A Novel Approach for Transferring Oleic Acid Capped Iron Oxide Nanoparticles to Water Phase

Wang, Miao; Peng, Mingli; Cheng, Wu-Long; Cui, Yali; Chen, Chao

doi:10.1166/jnn.2011.3751

Cited by 37 publications

(18 citation statements)

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“…As illustrated in Figure 2, hydrophobic oleic acid capped Fe 3 O 4 nanoseeds were first treated with NaIO 4 to make their surface hydrophilic. [17] The strong oxidizer-NaIO 4 breaks the double bond in oleic acid and generates a carboxyl group at the end of the ligand (zeta potential: -23.5 mV). The precursor of the upconversion nanophosphor (Gd 2 O(CO 3 ) 2 •H 2 O:Yb/Er or Yb/Tm) was deposited on the surface of iron oxide nanoparticles sequentially by a modified protocol from literature.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Brightly PEGylated Luminescent Magnetic Upconversion Nanophosphors for Deep Tissue and Dual MRI Imaging

Chen

Moore

et al. 2013

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We developed a novel method to fabricate monodispersed biocompatible Yb/Er or Yb/Tm doped β-NaGdF4 upconversion phosphors using polyelectrolytes to prevent irreversible particle aggregation during the conversion of the precursor (Gd2O(CO3)2•H2O:Yb/Er or Yb/Tm) to β-NaGdF4:Yb/Er or Yb/Tm. The polyelectrolyte on the outer surface of nanophosphors also provided an amine tag for PEGylation. This method is also employed to fabricate PEGylated magnetic upconversion phosphors with Fe3O4 as the core and β-NaGdF4 as a shell. These magnetic upconversion nanophosphors have relatively high saturation magnetization (7.0 emu g-1) and magnetic susceptibility (1.7×10-2 emu g-1 Oe-1), providing them with large magnetophoretic mobilities. We have studied their magnetic properties for separation and controlled release in flow, their optical properties for cell labeling, deep tissue imaging, and their T1 and T2-weighted magnetic resonance imaging (MRI) relaxivities. The magnetic upconversion phosphors display both strong magnetophoresis, dual MRI imaging (r1=2.9 mM-1 s-1, r2=204 mM-1 s-1), and bright luminescence under 1 cm chicken breast.

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Section: Resultsmentioning

confidence: 99%

Synthesis of Brightly PEGylated Luminescent Magnetic Upconversion Nanophosphors for Deep Tissue and Dual MRI Imaging

Chen

Moore

et al. 2013

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“…The transfer of Fe3O4 NPs from hexane to water was through a simple method, which is by oxidation of oleic acid [ 20,21]. Firstly, the mixture of ethyl acetate and acetonitrile at 1:1 volume ratio was added into the hexane containing as-synthesized Fe3O4 NPs (10 mg).…”

Section: Transfer Of Fe3o4 Nps Into Watermentioning

confidence: 99%

Human-like collagen protein-coated magnetic nanoparticles with high magnetic hyperthermia performance and improved biocompatibility

Liu¹,

Zhang²,

Chang³

et al. 2016

Nano Online

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Human-like collagen (HLC)-coated monodispersed superparamagnetic Fe3O4 nanoparticles have been successfully prepared to investigate its effect on heat induction property and cell toxicity. After coating of HLC, the sample shows a faster rate of temperature increase under an alternating magnetic field although it has a reduced saturation magnetization. This is most probably a result of the effective heat conduction and good colloid stability due to the high charge of HLC on the surface. In addition, compared with Fe3O4 nanoparticles before coating with HLC, HLC-coated Fe3O4 nanoparticles do not induce notable cytotoxic effect at higher concentration which indicates that HLC-coated Fe3O4 nanoparticles has improved biocompatibility. Our results clearly show that Fe 3O4 nanoparticles after coating with HLC not only possess effective heat induction for cancer treatment but also have improved biocompatibility for biomedicine applications.

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“…The transfer of Fe 3 O 4 NPs from hexane to water was through a simple method, which is by oxidation of oleic acid [ 20 , 21 ]. Firstly, the mixture of ethyl acetate and acetonitrile at 1:1 volume ratio was added into the hexane containing as-synthesized Fe 3 O 4 NPs (10 mg).…”

Section: Methodsmentioning

confidence: 99%

Human-like collagen protein-coated magnetic nanoparticles with high magnetic hyperthermia performance and improved biocompatibility

et al. 2015

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Human-like collagen (HLC)-coated monodispersed superparamagnetic Fe3O4 nanoparticles have been successfully prepared to investigate its effect on heat induction property and cell toxicity. After coating of HLC, the sample shows a faster rate of temperature increase under an alternating magnetic field although it has a reduced saturation magnetization. This is most probably a result of the effective heat conduction and good colloid stability due to the high charge of HLC on the surface. In addition, compared with Fe3O4 nanoparticles before coating with HLC, HLC-coated Fe3O4 nanoparticles do not induce notable cytotoxic effect at higher concentration which indicates that HLC-coated Fe3O4 nanoparticles has improved biocompatibility. Our results clearly show that Fe3O4 nanoparticles after coating with HLC not only possess effective heat induction for cancer treatment but also have improved biocompatibility for biomedicine applications.

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A Novel Approach for Transferring Oleic Acid Capped Iron Oxide Nanoparticles to Water Phase

Cited by 37 publications

References 0 publications

Synthesis of Brightly PEGylated Luminescent Magnetic Upconversion Nanophosphors for Deep Tissue and Dual MRI Imaging

Synthesis of Brightly PEGylated Luminescent Magnetic Upconversion Nanophosphors for Deep Tissue and Dual MRI Imaging

Human-like collagen protein-coated magnetic nanoparticles with high magnetic hyperthermia performance and improved biocompatibility

Human-like collagen protein-coated magnetic nanoparticles with high magnetic hyperthermia performance and improved biocompatibility

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