A novel antioxidant phenanthrenoid dimer from<i>Juncus acutus</i>L.

Behery, Fathy A.; Naeem, Zain-Elabdin M.; Maatooq, Galal T.; Amer, Mohamed; Ahmed, Atallah F.

doi:10.1080/14786419.2012.662759

Cited by 27 publications

(31 citation statements)

References 15 publications

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“…27 According to the immunoblot analysis, the effect of dehydrojuncusol on the iNOS protein (41.0% inhibition at 10 μM) decreased dramatically after dimerization (< 12.0% inhibition at 10 μM).…”

Section: Anti-algal Activitymentioning

confidence: 99%

“…Phenanthrenes isolated from different Juncaceae species exert many different activities, including antitumor, [28][29][30][31][32] anti-inflammatory, 23,27,29,31 antioxidant, 23 anxiolytic, 7,9 cell-protective, 11 sedative, 8,9 and spasmolytic 32 effects.…”

Section: Pharmacology Of Juncaceae Phenanthrenesmentioning

confidence: 99%

“…Therefore, vinylated phenanthrenes can be considered as chemotaxonomic markers of Juncaceae species. [22][23][24][25][26][27][28][29][30][31] Most of the Juncaceae phenanthrenes are substituted with methyl groups. Methyl substitutions were generally found at C-1 or C-7.…”

Section: Chemical Characteristics Of Mono-and Diphenanthrenesmentioning

confidence: 99%

“…antitumor, antibacterial, anti-inflammatory, antioxidant, anxiolytic, cell-protective, sedative, and spasmolytic activities) and their broad structural diversity. [7][8][9]11,23,[27][28][29][30][31][32][33][34][35] Probably, the most investigated naturally occurring phenanthrene derivate is denbinobin, which displays remarkable antitumour activity against several cancer cell lines. Moreover, its anti-HIV property is also very promising.…”

Section: Introductionmentioning

confidence: 99%

“…22 To date, almost one hundred novel phenanthrenes have been isolated from the family, but only from Juncus species. [23][24][25][26][27][28][29][30][31] Although many phenanthrenecontaining species have been used in folk medicine for hundreds of years in order to treat several diseases, however the chemical composition and the mechanism of action of many of these plants have not been studied thoroughly yet. Therefore, these plants and their secondary metabolites are worthy of future investigations.…”

Section: Introductionmentioning

confidence: 99%

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Bioactive secondary metabolites from Juncaceae species

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Section: Anti-algal Activitymentioning

confidence: 99%

Section: Pharmacology Of Juncaceae Phenanthrenesmentioning

confidence: 99%

Section: Chemical Characteristics Of Mono-and Diphenanthrenesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bioactive secondary metabolites from Juncaceae species

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Known or Never before Identified Phenanthrenes: Where It Is Possible to Isolate Them and Why

Fabio

Zarrelli

2022

Chemistry & Biodiversity

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The secondary metabolites of plant origin belong to different and numerous classes of organic compounds. One of these is that of dimeric phenanthrenes, symmetrical or not, characterized by a series of interesting biological activities. Of these compounds, 37 have been isolated since 1988, from only five plant families. Considering each dimer comprises two phenanthrenes and starting from the hypothesis that each dimer is obtained through a biosynthetic mechanism that involves the coupling of the corresponding radicals of the individual phenanthrene units, it is possible to identify 29 phenanthrenes, of which 6 not yet isolated. It is possible to establish that 16 known phenanthrenes can be isolated from 14 different plant species, just as 6 new phenanthrenes can be isolated from 6 different plant species. This would allow a targeted analysis of a few natural extracts from specific plant sources to identify known or new molecules, with potential and/or specific biological activities.

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Chemical Ecology of Marine Angiosperms: Opportunities at the Interface of Marine and Terrestrial Systems

Sieg

Kubanek

2013

J Chem Ecol

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This review examines the state of the field for chemically mediated interactions involving marine angiosperms (seagrasses, mangroves, and salt marsh angiosperms). Small-scale interactions among these plants and their herbivores, pathogens, fouling organisms, and competitors are explored, as are community-level effects of plant secondary metabolites. At larger spatial scales, secondary metabolites from marine angiosperms function as reliable cues for larval settlement, molting, or habitat selection by fish and invertebrates, and can influence community structure and ecosystem function. Several recent studies illustrate the importance of chemical defenses from these plants that deter feeding by herbivores and infection by pathogens, but the extent to which allelopathic compounds kill or inhibit the growth of competitors is less clear. While some phenolic compounds such as ferulic acid and caffeic acid act as critical defenses against herbivores and pathogens, we find that a high total concentration of phenolic compounds within bulk plant tissues is not a strong predictor of defense. Residual chemical defenses prevent shredding or degradation of plant detritus by detritivores and microbes, delaying the time before plant matter can enter the microbial loop. Mangroves, marsh plants, and seagrasses remain plentiful sources of new natural products, but ecological functions are known for only a small proportion of these compounds. As new analytical techniques are incorporated into ecological studies, opportunities are emerging for chemical ecologists to test how subtle environmental cues affect the production and release of marine angiosperm chemical defenses or signaling molecules. Throughout this review, we point to areas for future study, highlighting opportunities for new directions in chemical ecology that will advance our understanding of ecological interactions in these valuable ecosystems.

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A novel antioxidant phenanthrenoid dimer fromJuncus acutusL.

Cited by 27 publications

References 15 publications

Bioactive secondary metabolites from Juncaceae species

Bioactive secondary metabolites from Juncaceae species

Known or Never before Identified Phenanthrenes: Where It Is Possible to Isolate Them and Why

Chemical Ecology of Marine Angiosperms: Opportunities at the Interface of Marine and Terrestrial Systems

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