A Novel Antibacterial Modification Treatment of Titanium Capable to Improve Osseointegration

Valle, Cinzia Della; Visai, Livia; Santin, Matteo; Cigada, A.; Candiani, Gabriele; Pezzoli, Daniele; Arciola, Carla Renata; Imbriani, Marcello; Chiesa, Roberto

doi:10.5301/ijao.5000161

Cited by 48 publications

(37 citation statements)

References 32 publications

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“…Moreover, in vitro and in vivo experiments have shown long-lasting antibacterial protective effects of nanostructured titanium coating incorporated with silver NPs [84,241]. Intense research is being done to combine both the antibacterial effect of silver NP with osteointegrative properties and improved biocompatibility of materials such as titanium alloys [87,187,242,243,244]. Lastly, nanoparticles of selenium, copper, zinc, and other elements have also demonstrated strong antibacterial efficacy [245,246,247].…”

Section: Basic Concepts Of Antibacterial Coatingmentioning

confidence: 99%

Antibacterial Surface Treatment for Orthopaedic Implants

Gallo

Holinka

Moucha

2014

IJMS

295

203

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It is expected that the projected increased usage of implantable devices in medicine will result in a natural rise in the number of infections related to these cases. Some patients are unable to autonomously prevent formation of biofilm on implant surfaces. Suppression of the local peri-implant immune response is an important contributory factor. Substantial avascular scar tissue encountered during revision joint replacement surgery places these cases at an especially high risk of periprosthetic joint infection. A critical pathogenic event in the process of biofilm formation is bacterial adhesion. Prevention of biomaterial-associated infections should be concurrently focused on at least two targets: inhibition of biofilm formation and minimizing local immune response suppression. Current knowledge of antimicrobial surface treatments suitable for prevention of prosthetic joint infection is reviewed. Several surface treatment modalities have been proposed. Minimizing bacterial adhesion, biofilm formation inhibition, and bactericidal approaches are discussed. The ultimate anti-infective surface should be “smart” and responsive to even the lowest bacterial load. While research in this field is promising, there appears to be a great discrepancy between proposed and clinically implemented strategies, and there is urgent need for translational science focusing on this topic.

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Section: Basic Concepts Of Antibacterial Coatingmentioning

confidence: 99%

Antibacterial Surface Treatment for Orthopaedic Implants

Gallo

Holinka

Moucha

2014

IJMS

295

203

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“…Therefore, these are potentially very attractive for surface protection of orthopaedic implants since PJI is biofilm driven in the majority of clinical cases. As a result, silver is the most prevalent metal used in biomedical applications for antibacterial coating of prosthetic metal implants [180,181,182,183,184,185,186,187,188,189,190]. Both uncoated and coated AgNPs on various surfaces, such as titanium surfaces or catheter surfaces, thoroughly inhibit both planktonic and biofilm-forming bacteria [94,167,191,192].…”

Section: Why Silver Nanoparticle Technologies On the Implant Surfamentioning

confidence: 99%

Silver Nanocoating Technology in the Prevention of Prosthetic Joint Infection

et al. 2016

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Prosthetic joint infection (PJI) is a feared complication of total joint arthroplasty associated with increased morbidity and mortality. There is a growing body of evidence that bacterial colonization and biofilm formation are critical pathogenic events in PJI. Thus, the choice of biomaterials for implanted prostheses and their surface modifications may significantly influence the development of PJI. Currently, silver nanoparticle (AgNP) technology is receiving much interest in the field of orthopaedics for its antimicrobial properties and a strong anti-biofilm potential. The great advantage of AgNP surface modification is a minimal release of active substances into the surrounding tissue and a long period of effectiveness. As a result, a controlled release of AgNPs could ensure antibacterial protection throughout the life of the implant. Moreover, the antibacterial effect of AgNPs may be strengthened in combination with conventional antibiotics and other antimicrobial agents. Here, our main attention is devoted to general guidelines for the design of antibacterial biomaterials protected by AgNPs, its benefits, side effects and future perspectives in PJI prevention.

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“…This allows the different chemical elements such as calcium (Ca), phosphorous (P), silicon (Si) and silver (Ag) to be incorporated onto the surface. These novel surfaces can improve the biological response by promoting increased bone-implant contact, improving the osseointegration and the bioactivity of the surface [10-12], and providing antibacterial function [13]. The pore size and the coating type formed on the material may vary with the electrolyte solution, the time of surface treatment employed and with the system voltage and frequency [7].…”

Section: Introductionmentioning

confidence: 99%

“…Some in vitro [13] and in vivo [18] studies have been performed to evaluate PEO coatings. The results showed improved bone healing during osseointegration process and the bioactivity of Ti [8, 13, 18].…”

Section: Introductionmentioning

confidence: 99%

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Electrochemical behavior of bioactive coatings on cp-Ti surface for dental application

et al. 2015

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The surface characteristics and electrochemical properties of bioactive coatings produced by plasma electrolytic oxidation (PEO) with calcium, phosphorous, silicon and silver on commercially pure titanium were evaluated. PEO treatment produced a porous oxide layer, which improved the surface topography, and enriched the surface chemistry with bioactive elements, responsible for mimicking bone surface. The surfaces with higher calcium concentration presented antibacterial and biocompability properties with better responses for corrosion and barrier properties, due to the presence of rutile crystalline structure. PEO may be a promising surface treatment option to improve the electrochemical behavior of dental implants mitigating treatment failures.

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A Novel Antibacterial Modification Treatment of Titanium Capable to Improve Osseointegration

Abstract: Based on the results of this study, we believe that this novel biomimetic and antibacterial treatment hold promise for enhancing osteointegration while conferring strong antibacterial properties to titanium.

Cited by 48 publications

References 32 publications

Antibacterial Surface Treatment for Orthopaedic Implants

Antibacterial Surface Treatment for Orthopaedic Implants

Silver Nanocoating Technology in the Prevention of Prosthetic Joint Infection

Electrochemical behavior of bioactive coatings on cp-Ti surface for dental application

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