A notable impact of lipid matrices on cholesterol bioaccessibility from phytosterols-loaded nanostructured lipid carriers during in vitro intestinal digestion

Guo, Shujing; Ma, Cheng; Hu, Yuyuan; Song, Zhen-Jia; Wang, Tong; Yang, Ruinan

doi:10.1016/j.fbio.2023.102500

Cited by 4 publications

(4 citation statements)

References 40 publications

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“…This means that the size of particles observed by TEM is smaller than that determined by DLS technology. This result was consistent with most studies attributed to the differences in technique or discrepancies arising from sample pre‐treatment 5,32 . After freeze‐drying, the spherical nanoparticles gradually aggregate to form tightly packed structures due to water loss.…”

Section: Resultssupporting

confidence: 90%

“…This result was consistent with most studies attributed to the differences in technique or discrepancies arising from sample pre-treatment. 5,32 After freeze-drying, the spherical nanoparticles gradually aggregate to form tightly packed structures due to water loss. The SEM images of PNP and CS-PNP are shown in Fig.…”

Section: Microstructure Of Nanoparticlesmentioning

confidence: 99%

“…Numerous studies have shown that the intake of PS effectively reduces cholesterol levels in the body. [2][3][4][5] It is of great importance for the prevention of cardiovascular and cerebrovascular diseases. The daily intake of PS varies considerably between dietary environments from 150 to 500 mg d −1 .…”

Section: Introductionmentioning

confidence: 99%

“…Their structure is similar to that of cholesterol, with the difference lying in the double bonds and methyl groups in their branched chains. Numerous studies have shown that the intake of PS effectively reduces cholesterol levels in the body 2‐5 . It is of great importance for the prevention of cardiovascular and cerebrovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

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Chitosan‐coated soybean protein isolate/lecithin nanoparticles for enhancing the stability and bioaccessibility of phytosterol

Cheng,

Tao,

Wang

et al. 2024

J Sci Food Agric

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BACKGROUNDPhytosterols (PS) have various beneficial effects on human health, especially the property of reducing blood cholesterol. However, the low solubility and bioaccessibility of PS have greatly limited their application in functional food ingredients.RESULTSTo improve the bioaccessibility and stability of PS, chitosan‐coated PS nanoparticles (CS‐PNP) were successfully prepared by self‐assembly. The properties of CS‐PNP, including size, zeta potential, encapsulation efficiency (EE) and loading amount (LA) were characterised. The optimisation of CS concentration (0.4 mg mL−1) and pH (3.5) resulted in the formation of CS‐PNP with an EE of over 90% and a particle size of 187.7 nm. Due to the special properties of CS chitosan, the interaction between CS and soybean protein isolate (SPI)/lecithin (SL) led to the formation of a soluble complex. CS‐PNP exhibited good stability to temperature variations but was more sensitive to salt ions. During in vitro digestion, CS efficiently maintained the stability of nanoparticles against the hydrolysis of SPI by pepsin under acidic conditions. However, these nanoparticles tended to aggregate in a neutral intestinal environment. After 3 h of in vitro digestion, the bioaccessibility of PS increased from 18.2% of free PS to 63.5% of CS‐PNP.CONCLUSIONOverall, these results highlight the potential of chitosan‐coated nanoparticles as effective carriers for the oral administration of PS. This multilayer construction may serve as a promising for applications in food products as delivery vehicles for nutraceuticals. © 2024 Society of Chemical Industry.

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Section: Resultssupporting

confidence: 90%

Section: Microstructure Of Nanoparticlesmentioning

confidence: 99%