A novel antioxidant flavonoid (IdB 1031) affecting molecular mechanisms of cellular activation

Ursini, Fulvio; Maiorino, Matilde; Morazzoni, Paolo; Roveri, Antonella; Pifferi, G.

doi:10.1016/0891-5849(94)90054-x

Cited by 147 publications

(81 citation statements)

References 31 publications

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“…Flavonoids have the potential to bind to the ATP-binding sites of a large number of proteins [38] including, mitochondrial ATPase [50], calcium plasma membrane ATPase [13], protein kinase A [136], protein kinase C [61,81,101,142,176] and topoisomerase [18]. In addition, interactions with the benzodiazepine binding sites of GABA-A receptors and with adenosine receptors [48,117] have been reported.…”

Section: Flavonoid Interactions With Neuronal Signalling Cascadesmentioning

confidence: 99%

The interactions of flavonoids within neuronal signalling pathways

2007

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Emerging evidence suggests that dietary phytochemicals, in particular flavonoids, may exert beneficial effects in the central nervous system by protecting neurons against stress-induced injury, by suppressing neuroinflammation and by promoting neurocognitive performance, through changes in synaptic plasticity. It is likely that flavonoids exert such effects in neurons, through selective actions on different components within a number of protein kinase and lipid kinase signalling cascades, such as phosphatidylinositol-3 kinase (PI3K)/Akt, protein kinase C and mitogen-activated protein kinase. This review details the potential inhibitory or stimulatory actions of flavonoids within these pathways, and describes how such interactions are likely to affect cellular function through changes in the activation state of target molecules and/or by modulating gene expression. Although, precise sites of action are presently unknown, their abilities to: (1) bind to ATP binding sites on enzymes and receptors; (2) modulate the activity of kinases directly; (3) affect the function of important phosphatases; (4) preserve neuronal Ca 2+ homeostasis; and (5) modulate signalling cascades lying downstream of kinases, are explored. Future research directions are outlined in relation to their precise site(s) of action within the signalling pathways and the sequence of events that allow them to regulate neuronal function in the central nervous system.

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Section: Flavonoid Interactions With Neuronal Signalling Cascadesmentioning

confidence: 99%

The interactions of flavonoids within neuronal signalling pathways

2007

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“…There are also other ways how polyphenols can chemically intervene into oxidative processes as shown in experiments in vitro: polyphenols can chelate transition metals like copper and iron, which catalyze propagation of radical chain reactions (Afanas'ev et al 1995;Korkina and Afanas'ev 1997;Brown et al 1998) and inhibit the enzymes responsible for superoxide anion production, such as xanthine oxidase (Arimboor et al 2011) and protein kinase C (Ursini et al 1994). However, interaction of flavonoids with isolated beef heart mitochondria in vitro caused an additional production of ROS due to inhibition of respiratory complex I (Hodnick et al 1986;Hodnick et al 1988;Hodnick, Duval, and Pardini 1994).…”

Section: Polyphenolic Compoundsmentioning

confidence: 99%

Mitochondria and Antioxidants: The Active Players in Islet Oxidative Stress

Votyakova¹,

Bottino²,

Trucco³

2012

Chemical Biology

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“…Flavonoids inhibit the enzymes responsible for superoxide anion production, such as xanthine oxidase [54] and Protein kinase C (PKC) [140], and 2. Flavonoids have also shown to inhibit cyclo-oxygenase, lipoxygenase, microsomal mono-oxygenase, glutathione S-transferase, mitochondrial succinoxidase, and (Nicotinamide adenine denucleotide (NADH) oxidase, all of which are involved in ROS generation [68,15].…”

Section: Scavenging Ros Andmentioning

confidence: 99%

The Role of Natural Antioxidants in Cancer Disease

Moreno¹

2013

Oxidative Stress and Chronic Degenerative Diseases - A Role for Antioxidants

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A novel antioxidant flavonoid (IdB 1031) affecting molecular mechanisms of cellular activation

Cited by 147 publications

References 31 publications

The interactions of flavonoids within neuronal signalling pathways

The interactions of flavonoids within neuronal signalling pathways

Mitochondria and Antioxidants: The Active Players in Islet Oxidative Stress

The Role of Natural Antioxidants in Cancer Disease

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