A novel alternative strategy for monitoring and insight into liver fibrosis progression: The combination of surface-enhanced Raman spectroscopy (SERS) and gut microbiota

3D-Printed SERS Chips for Highly Specific Detection of Denatured Type I and IV Collagens in Blood for Early Hepatic Fibrosis Diagnosis

“…SERS is a highly promising technique in biomedical sample detection, showcases exceptional sensitivity, molecular signal specificity, and multiplexing capability, facilitating the simultaneous detection of various biomarkers. , SERS probes exhibit greater stability and ease of storage and labeling compared to fluorescent compounds . SERS chips offer high sensitivity and specificity, making them valuable tools for detecting and analyzing trace amounts of substances. − Individual barcodes based on SERS spectra have been developed for the simultaneous detection of various protein biomarkers . Nevertheless, the intricate, costly, or time-consuming nature of these processes hampers the practical and cost-effective production of SERS chips. − …”