A novel adipocytokine, omentin, inhibits platelet-derived growth factor-BB-induced vascular smooth muscle cell migration through antioxidative mechanism

Kazama, Kyosuke; Okada, Muneyoshi; Yamawaki, Hideyuki

doi:10.1152/ajpheart.00048.2014

Cited by 44 publications

(25 citation statements)

References 25 publications

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“…Omentin suppresses growth of vascular smooth muscle cells through an AMPK-dependent mechanism. Omentin also inhibits growth factor-induced smooth muscle cell migration through the anti-oxidative mechanism 79) . More recently, we have shown that omentin attenuates atherosclerotic lesion formation in a mouse model of atherosclerosis 80) .…”

Section: Resultsmentioning

confidence: 99%

Adipocytokines in Cardiovascular and Metabolic Diseases

Ouchi

2016

JAT

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Obesity, particularly excess visceral fat accumulation, is highly associated with the development of metabolic syndrome and atherosclerotic cardiovascular disease. Adipose tissue produces a variety of secreted proteins, referred to as adipocytokines, which directly affect nearby or remote organs. Dysregulation of adipocytokines caused by obese conditions contributes to the pathogenesis of various metabolic and cardiovascular disorders. This review focuses on the significance of several adipocytokines that potentially exert beneficial actions on obesity-related diseases, including atherosclerosis and ischemic heart disease.J Atheroscler Thromb, 2016; 23: 645-654.

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Section: Resultsmentioning

confidence: 99%

Adipocytokines in Cardiovascular and Metabolic Diseases

Ouchi

2016

JAT

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“…In vSMC, omentin inhibits TNF-ainduced expression of vascular cell adhesion molecule 1 and platelet-derived growth factor BB-induced migration through antioxidant mechanism. 19,20 Thus, omentin is an anti-inflammatory adipokine with a potent vasodilatory effect.…”

Section: Introductionmentioning

confidence: 99%

Serum omentin levels: A possible contribution to vascular involvement in patients with systemic sclerosis

Miura

Asano

Saigusa

et al. 2015

The Journal of Dermatology

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Adipokines have been shown to be potentially involved in various pathological processes of systemic sclerosis (SSc), including inflammation, vasculopathy and fibrosis, through their pleiotropic effects. Omentin is a member of the adipokines, and has a protective effect against vascular inflammation and pathological remodeling leading to atherosclerosis as well as a vasodilatory effect. To assess the potential role of omentin in the development of SSc, we determined serum omentin levels by enzyme-linked immunosorbent assay in 66 SSc and 21 control subjects and evaluated their clinical correlation. Serum omentin levels were significantly decreased in diffuse cutaneous SSc patients compared with limited cutaneous SSc patients, while comparable between total SSc patients and healthy controls. In diffuse cutaneous (dc)SSc, patients with a disease duration of 5 years or less had serum omentin levels significantly lower than those with a disease duration of more than 5 years. In total SSc, serum omentin levels were significantly higher in patients with elevated right ventricular systolic pressure than in the others, while serum omentin levels did not correlate with fibrotic and systemic inflammatory parameters. These results suggest that a loss of omentin-dependent protection against vascular inflammation and remodeling may be related to pathological vascular events of early dcSSc. The elevation of serum omentin levels may serve as a marker of vascular involvement leading to pulmonary arterial hypertension in SSc, which is possibly due to the compensatory induction of omentin against the increased pulmonary vascular tone.

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“…Serum omentin-1 concentrations were markedly reduced in patients with type 2 diabetes [7]. Omentin inhibited platelet-derived growth factor BB-induced vascular smooth muscle cell migration by reducing oxidative stress [18]. This indicates that omentin-1 may serve as a target for treating hypertension by inhibiting vascular structural remodeling [18].…”

Section: Discussionmentioning

confidence: 99%

“…Omentin inhibited platelet-derived growth factor BB-induced vascular smooth muscle cell migration by reducing oxidative stress [18]. This indicates that omentin-1 may serve as a target for treating hypertension by inhibiting vascular structural remodeling [18]. In addition, omentin treatment inhibited pulmonary arterial hypertension in rats by inhibiting vascular structural remodeling and abnormal contractile reactivity [6].…”

Section: Discussionmentioning

confidence: 99%

Association of Serum Omentin-1 Concentrations with the Presence of Atrial Fibrillation

et al. 2016

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BackgroundOmentin-1 is one of the adipokines associated with obesity, diabetes, and coronary heart disease development. We determined to investigate whether serum omentin-1 concentrations were correlated with the presence of atrial fibrillation (AF).Material/MethodsSerum omentin-1 concentrations were examined in a cross-sectional population that included 220 patients with AF (70 with paroxysmal AF, 78 with persistent AF, and 72 with permanent AF) and 115 healthy controls.ResultsReduced serum omentin-1 concentrations were found in AF patients compared to the controls. In addition, patients with permanent AF had lower serum omentin-1 concentrations compared to patients with persistent AF and patients with paroxysmal AF. Significantly decreased serum omentin-1 concentrations were observed in persistent AF patients compared to paroxysmal AF patients. Spearman correlation analysis suggested that serum omentin-1 concentrations were negatively correlated with left atrial diameter in AF patients.ConclusionsSerum omentin-1 concentrations were correlated with the presence of AF and atrial remolding.

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A novel adipocytokine, omentin, inhibits platelet-derived growth factor-BB-induced vascular smooth muscle cell migration through antioxidative mechanism

Abstract: Kazama K, Okada M, Yamawaki H. A novel adipocytokine, omentin, inhibits platelet-derived growth factor-BB-induced vascular smooth muscle cell migration through antioxidative mechanism.

Cited by 44 publications

References 25 publications

Adipocytokines in Cardiovascular and Metabolic Diseases

Adipocytokines in Cardiovascular and Metabolic Diseases

Serum omentin levels: A possible contribution to vascular involvement in patients with systemic sclerosis

Association of Serum Omentin-1 Concentrations with the Presence of Atrial Fibrillation

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