A novel anti-rheumatic drug suppresses tumor necrosis factor-α and augments interleukin-10 in adjuvant arthritic rats

Hisadome, Masao; Fukuda, Tetsuko; Sumichika, Hiroshi; Hanano, Tokushi; Adachi, Keishi

doi:10.1016/s0014-2999(00)00866-9

Cited by 24 publications

(19 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, LPS-induced cytokines production in adjuvant arthritis rats are augmented in comparison with normal rats [12]. In the present study, both daily and single administration of BLF suppressed TNF-α production and increased IL-10 production in the LPS-stimulated adjuvant arthritis rats (Fig.…”

Section: Discussionsupporting

confidence: 55%

Oral Administration of Lactoferrin Inhibits Inflammation and Nociception in Rat Adjuvant-Induced Arthritis

et al. 2004

View full text Add to dashboard Cite

ABSTRACT. Lactoferrin (LF) is a ubiquitous protein which exists in milk, plasma, synovial fluids, cerebrospinal fluid and other biological fluids. LF is also well known as a natural immunomodulator. Recently, we found that bovine milk-derived LF (BLF) produced µ-opioid receptor-mediated analgesia. In this study, we examined whether oral administration of BLF causes anti-nociceptive and anti-inf lammatory effects, and also whether it modulates LPS-induced TNF-α and IL-10 production in rat model of rheumatoid arthritis (RA), rat adjuvant arthritis. BLF was administrated once daily, starting 3 hr before (preventive experiment) or 19 days after (therapeutic experiment) adjuvant injection. In both experiments, BLF suppressed the development of arthritis and the hyperalgesia in the adjuvant-injec ted paw. The single-administered BLF produced a dose-dependent analgesia, which was reversed by naloxone, in the adjuvant arthritis rats. Both repeated and single administration of BLF suppressed TNF-α production and increased IL-10 production in the LPS-stimulated adjuvant arthritis rats. These results suggest that orally administered BLF has both preventive and therapeutic effects on the developme nt of adjuvant-induced inflammation and pain. Moreover, the immunomodulatory properties of BLF, such as down-regulation of TNF-α and upregulation of IL-10, could be beneficial in the treatment of RA. Thus, we concluded that LF can be safely used as a natural drug for RA patients suffering from joint pain.

show abstract

Section: Discussionsupporting

confidence: 55%

Oral Administration of Lactoferrin Inhibits Inflammation and Nociception in Rat Adjuvant-Induced Arthritis

et al. 2004

View full text Add to dashboard Cite

show abstract

“…IL-4 and IL-10 (Th2 anti-inflammatory cytokines) have been thought to be upstream regulators that control the progression of RA negatively. IL-4 enhances the synthesis and the production of tissue inhibitors of MMPs in human mononuclear phagocytes and cartilage explants, and hence suppresses MMPs activation, while IL-10 inhibits the cytokine production and release by activated macrophages [34,35]. In the present study, all changes in pro-inflammatory and anti-inflammatory cytokines of arthritic rats were completely prevented in arthritic rats that received TRPS only (Fig.…”

Section: Discussionsupporting

confidence: 53%

Anti-inflammatory and Anti-oxidant Properties of Curcuma longa (Turmeric) Versus Zingiber officinale (Ginger) Rhizomes in Rat Adjuvant-Induced Arthritis

2010

View full text Add to dashboard Cite

Turmeric (rich in curcuminoids) and ginger (rich in gingerols and shogaols) rhizomes have been widely used as dietary spices and to treat different diseases in Ayurveda/Chinese medicine since antiquity. Here, we compared the anti-inflammatory/anti-oxidant activity of these two plants in rat adjuvant-induced arthritis (AIA). Both plants (at dose 200 mg/kg body weight) significantly suppressed (but with different degrees) the incidence and severity of arthritis by increasing/decreasing the production of anti-inflammatory/pro-inflammatory cytokines, respectively, and activating the anti-oxidant defence system. The anti-arthritic activity of turmeric exceeded that of ginger and indomethacin (a non-steroidal anti-inflammatory drug), especially when the treatment started from the day of arthritis induction. The percentage of disease recovery was 4.6-8.3% and 10.2% more in turmeric compared with ginger and indomethacin (P < 0.05), respectively. The present study proves the anti-inflammatory/anti-oxidant activity of turmeric over ginger and indomethacin, which may have beneficial effects against rheumatoid arthritis onset/progression as shown in AIA rat model.

show abstract

“…For instance, a novel recent study by Haskó et al (23) reported a potential role for extracellular purines, including adenosine and ATP, and inosine, a degradation product of these purines, as potent endogenous immunomodulatory molecules that inhibit inflammatory cytokine biosynthesis and protect against endotoxin-induced shock. It has also been reported, in addition, that selective inhibition of phosphodiesterases, a family of enzymes involved in the degradation of cAMP (24,25), steroids, such as glucocorticoids (26), pyrimidylpiperazine derivatives (19,(27)(28)(29), and ERK and p38/RK MAPK selective inhibitors (30,31) differentially regulate the transcription and biosynthesis of inflammatory cytokines. The promoters of genes encoding cytokines contain multiple cis-acting motifs including those that bind such transcription factors as NF-B.…”

Section: Vol 285 No 2 2001mentioning

confidence: 99%

Nuclear Factor-κB Blockade Attenuates but Does Not Abrogate Lipopolysaccharide-Dependent Tumor Necrosis Factor-α Biosynthesis in Alveolar Epithelial Cells

Haddad

Land

2001

Biochemical and Biophysical Research Communications

View full text Add to dashboard Cite

A novel anti-rheumatic drug suppresses tumor necrosis factor-α and augments interleukin-10 in adjuvant arthritic rats

Cited by 24 publications

References 14 publications

Oral Administration of Lactoferrin Inhibits Inflammation and Nociception in Rat Adjuvant-Induced Arthritis

Oral Administration of Lactoferrin Inhibits Inflammation and Nociception in Rat Adjuvant-Induced Arthritis

Anti-inflammatory and Anti-oxidant Properties of Curcuma longa (Turmeric) Versus Zingiber officinale (Ginger) Rhizomes in Rat Adjuvant-Induced Arthritis

Nuclear Factor-κB Blockade Attenuates but Does Not Abrogate Lipopolysaccharide-Dependent Tumor Necrosis Factor-α Biosynthesis in Alveolar Epithelial Cells

Contact Info

Product

Resources

About