A Note on Regulatory Concerns and Toxicity Assessment in Lipid-Based Delivery Systems (LDS)

Abstract

Lipid-based Delivery Systems (LDS) has been the focus of potential strategies in drug delivery for several years. A great deal of work has been invested on how to exploit their biocompatible and biodegradable nature, in combination with their nanosize range in a profitable way in the field of nanomedicines. A number of drugs loaded in LDS have been already tested in vivo successfully. However, in vivo behaviour of nanosized materials differs from their bulk counterparts (and also change drug properties), mainly depending on the particular LDS physicochemical characteristics. These may have huge impact on the toxicity of the system, despite the physiological nature of the lipid materials. This note on the regulatory concerns and toxicity assessment in LDS suggests that current knowledge of public and scientific communities is lacking, requiring intensive research and policy measures to provide a deep understanding on toxicological risks.

Preparation and Release Characteristic of Quercetin Loaded Poly(lactic acid) Ultrafine Fibers

“…[12][13][14][15] For the large surface area and microporous structure of ultrafine materials and nanomaterials, they have been widely applied as drug carrier or tissue engineering scaffold. [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] The large length-diameter ratio characteristic of the ultrafine fibers and nanofibers made them getting much attention in drug delivery field. [16][17] And electrospinning is one of the methods which have been widely used for preparing the ultrafine fibers.…”

Preparation, Characterization, and<I> In Vitro</I> Evaluation of Docetaxel-Loaded Poly(lactic acid)-Poly(ethylene glycol) Nanoparticles for Parenteral Drug Delivery

“…9 Nanoparticles offer an alternative delivery system for cancer therapy that have the potential to control the release rate of drug, improve the drug solubility, pharmacokinetics and biodistribution, and reduce drug side effects. [10][11][12][13][14] Due to their small size, nanoparticles with entrapped drugs may penetrate tumors due to the discontinuous and leaky nature of the microvasculature of tumors. [15][16] Also, the characteristically poor lymphatic drainage of tumors may result in slower clearance of nanoparticles that accumulate in tumors.…”

The real value of novel particulate carriers for sunscreen formulation

“…In the specific case of sunscreen encapsulation, the largest body of literature concerns the use of lipids (e.g., mono-, di-and triglycerides, fatty acids, waxes) to embed chemical UV filters with the already mentioned goals: increasing stability, reducing release from the final formulation and overcoming solubility issues during formulation [1]. The choice of lipids as wall material derives from their common use in pharmaceutical and cosmetic dermal formulations, their regulatory status and the physicochemical characteristics (i.e., lipophilicity) of the majority of molecular UV absorbers [68]. Solid lipid microparticles (SLMs) or lipospheres as carrier for sunscreens will be discussed later, while UV filter embedded in SLMs [69,70] have been examined elsewhere in this For personal use only.…”