A Noteworthy Case Report of Neuroborreliosis in an Unvaccinated Pediatric Patient

Walker, Amber R; Morales-Yurick, Teresita

doi:10.5811/cpcem.2020.9.48688

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…Należy go podejrzewać gdy występuje klasyczna dla tego zespołu triada objawów: 1) bolesna radikulopatia, 2) neuropatia czaszkowa, 3) pleocytoza limfocytarna płynu mózgowo-rdzeniowego oraz pacjent pochodzi z terenu endemicznego dla boreliozy [29]. Opisano również przypadki rzadszych manifestacji neuroboreliozy u dzieci jako: zapalenie wielu nerwów czaszkowych [30,31] i obwodowych [32], zapalenie rdzenia kręgowego [33,34,35,36], zapalenie naczyń mózgowych [37,38,39]. Konsekwencją zapalenia naczyń mózgowych spowodowanego zakażeniem B burgdorferi może być powstanie tętniaków wewnątrzczaszkowych [39,40].…”

Section: Inne Manifestacje Kliniczne Neuroboreliozy U Dzieciunclassified

Clinical manifestations of neuroborreliosis in children – review of literature

Dominika

BIEŃKO

Justyna

et al. 2023

J Educ Health Sport

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Introduction: The most common tick-borne disease caused by the spirochete Borrelia burgdorferi is Lyme disease. It is characterized by a variety of disorders: dermatological, rheumatological, cardiological and neurological. Neuroborreliosis is defined as an involvement of the nervous system, and it is the second most common form of infection in children (10-15% of those infected). The aim of the study: To review the available materials and presentation of the current state of knowledge on the various manifestations of neuroborreliosis in children. Material and method: Databases such as PubMed and Google Scholar were searched. Literature was searched using the keywords: Lyme disease, neuroborreliosis, borreliosis, facial nerve paralysis, and pediatric population. The materials obtained in this way were analyzed in terms of compliance with the subject of the work. Results: Typical clinical manifestations of neuroborreliosis in children are facial nerve palsy and meningitis. Neuroborreliosis is the cause of 50% of all cases of bilateral facial nerve palsy in children. Multiple cranial and peripheral neuritis, myelitis, cerebral vasculitis and, consequently, the formation of intracranial aneurysms are less common manifestations of infection. Conclusions: The symptoms of neuroborreliosis are non-specific. This makes it difficult to make an accurate diagnosis. Even if no information on tick bite or erythema migrans has been obtained from the clinical history, neuroborreliosis should be considered in the differential diagnosis, especially in Lyme-endemic areas.

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Section: Inne Manifestacje Kliniczne Neuroboreliozy U Dzieciunclassified

Clinical manifestations of neuroborreliosis in children – review of literature

Dominika

BIEŃKO

Justyna

et al. 2023

J Educ Health Sport

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“…11 Table 1 lists the pediatric studies and case reports of BWS or if "radiculopathy" was one of the presenting symptoms. 7,[11][12][13][14][15][16][17] BWS have not been reported in other pediatric studies. [6][7][8][9][10]18 In a study of 77 adults with BWS in Europe, the most frequent signs and symptoms included radicular pain (100%), EM (59.7%), headache (46.8%), fatigue (44.2%), malaise (39%), paresthesias (32.5%), FNP (36.4%), meningeal signs (19.5%) and paresis (7.8%).…”

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Bannwarth Syndrome

Dutta

Hunter

Vallejo

2021

Pediatric Infectious Disease Journal

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Lymphocytic meningoradiculitis (Bannwarth syndrome) is a rare manifestation of Lyme neuroborreliosis in children. It is the most common clinical manifestation of early Lyme neuroborreliosis in adults in European countries where the disease is endemic but is rare in children. We report an imported case of Bannwarth syndrome in a pediatric patient and review the literature for other pediatric cases reported.

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Lyme Neuroborreliosis: Mechanisms of B. burgdorferi Infection of the Nervous System

Ford

Tufts

2021

Brain Sciences

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Lyme borreliosis is the most prevalent tick-borne disease in the United States, infecting ~476,000 people annually. Borrelia spp. spirochetal bacteria are the causative agents of Lyme disease in humans and are transmitted by Ixodes spp ticks. Clinical manifestations vary depending on which Borrelia genospecies infects the patient and may be a consequence of distinct organotropism between species. In the US, B. burgdorferi sensu stricto is the most commonly reported genospecies and infection can manifest as mild to severe symptoms. Different genotypes of B. burgdorferi sensu stricto may be responsible for causing varying degrees of clinical manifestations. While the majority of Lyme borreliae-infected patients fully recover with antibiotic treatment, approximately 15% of infected individuals experience long-term neurological and psychological symptoms that are unresponsive to antibiotics. Currently, long-term antibiotic treatment remains the only FDA-approved option for those suffering from these chronic effects. Here, we discuss the current knowledge pertaining to B. burgdorferi sensu stricto infection in the central nervous system (CNS), termed Lyme neuroborreliosis (LNB), within North America and specifically the United States. We explore the molecular mechanisms of spirochete entry into the brain and the role B. burgdorferi sensu stricto genotypes play in CNS infectivity. Understanding infectivity can provide therapeutic targets for LNB treatment and offer public health understanding of the B. burgdorferi sensu stricto genotypes that cause long-lasting symptoms.

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A Noteworthy Case Report of Neuroborreliosis in an Unvaccinated Pediatric Patient

Cited by 3 publications

References 12 publications

Clinical manifestations of neuroborreliosis in children – review of literature

Clinical manifestations of neuroborreliosis in children – review of literature

Bannwarth Syndrome

Lyme Neuroborreliosis: Mechanisms of B. burgdorferi Infection of the Nervous System

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