response to treatment.

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Section: Methodsmentioning

confidence: 99%

Long-term follow-up of papillary and follicular thyroid carcinomas with bone metastasis

Lin

Chen

et al. 2017

PLoS ONE

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“…Cancer-related mortality was calculated, and the follow-up period was determined from the date of diagnosis to the date of cancer-related mortality of the last survivor undergoing follow-up care. Survival rates were calculated using the Kaplan-Meier method and compared using a log-rank test [12]. A multivariate Cox proportional hazard regression model was used to estimate the mortality risk.…”

Section: Methodsmentioning

confidence: 99%

Therapeutic Outcomes of Patients with Multifocal Papillary Thyroid Microcarcinomas and Larger Tumors

Kuo

Chen

et al. 2017

International Journal of Endocrinology

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A retrospective review of 626 patients with multifocal papillary thyroid carcinoma (PTC) including 147 patients (23.5%) with multifocal papillary thyroid microcarcinoma (PTMC) from a total of 2,536 patients with PTC who visited the Chang Gung Medical Center in Linkou, Taiwan, was performed. A comparison of the clinical features between 626 multifocal and 1,910 solitary PTC cases showed that patients in the multifocal PTC group were older and had a smaller mean tumor size, a more advanced tumor-node-metastasis (TNM) stage, and a higher percentage of nonremission status compared to patients in the solitary PTC group. Of the 626 patients with multifocal PTC, the group with larger tumors showed a more advanced TNM stage, a higher percentage of lymph node metastasis and soft tissue invasion, and a higher nonremission rate compared to the multifocal PTMC group. Of the 626 patients with multifocal PTC, 25 patients (4%) died during a mean follow-up period of 7.1 ± 5.3 years. Kaplan-Meier survival curves showed a significantly lower survival rate associated with multifocal PTMC compared to that with solitary PTMC.

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“…All of the data were expressed as means ± standard error of the mean. A univariate statistical analysis was performed to determine the significance of various factors using the Kaplan-Meier method and a logrank test [14]. p < 0.05 was considered statistically significant.…”

Section: Methodsmentioning

confidence: 99%

Therapeutic Outcomes of Papillary Thyroid Cancer Patients in Different Risk Groups

Huang¹,

Lin²,

Chao³

et al. 2011

Oncology

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Objective: The objective of this study was to determine the therapeutic outcome of papillary thyroid cancer (PTC) patients in different risk groups in one institute. Methods: A total of 1,759 PTC patients were categorized into low- (n = 1,123), intermediate- (n = 75), and high-risk (n = 561) groups according to tumor-node-metastasis (TNM) stage. Results: Of the patients, 15.1% presented with lymph node metastases, and 4.6% presented with distant metastases at the time of thyroid operation. After 8.0 ± 0.1 years of follow-up, 73 (4.2%) patients died of thyroid cancer. Tumor size, local invasion, and lymph node metastases adversely influenced recurrence and survival. Of the patients in the 3 groups, 9 (0.8%), 8 (10.7%), and 56 (10.0%) died of thyroid cancer, respectively. In addition, 88 (7.8%), 14 (18.7%), and 144 (25.8%) patients showed recurrence during the follow-up period. Patients with highly aggressive histological patterns showed increased recurrence and cancer mortality compared with the low-risk group; otherwise, values were not higher than those of the high-risk group. Conclusions: The cancer-related mortality was nearly 10% in the intermediate- and high-risk groups, and the patients in these groups required aggressive surgical and postoperative adjuvant therapies.

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A non‐parametric method for the comparison of partial areas under ROC curves and its application to large health care data sets

Cited by 117 publications

References 30 publications

Long-term follow-up of papillary and follicular thyroid carcinomas with bone metastasis

Long-term follow-up of papillary and follicular thyroid carcinomas with bone metastasis

Therapeutic Outcomes of Patients with Multifocal Papillary Thyroid Microcarcinomas and Larger Tumors

Therapeutic Outcomes of Papillary Thyroid Cancer Patients in Different Risk Groups

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