A novel approach for blood purification: Mixed-matrix membranes combining diffusion and adsorption in one step

Tijink, M.S.L.; Wester, Maarten; Sun, Jiatong; Saris, Anno; Bolhuis-Versteeg, Lydia A.M.; Saiful, Saiful; Joles, Jaap A.; Borneman, Zandrie; Weßling, Matthias; Stamatialis, Dimitrios

doi:10.1016/j.actbio.2012.03.008

Cited by 117 publications

(85 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, Ronco [4] asked the membrane manufacturers to consider the possibility of mixing the biomaterial of a specific membrane with a sorbent material based on a significant enhancement of internal filtration and backfiltration in hollow-fiber hemodialyzers. Recently, some of the authors of this editorial proposed a combination of diffusion and adsorption in one membrane, the so-called mixed matrix membrane (MMM), for removal of uremic solutes [7,8,9]. The MMM concept had been proposed earlier as an alternative to traditional chromatographic columns [10].…”

Section: Figmentioning

confidence: 99%

See 1 more Smart Citation

Mixed Matrix Membranes: A New Asset for Blood Purification Therapies

Tijink¹,

Kooman

Wester

et al. 2014

Blood Purif

View full text Add to dashboard Cite

Section: Figmentioning

confidence: 99%

“…Mixed matrix flat-sheet and hollow-fiber membranes have been developed via phase inversion (fig. 1b, c, 2) [7,8,9]. For the macroporous matrix, cellulose acetate [7] or a polyethersulfone (PES)/polyvinylpyrrolidone (PVP) polymer blend (PES as a membrane-forming polymer blended with PVP to improve hydrophilicity) [8,9] were used.…”

Section: Figmentioning

confidence: 99%

Mixed Matrix Membranes: A New Asset for Blood Purification Therapies

Tijink¹,

Kooman

Wester

et al. 2014

Blood Purif

View full text Add to dashboard Cite

“…Very recently, new approaches for the evolution on the dialysis membrane have been proposed [32]. A combination of the strengths of dialysis membranes and the adsorption power of high-surface-area sorbents can be very beneficial for the efficacy of blood purification.…”

Section: Beyond Diffusion and Convection: Adsorptionmentioning

confidence: 99%

“…A combination of the strengths of dialysis membranes and the adsorption power of high-surface-area sorbents can be very beneficial for the efficacy of blood purification. This is a novel membrane concept combining diffusion and adsorption of uremic retention solutes in one step: the so-called mixed-matrix membrane [32]. In this concept, adsorptive particles are incorporated in a macroporous membrane matrix.…”

Section: Beyond Diffusion and Convection: Adsorptionmentioning

confidence: 99%

Adsorption Dialysis: From Physical Principles to Clinical Applications

Aucella

Gesuete

Vigilante³

et al. 2013

Blood Purif

View full text Add to dashboard Cite

The uremic syndrome is characterized by the retention of various solutes that would normally be excreted by the kidneys. The substances that interact negatively with biologic functions are called uremic toxins. Over the past five decades, the membranes used for the treatment of chronic kidney disease have continuously evolved. The exposure of blood to any extracorporeal artificial surface results in the activation of several pathways within the body, including those involving coagulation and complement activation. One of the by-products of this generalized activation process is protein adsorption to the membrane surface, another phenomenon which can have a significant impact on solute removal. In fact, an array of studies showed that with increasing size of middle-sized proteins and other compounds, relatively more clearance is achieved by membrane adsorption compared with loss into the dialysate. A high adsorptive capacity, one of the main features of polymethylmethacrylate (PMMA) membranes, is very helpful and may both increase the total amount of solutes removed and remove different kinds of solutes. In this setting, a few studies have shown a variety of efficient clinical implications for adsorption hemodialysis, such as uremic pruritus, anemia, carpal tunnel syndrome and renal amyloidosis, immune dysfunction and improved response to vaccination. In addition, nutrition and survival were also improved using PMMA membranes.

show abstract

“…Protein-bound toxins can also be targeted via adsorption. For example, multilayered mixed matrix membranes (MMM) using activated carbon for the removal of protein-bound toxins have been developed in the recent years [45][46][47][48].…”

Section: Chaptermentioning

confidence: 99%

Development of an upscaled bioartificial kidney

Chevtchik¹

View full text Add to dashboard Cite

Printed by Gildeprint, Enschede, the Netherlands, Cover design by Natalia Chevtchik and Felix Broens Front page: confocal microscopy image of conditionnaly imrtalized proximal tubule renal epithelial cells (ciPTEC) cultured on polymeric hollow fiber membranes (HFM) with DAPI staining of the nuclei and immunostaining for the tight junction protein ZO-1. The kidneys are composed of hundreds of thousands of filtration units called nephrons (see Figure 1). In the nephron, blood initially passes through the glomerulus where small and middle-size solutes and excess fluids are removed out of the blood by convection. This glomerular filtrate is then transferred to the proximal tubules, which are responsible for reabsorbing essential components of the pre-urine but also for additional removal of a great variety of solutes and wastes from the blood stream, among which, the protein-bound toxins. More details about kidney physiology are explained in chapter 2 of this thesis. DEVELOPMENT OF AN UPSCALED BIOARTIFICIAL KIDNEY Kidney diseaseMore than 10% of the worldwide population is estimated to present a more or less severe form of kidney disease [4][5][6] Chapter 1 4 Renal replacement therapiesThe most common treatment for CKD, ESRD and AKI patients is artificial kidney or dialysis, applied for 2.2 million patients worldwide [10]. This treatment only covers a fraction of the physiological renal function -mostly that of the glomerulus in the normal kidney -and its efficiency in waste removal is incomplete [11, 12]. Indeed, only small water-soluble molecules, inferior to 40 kDa, present in free fraction in the blood, can be eliminated [13] whereas most of the big size and protein bound toxins cannot be removed. Their accumulation is strongly linked to the fatal outcome of the hemodialysed population [14][15][16].These toxins are in large part handled by the proximal tubules in the healthy kidneys [13, 17]. Besides, dialysis is removing a part of the toxin population but is not replacing the kidney endocrine and metabolic physiological functions. The need for a more complete renal replacement therapyThere is a strong need for a device, extracorporeal or implantable, which could fully replace the kidney function. Such a device could be a hybrid combination of polymeric membranes and renal proximal tubule epithelial cells (PTEC), called the bioartificial kidney (BAK). The BAK is conceived to be used in combination with a classical hemofilter [18, 19]. In this way, there is a direct similitude with the natural kidney. First, the glomerular function is replaced by the classical hemodialysis for removal of small size water-soluble molecules.Second, the glomerular filtrate, which comes out of the hemodialysis module, can be processed by the PTEC of the BAK. The principle of application of the BAK is presented in Figure 2.The first BAK prototype was presented by Aebisher et al. in 1987 [21]. Since then, several other prototypes have been proposed by the groups of Humes, Zink and Saito [18,[22][23][24][25][26][27][28][29]. The first...

show abstract

A novel approach for blood purification: Mixed-matrix membranes combining diffusion and adsorption in one step

Cited by 117 publications

References 39 publications

Mixed Matrix Membranes: A New Asset for Blood Purification Therapies

Mixed Matrix Membranes: A New Asset for Blood Purification Therapies

Adsorption Dialysis: From Physical Principles to Clinical Applications

Development of an upscaled bioartificial kidney

Contact Info

Product

Resources

About