A novel and unusual utility of the cardiosintol drug as a fluoro-prober in the amendment of a highly fluorescent module for determining the non-fluorescent N-acetylcysteine drug

Hamad, Ahmed Abdulhafez; Derayea, Sayed M.

doi:10.1016/j.saa.2023.122460

Cited by 10 publications

(3 citation statements)

References 64 publications

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“…Because the water was used to create the reference material as well as a reaction medium for the system's product, RI = RI f . It is recommended that prepared solutions maintain their absorbance measurements below 0.1 to avoid excessive reabsorption, as suggested by previous studies [63, 64]. It was discovered that the watery dye matrix's quantum efficiency was multiplied many times as the dye and medication complexed.…”

Section: Resultsmentioning

confidence: 99%

Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing

Alqarni,

Haredy,

Abdelrahman

et al. 2024

Luminescence

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The suggested study adheres to a particular protocol to ensure that the process is environmentally friendly and sustainable. It is worth mentioning that several tools have been adopted as prospective measures of the method greenness. Fortunately, the established analytical method is identified as white by the white analytical chemistry (WAC) concept, which uses the red/ green/blue color scheme (RGB 12 tool) to combine ecological and functional factors for the first time in studying of the cited drug. Amlodipine (AMD), a cardiovascular treating agent, belongs to the dihydropyridine class of oral calcium channel‐blocking agents. This article presents a novel, simple, green, one‐pot‐processed, fast, and ultrasensitive fluorimetric approach for monitoring and assessment of AMD using molecular‐size‐dependent fluorescence augmentation of the light scattering‐driven signal of eosin, a biological stain at a wavelength of 415 nm. This enhancement was directly proportional to the size of the produced complex. The linearity range was from 30 to 900 ng mL−1, with corresponding sensitivity limits (detection and quantitation levels) of 9.2 and 28 ng mL−1, respectively. The planned approach was also successfully used to track AMD content in bulk, dosage forms, and bio‐fluids (human plasma and urine). The developed method's eco‐friendliness was established by different eco‐rating metric tools.

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Section: Resultsmentioning

confidence: 99%

Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing

Alqarni,

Haredy,

Abdelrahman

et al. 2024

Luminescence

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show abstract

“…Biological and pharmaceutical analysts play a crucial role in protecting the environment and people from hazardous distribution media and organic residue [ 55 , 56 ]. The field of green analytical chemistry is in a state of continuous development and necessitates regular consideration.…”

Section: Resultsmentioning

confidence: 99%

The first facile optical density-dependent approach for the analysis of doxorubicin, an oncogenic agent accompanied with the co-prescribed drug; paclitaxel

Hamad

2023

BMC Chemistry

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Doxorubicin (DRB) is an anthracycline oncogenic drug extracted from cultures of Streptomyces peucetius var. caesius. It is frequently recommended as an anti-neoplastic agent for the treatment of diverse malignancies. It exerts its antineoplastic effect either via inhibiting the enzyme topoisomerase II and/or via intercalation to DNA or reactive oxygen species generation. In the present article, the direct, simple, one-pot, somewhat eco-safe, and non-extractive spectrophotometric system was executed to track doxorubicin, a chemotherapeutic remedy, in the presence of paclitaxel, a naturally occurring Taxan antineoplastic radical, through the greenness rated method. DRB’s optical density was studied in various mediums and solvents to develop the current approach. An acidic ethanolic solution was found to increase the optical density of the sample significantly. At 480 nm., the most remarkable optical density was obtained. Various experimental factors, including intrinsic media, solvent, pH, and stability time, were investigated and controlled. The current approach achieved linearity within the 0.6–40.0 µg mL-1 range, accompanied by a limit of both detection and quantification (LOD and LOQ) of 0.18 and 0.55 µg mL-1, correspondingly. The approach was validated under the ICH guidelines (Quality Guidelines). The system’s greenness and enhancement degree were estimated.

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“…System eco-friendliness assessment An analyst's primary responsibility is to protect nature and humanity from the chemical and pharmaceutical industries' hazardous radicals and organic waste. 41,54 Efforts to improve green chemistry must continue. The analytical eco-scale rank 55 and the Environmental Quality Methods level 56 are two recent concepts.…”

Section: †)mentioning

confidence: 99%

Facile utility of felumin, a biological dye for the first fluorimetric determination of l-tetramisole drug through an “on–off fluorescence” strategy

Hamad

2023

RSC Adv.

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A novel and unusual utility of the cardiosintol drug as a fluoro-prober in the amendment of a highly fluorescent module for determining the non-fluorescent N-acetylcysteine drug

Cited by 10 publications

References 64 publications

Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing

Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing

The first facile optical density-dependent approach for the analysis of doxorubicin, an oncogenic agent accompanied with the co-prescribed drug; paclitaxel

Facile utility of felumin, a biological dye for the first fluorimetric determination of l-tetramisole drug through an “on–off fluorescence” strategy

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