Multiple-agent scheduling has attracted considerable research attention in recent years. However, studies of multiple-agent scheduling with release times and deadlines are few. In the presence of ready times, sometimes it is beneficial to wait for future job arrivals in constructing a schedule. Inspired by the importance of ready times, we study the single-machine two-agent scheduling problem with releases times and deadlines to minimise the number of tardy jobs of one agent under the restriction that the maximum lateness of the jobs of the other agent cannot exceed a given value Q. Having established that the problem is strongly NP-hard, we provide a branch-and-bound and a simulated annealing algorithm to search for the optimal and approximate solutions, respectively. The results of computational experiments reveal that the SA algorithm can generate near-optimal solutions quickly.Keywords: scheduling; two agents; simulated annealing; release times.Reference to this paper should be made as follows: Yin, Y., Cheng, S-R., Cheng, T.C.E., Wu, W-H. and Wu, C-C. (2013) . His research covers semi-group theory, ring theory, module theory and their applications, and algebraic hyper-structure theory, fuzzy sets, rough sets and process scheduling. He has published more than 70 papers in these fields and written a book on fuzzy hemi-rings.