In this article, an adaptive neural network control system is proposed for a quarter car electrohydraulic active suspension system coping with dynamic nonlinearities and uncertainties. The proposed control system is primarily designed to stabilize a sprung mass position of the quarter car electrohydraulic active suspension. Linear controllers such as the proportional–integral–differential controller have limited control performances. The limited control performances are caused by dynamic phenomena such as nonlinearity, parametric uncertainties, and stiff external disturbances. To overcome these dynamic phenomena, we propose a combined adaptive radial basis function neural network with a backstepping control system for a quarter car active suspension system. This setup can handle the unmatched model uncertainty of the system, while the adaptive neural network can take care of its unknown smoothing functions. In general, radial basis function neural network can represent a complicated function, and therefore, semi-strict-feedback dynamic systems are considered to simplify the adaptive neural network control design. Simulation results are indicated to illustrate adaptive neural network control effectiveness.